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Tbio
MED26
Mediator of RNA polymerase II transcription subunit 26

Protein Summary
Description
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors. The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit com ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000263390
  • ENSP00000263390
  • ENSG00000105085
  • ENST00000611692
  • ENSP00000484490

Symbol
  • ARC70
  • CRSP7
  • CRSP7
  • CRSP70
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.92
kinase perturbation
0.81
transcription factor binding site profile
0.77
histone modification site profile
0.73
tissue sample
0.68


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.34   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 264   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.34   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 264   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
2
1
2
60.3
intelligence
1
1
1
17.8
1
1
1
17.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
2
60.3
intelligence
1
17.8
1
17.8
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
mediator complex subunit 26
468762
Mouse
MGI:1917875
70625
Rat
RGD:1309524
306328
Dog
mediator complex subunit 26
484847
Cow
mediator complex subunit 26
506331
Species
Name
OMA
EggNOG
Inparanoid
Chimp
mediator complex subunit 26
Mouse
Rat
Dog
mediator complex subunit 26
Cow
mediator complex subunit 26
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O95402-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (9)
Developmental Biology (R-HSA-1266738)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Developmental Biology
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
Metabolism
Reactome
Metabolism of lipids
Name
Explore in Pharos
Explore in Source
Developmental Biology
Gene expression (Transcription)
Generic Transcription Pathway
Metabolism
Metabolism of lipids
Protein-Protein Interactions (133)
1 – 10 of 133
MED21
Tbio
Family: Enzyme
Novelty: 0.06996616
p_int: 0.999999984
p_ni: 1.5e-8
p_wrong: 1e-9
Score: 0.989
Data Source: BioPlex,STRINGDB
MED19
Tbio
Family: Enzyme
Novelty: 0.03926689
p_int: 0.999999972
p_ni: 2.5e-8
p_wrong: 3e-9
Score: 0.993
Data Source: BioPlex,STRINGDB
MED18
Tbio
Family: Enzyme
Novelty: 0.04066825
p_int: 0.999999958
p_ni: 3.8e-8
p_wrong: 3e-9
Score: 0.999
Data Source: BioPlex,STRINGDB
MED1
Tbio
Family: Enzyme
Novelty: 0.00852082
p_int: 0.999999839
p_ni: 1.6e-7
Score: 0.984
Data Source: BioPlex,STRINGDB
MED28
Tbio
Family: Enzyme
Novelty: 0.00362108
p_int: 0.999999788
p_ni: 2.12e-7
Score: 0.999
Data Source: BioPlex,STRINGDB
MED4
Tbio
Family: Enzyme
Novelty: 0.01200585
p_int: 0.999999715
p_ni: 2.85e-7
Score: 0.972
Data Source: BioPlex,STRINGDB
MED20
Tbio
Family: Enzyme
Novelty: 0.02039559
p_int: 0.999999525
p_ni: 4.75e-7
Score: 0.955
Data Source: BioPlex,STRINGDB
MED10
Tdark
Family: Enzyme
Novelty: 0.02988632
p_int: 0.99999949
p_ni: 5.1e-7
Score: 0.975
Data Source: BioPlex,STRINGDB
MED17
Tbio
Family: Enzyme
Novelty: 0.02984503
p_int: 0.999998604
p_ni: 0.000001396
Score: 0.969
Data Source: BioPlex,STRINGDB
MED7
Tbio
Family: Enzyme
Novelty: 0.04773947
p_int: 0.999986776
p_ni: 0.000013223
p_wrong: 1e-9
Score: 0.996
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  14.34

PubMed score by year
PubTator Score  11.98

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer