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Tbio
WISP1
WNT1-inducible-signaling pathway protein 1

Protein Summary
Description
Downstream regulator in the Wnt/Frizzled-signaling pathway. Associated with cell survival. Attenuates p53-mediated apoptosis in response to DNA damage through activation of AKT kinase. Up-regulates the anti-apoptotic Bcl-X(L) protein. Adheres to skin and melanoma fibroblasts. In vitro binding to skin fibroblasts occurs through the proteoglycans, decorin and biglycan. This gene encodes a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like domain. This gene may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. It is expresse ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000220856
  • ENSP00000220856
  • ENSG00000104415
  • ENST00000250160
  • ENSP00000250160
  • ENST00000517423
  • ENSP00000427744
  • ENST00000519433
  • ENSP00000429185

Symbol
  • CCN4
  • WISP1
  • WISP1c
  • WISP1i
  • WISP1tc
  • WISP1-OT1
  • WISP1-UT1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.97
gene perturbation
0.95
PubMedID
0.77
disease perturbation
0.74
biological term
0.62


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 179.33   (req: < 5)
Gene RIFs: 112   (req: <= 3)
Antibodies: 328   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 179.33   (req: >= 5)
Gene RIFs: 112   (req: > 3)
Antibodies: 328   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0