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Tbio
ZFYVE9
Zinc finger FYVE domain-containing protein 9

Protein Summary
Description
Early endosomal protein that functions to recruit SMAD2/SMAD3 to intracellular membranes and to the TGF-beta receptor. Plays a significant role in TGF-mediated signaling by regulating the subcellular location of SMAD2 and SMAD3 and modulating the transcriptional activity of the SMAD3/SMAD4 complex. Possibly associated with TGF-beta receptor internalization. This gene encodes a double zinc finger motif-containing protein that participates in the transforming growth factor-beta (TGFB) signalling pathway. The encoded protein interacts directly with SMAD2 and SMAD3, and recruits SMAD2 to the TGFB receptor. There are multiple pseudogenes for this gene on chromosomes 2, 15, and X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000287727
  • ENSP00000287727
  • ENSG00000157077
  • ENST00000357206
  • ENSP00000349737
  • ENST00000371591
  • ENSP00000360647

Symbol
  • MADHIP
  • SARA
  • SMADIP
  • NSP
  • SARA
  • MADHIP
  • SMADIP
  • PPP1R173
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.92
kinase perturbation
0.84
histone modification site profile
0.71
tissue sample
0.71
small molecule perturbation
0.62


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 155.27   (req: < 5)
Gene RIFs: 16   (req: <= 3)
Antibodies: 84   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 155.27   (req: >= 5)
Gene RIFs: 16   (req: > 3)
Antibodies: 84   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (4)
1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (19)
Disease (R-HSA-1643685)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Disease
Reactome
Diseases of signal transduction
Reactome
Downregulation of TGF-beta receptor signaling
Reactome
Loss of Function of SMAD2/3 in Cancer
Reactome
Loss of Function of TGFBR1 in Cancer
Name
Explore in Pharos
Explore in Source
Disease
Diseases of signal transduction
Downregulation of TGF-beta receptor signaling
Loss of Function of SMAD2/3 in Cancer
Loss of Function of TGFBR1 in Cancer
Protein-Protein Interactions (71)
1 – 10 of 71
PPP1CC
Tchem
Family: Enzyme
Novelty: 0.00465946
p_int: 0.999999998
p_ni: 2e-9
p_wrong: 1e-9
Score: 0.509
Data Source: BioPlex,Reactome,STRINGDB
PPP1CA
Tchem
Family: Enzyme
Novelty: 0.00354658
p_int: 0.999999995
p_ni: 5e-9
Score: 0.931
Data Source: BioPlex,Reactome,STRINGDB
SMAD2
Tbio
Family: TF
Novelty: 0.00040166
p_int: 0.999999952
p_ni: 4.5e-8
p_wrong: 2e-9
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
SMAD3
Tbio
Family: TF
Novelty: 0.00048058
p_int: 0.99999986
p_ni: 9.1e-8
p_wrong: 4.8e-8
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
NCKIPSD
Tbio
Novelty: 0.07453111
p_int: 0.999945448
p_ni: 0.000054544
p_wrong: 8e-9
Score: 0.173
Data Source: BioPlex,STRINGDB
DEFA6
Tbio
Novelty: 0.0363171
p_int: 0.999703496
p_ni: 0.000294478
p_wrong: 0.000002026
Score: 0.188
Data Source: BioPlex,STRINGDB
SMAD7
Tbio
Family: TF
Novelty: 0.00116343
Score: 0.974
Data Source: Reactome,STRINGDB
TGFBR1
Tchem
Family: Kinase
Novelty: 0.00081645
Score: 0.964
Data Source: Reactome,STRINGDB
SMURF2
Tbio
Family: Enzyme
Novelty: 0.00920984
Score: 0.955
Data Source: STRINGDB
PML
Tbio
Novelty: 0.00285474
Score: 0.95
Data Source: STRINGDB
Publication Statistics
PubMed Score  155.27

PubMed score by year
PubTator Score  331.4

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer