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Tchem
MAP3K6
Mitogen-activated protein kinase kinase kinase 6

Protein Summary
Description
Component of a protein kinase signal transduction cascade. Activates the JNK, but not ERK or p38 kinase pathways. This gene encodes a serine/threonine protein kinase that forms a component of protein kinase-mediated signal transduction cascades. The encoded kinase participates in the regulation of vascular endothelial growth factor (VEGF) expression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000357582
  • ENSP00000350195
  • ENSG00000142733
  • ENST00000374040
  • ENSP00000363152
  • ENST00000493901
  • ENSP00000419591

Symbol
  • ASK2
  • MAPKKK6
  • MEKK6
  • ASK2
  • MEKK6
  • MAPKKK6
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.98
protein domain
0.92
gene perturbation
0.88
transcription factor binding site profile
0.79
histone modification site profile
0.67


Related Tools
ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.96   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 201   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.96   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 201   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (1)
1 – 1 of 1
CHEMBL1642655
chemical structure image
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
mitogen-activated protein kinase kinase kinase 6
VGNC:8073
456674
Macaque
mitogen-activated protein kinase kinase kinase 6
715911
Mouse
MGI:1855691
53608
Rat
RGD:1304625
313022
Dog
mitogen-activated protein kinase kinase kinase 6
VGNC:42976
487345
Species
Name
OMA
EggNOG
Inparanoid
Chimp
mitogen-activated protein kinase kinase kinase 6
Macaque
mitogen-activated protein kinase kinase kinase 6
Mouse
Rat
Dog
mitogen-activated protein kinase kinase kinase 6
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-O95382-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Protein-Protein Interactions (33)
1 – 10 of 33
TNFSF13B
Tclin
Novelty: 0.00069885
p_int: 0.999999892
p_ni: 1.06e-7
p_wrong: 1e-9
Data Source: BioPlex
PLEKHO2
Tdark
Novelty: 0.48296621
p_int: 0.999999797
p_ni: 2.02e-7
p_wrong: 1e-9
Score: 0.24
Data Source: BioPlex,STRINGDB
HSP90AA5P
Tdark
p_int: 0.999963331
p_ni: 0.000036669
p_wrong: 1e-9
Data Source: BioPlex
HSP90AA4P
Tdark
p_int: 0.999858549
p_ni: 0.000141448
p_wrong: 3e-9
Data Source: BioPlex
FKBP5
Tchem
Family: Enzyme
Novelty: 0.00214511
p_int: 0.999753751
p_ni: 0.000246249
Score: 0.339
Data Source: BioPlex,STRINGDB
HSP90AB4P
Tdark
p_int: 0.998101209
p_ni: 0.001898791
Data Source: BioPlex
USP4
Tbio
Family: Enzyme
Novelty: 0.01101075
p_int: 0.997891198
p_ni: 0.001165749
p_wrong: 0.000943053
Data Source: BioPlex
LIMD1
Tbio
Novelty: 0.04868333
p_int: 0.995447148
p_ni: 0.004552609
p_wrong: 2.43e-7
Data Source: BioPlex
PCDHA4
Tdark
Novelty: 0.30511211
p_int: 0.990374772
p_ni: 0.009625228
Data Source: BioPlex
RNF123
Tbio
Family: Enzyme
Novelty: 0.01872044
p_int: 0.981882436
p_ni: 0.018117564
Score: 0.333
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  26.96

PubMed score by year
PubTator Score  14.6

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer