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Tchem
RAPGEF3
Rap guanine nucleotide exchange factor 3

Protein Summary
Description
Guanine nucleotide exchange factor (GEF) for RAP1A and RAP2A small GTPases that is activated by binding cAMP. Through simultaneous binding of PDE3B to RAPGEF3 and PIK3R6 is assembled in a signaling complex in which it activates the PI3K gamma complex and which is involved in angiogenesis. Plays a role in the modulation of the cAMP-induced dynamic control of endothelial barrier function through a pathway that is independent on Rho-mediated signaling. Required for the actin rearrangement at cell-cell junctions, such as stress fibers and junctional actin.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000389212
  • ENSP00000373864
  • ENSG00000079337
  • ENST00000395358
  • ENSP00000378764
  • ENST00000405493
  • ENSP00000384521
  • ENST00000449771
  • ENSP00000395708
  • ENST00000549151
  • ENSP00000448619

Symbol
  • CGEF1
  • EPAC
  • EPAC1
  • EPAC
  • EPAC1
  • bcm910
  • HSU79275
  • CAMP-GEFI
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
biological process
0.98
biological term
0.89
transcription factor perturbation
0.88
molecular function
0.86


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 544.7   (req: < 5)
Gene RIFs: 131   (req: <= 3)
Antibodies: 224   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 544.7   (req: >= 5)
Gene RIFs: 131   (req: > 3)
Antibodies: 224   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (1)
1 – 1 of 1
ESI-09
chemical structure image
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
5
1
5
84.8
body mass index
1
1
1
51.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
5
84.8
body mass index
1
51.2
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
Rap guanine nucleotide exchange factor 3
VGNC:5565
467198
Macaque
Rap guanine nucleotide exchange factor 3
703967
Mouse
MGI:2441741
223864
Rat
RGD:621869
59326
Dog
Rap guanine nucleotide exchange factor 3
VGNC:45348
486591
Species
Name
OMA
EggNOG
Inparanoid
Chimp
Rap guanine nucleotide exchange factor 3
Macaque
Rap guanine nucleotide exchange factor 3
Mouse
Rat
Dog
Rap guanine nucleotide exchange factor 3
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-O95398-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (34)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 13
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
Reactome
Hemostasis
Reactome
Immune System
Reactome
Integration of energy metabolism
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
Hemostasis
Immune System
Integration of energy metabolism
Protein-Protein Interactions (148)
1 – 10 of 148
RAP1B
Tbio
Family: Enzyme
Novelty: 0.00627538
Score: 0.98
Data Source: Reactome,STRINGDB
RAP1A
Tchem
Family: Enzyme
Novelty: 0.00375413
Score: 0.98
Data Source: Reactome,STRINGDB
ABCC8
Tclin
Family: Transporter
Novelty: 0.00085572
Score: 0.962
Data Source: STRINGDB
ADCY6
Tchem
Family: Enzyme
Novelty: 0.00528765
Score: 0.962
Data Source: STRINGDB
ADCY5
Tchem
Family: Enzyme
Novelty: 0.00307839
Score: 0.96
Data Source: STRINGDB
RAP2B
Tbio
Family: Enzyme
Novelty: 0.00347321
Score: 0.959
Data Source: STRINGDB
ADCY8
Tbio
Family: Enzyme
Novelty: 0.00510386
Score: 0.958
Data Source: STRINGDB
AKAP5
Tbio
Family: Enzyme
Novelty: 0.00351101
Score: 0.953
Data Source: STRINGDB
RAF1
Tclin
Family: Kinase
Novelty: 0.00117121
Score: 0.933
Data Source: STRINGDB
PRKACB
Tchem
Family: Kinase
Novelty: 0.01962222
Score: 0.925
Data Source: STRINGDB
Publication Statistics
PubMed Score  544.70

PubMed score by year
PubTator Score  338.76

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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