You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
CD2BP2
CD2 antigen cytoplasmic tail-binding protein 2

Protein Summary
Description
Involved in pre-mRNA splicing as component of the U5 snRNP complex that is involved in spliceosome assembly. This gene encodes a bi-functional protein. In the cytoplasm, the encoded protein binds the cytoplasmic tail of human surface antigen CD2 via its C-terminal GYF domain, and regulate CD2-triggered T lymphocyte activation. In the nucleus, this protein is a component of the U5 small nuclear ribonucleoprotein complex and is involved in RNA splicing. A pseudogene has been identified on chromosome 7. Alternative splicing results in multiple transcript variants but their biological validity has not been determined. [provided by RefSeq, Nov 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000305596
  • ENSP00000304903
  • ENSG00000169217
  • ENST00000569466
  • ENSP00000456935

Symbol
  • KIAA1178
  • LIN1
  • Snu40
  • FWP010
  • U5-52K
  • PPP1R59
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.87
histone modification site profile
0.86
kinase perturbation
0.71
transcription factor perturbation
0.68
microRNA
0.67


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 69.12   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 174   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 69.12   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 174   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (249)
TSSC4
Tdark
Novelty:  0.17064786
p_int:  0.999998878
p_ni:  0.000001122
Score:  0.839
Data Source:  BioPlex,STRINGDB
ACAD11
Tbio
Family:  Enzyme
Novelty:  0.22908145
p_int:  0.999990047
p_ni:  0.000009953
Score:  0.539
Data Source:  BioPlex,STRINGDB
DDX23
Tbio
Family:  Enzyme
Novelty:  0.03592096
p_int:  0.999988657
p_ni:  0.000011343
Score:  0.995
Data Source:  BioPlex,STRINGDB
SNRNP40
Tbio
Novelty:  0.16791896
p_int:  0.999951946
p_ni:  0.000048054
Score:  0.988
Data Source:  BioPlex,STRINGDB
SNRNP200
Tchem
Family:  Enzyme
Novelty:  0.01339666
p_int:  0.999630238
p_ni:  0.000369762
Score:  0.997
Data Source:  BioPlex,STRINGDB
EAPP
Tbio
Novelty:  0.06519266
p_int:  0.999550561
p_ni:  0.000449439
Score:  0.682
Data Source:  BioPlex,STRINGDB
PRPF8
Tbio
Novelty:  0.01717158
p_int:  0.999515873
p_ni:  0.000484127
Score:  0.996
Data Source:  BioPlex,STRINGDB
PRPF6
Tbio
Novelty:  0.02818008
p_int:  0.999512394
p_ni:  0.000487606
Score:  0.999
Data Source:  BioPlex,STRINGDB
TXNL4A
Tbio
Novelty:  0.04677517
p_int:  0.999159693
p_ni:  0.000840307
Score:  0.999
Data Source:  BioPlex,STRINGDB
EFTUD2
Tbio
Novelty:  0.01805571
p_int:  0.999069373
p_ni:  0.000930627
Score:  0.994
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
Metabolism of RNA (R-HSA-8953854)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of RNA
Reactome
Processing of Capped Intron-Containing Pre-mRNA
Reactome
mRNA Splicing
Reactome
mRNA Splicing - Major Pathway
Name
Explore in Pharos
Explore in Source
Metabolism of RNA
Processing of Capped Intron-Containing Pre-mRNA
mRNA Splicing
mRNA Splicing - Major Pathway
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sodium measurement
2
2
2
56.6
eosinophil count
1
1
1
29
electrocardiography
1
1
2
26.1
eosinophil percentage of leukocytes
1
1
1
8.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sodium measurement
2
56.6
eosinophil count
1
29
electrocardiography
2
26.1
eosinophil percentage of leukocytes
1
8.4
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
CD2 cytoplasmic tail binding protein 2
VGNC:13680
467947
Macaque
CD2 cytoplasmic tail binding protein 2
709961
Mouse
MGI:1917483
70233
Rat
RGD:1311741
293505
Dog
CD2 cytoplasmic tail binding protein 2
VGNC:38946
489937
Species
Name
OMA
EggNOG
Inparanoid
Chimp
CD2 cytoplasmic tail binding protein 2
Macaque
CD2 cytoplasmic tail binding protein 2
Mouse
Rat
Dog
CD2 cytoplasmic tail binding protein 2
Publication Statistics
PubMed Score 69.12
PubMed score by year
PubTator Score 28.12
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title