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Tbio
TNFAIP8
Tumor necrosis factor alpha-induced protein 8

Protein Summary
Description
Acts as a negative mediator of apoptosis and may play a role in tumor progression. Suppresses the TNF-mediated apoptosis by inhibiting caspase-8 activity but not the processing of procaspase-8, subsequently resulting in inhibition of BID cleavage and caspase-3 activation.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000274456
  • ENSP00000274456
  • ENSG00000145779
  • ENST00000503646
  • ENSP00000421848
  • ENST00000504771
  • ENSP00000422245
  • ENST00000513374
  • ENSP00000427424

Symbol
  • NDED
  • GG2-1
  • SCCS2
  • SCC-S2
  • MDC-3.13
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.92
PubMedID
0.91
kinase perturbation
0.88
interacting protein
0.85
transcription factor perturbation
0.8


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 84.24   (req: < 5)
Gene RIFs: 27   (req: <= 3)
Antibodies: 227   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 84.24   (req: >= 5)
Gene RIFs: 27   (req: > 3)
Antibodies: 227   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (24)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
5
14
18
95.1
waist-hip ratio
4
13
15
95.1
hip circumference
1
10
10
92.2
lymphocyte count
2
2
2
92
triglyceride measurement
4
2
4
84.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
18
95.1
waist-hip ratio
15
95.1
hip circumference
10
92.2
lymphocyte count
2
92
triglyceride measurement
4
84.7
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
TNF alpha induced protein 8
VGNC:4205
462017
Macaque
TNF alpha induced protein 8
700778
Mouse
MGI:2147191
106869
Rat
RGD:1305908
307428
Dog
TNF alpha induced protein 8
VGNC:47652
481428
Species
Name
OMA
EggNOG
Inparanoid
Chimp
TNF alpha induced protein 8
Macaque
TNF alpha induced protein 8
Mouse
Rat
Dog
TNF alpha induced protein 8
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-O95379-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (5)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
PI Metabolism
Reactome
Phospholipid metabolism
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of lipids
PI Metabolism
Phospholipid metabolism
Protein-Protein Interactions (22)
1 – 10 of 22
TNF
Tclin
Novelty:  0.00001457
Score:  0.871
Data Source:  STRINGDB
FBXW5
Tbio
Novelty:  0.13100873
Score:  0.735
Data Source:  STRINGDB
LATS1
Tchem
Family:  Kinase
Novelty:  0.00369058
Score:  0.642
Data Source:  STRINGDB
PRR16
Tdark
Novelty:  0.17809341
Score:  0.627
Data Source:  STRINGDB
RIC8A
Tbio
Novelty:  0.01846696
Score:  0.626
Data Source:  STRINGDB
POMP
Tbio
Novelty:  0.01885028
Score:  0.626
Data Source:  STRINGDB
RASA3
Tbio
Family:  Enzyme
Novelty:  0.03196973
Score:  0.623
Data Source:  STRINGDB
MED4
Tbio
Family:  Enzyme
Novelty:  0.01200585
Score:  0.547
Data Source:  STRINGDB
CFLAR
Tbio
Novelty:  0.00108805
Score:  0.54
Data Source:  STRINGDB
SCNM1
Tbio
Novelty:  0.19700548
Score:  0.532
Data Source:  STRINGDB
Publication Statistics
PubMed Score  84.24

PubMed score by year
PubTator Score  37.93

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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