Tbio ZFYVE9 Zinc finger FYVE domain-containing protein 9

Protein Summary

Description

Early endosomal protein that functions to recruit SMAD2/SMAD3 to intracellular membranes and to the TGF-beta receptor. Plays a significant role in TGF-mediated signaling by regulating the subcellular location of SMAD2 and SMAD3 and modulating the transcriptional activity of the SMAD3/SMAD4 complex. Possibly associated with TGF-beta receptor internalization. This gene encodes a double zinc finger motif-containing protein that participates in the transforming growth factor-beta (TGFB) signalling pathway. The encoded protein interacts directly with SMAD2 and SMAD3, and recruits SMAD2 to the TGFB receptor. There are multiple pseudogenes for this gene on chromosomes 2, 15, and X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013]

Uniprot Accession IDs

• O95405
• Q5T0F6
• Q5T0F7
• Q9UNE1
• Q9Y5R7

Gene Name

• ZFYVE9

Ensembl ID

• ENST00000287727
• ENSP00000287727
• ENSG00000157077
• ENST00000357206
• ENSP00000349737
• ENST00000371591
• ENSP00000360647

Symbol

• MADHIP
• SARA
• SMADIP
• NSP
• SARA
• MADHIP
• SMADIP
• PPP1R173

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.92
kinase perturbation	0.84
histone modification site profile	0.71
tissue sample	0.71
small molecule perturbation	0.62

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 159.49   (req: < 5)

Gene RIFs: 19   (req: <= 3)

Antibodies: 84   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 159.49   (req: >= 5)

Gene RIFs: 19   (req: > 3)

Antibodies: 84   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0