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Tbio
ARIH2
E3 ubiquitin-protein ligase ARIH2

Protein Summary
Description
E3 ubiquitin-protein ligase, which catalyzes ubiquitination of target proteins together with ubiquitin-conjugating enzyme E2 UBE2L3 (PubMed:16118314, PubMed:17646546, PubMed:19340006, PubMed:24076655). Acts as an atypical E3 ubiquitin-protein ligase by working together with cullin-5-RING ubiquitin ligase complex (ECS complex, also named CRL5 complex) and initiating ubiquitination of ECS substrates: associates with ECS complex and specifically mediates addition of the first ubiquitin on ECS targets (By similarity). The initial ubiquitin is then elongated (By similarity). E3 ubiquitin-protein ligase activity is activated upon binding to neddylated form of the ECS complex (PubMed:24076655). Mediates 'Lys-6', 'Lys-48'-and 'Lys-63'-linked polyubiquitination (PubMed:16118314, PubMed:17646546, PubMed:19340006). May play a role in myelopoiesis (PubMed:19340006). The protein encoded by this gene is an E3 ubiquitin-protein ligase that polyubiquitinates some proteins, tagging them for degradation ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000356401
  • ENSP00000348769
  • ENSG00000177479
  • ENST00000449376
  • ENSP00000403222

Symbol
  • ARI2
  • TRIAD1
  • ARI2
  • TRIAD1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
1
transcription factor perturbation
1
virus perturbation
0.98
disease perturbation
0.97
histone modification site profile
0.87


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.88   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 318   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.88   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 318   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (283)
UBE2L6
Tbio
Novelty:  0.03471633
p_int:  0.999999896
p_ni:  8.7e-8
p_wrong:  1.7e-8
Score:  0.953
Data Source:  BioPlex,STRINGDB
BMX
Tchem
Family:  Kinase
Novelty:  0.00383533
p_int:  0.999957772
p_ni:  0.000042194
p_wrong:  3.4e-8
Score:  0.235
Data Source:  BioPlex,STRINGDB
SOCS6
Tbio
Novelty:  0.00993375
p_int:  0.999660154
p_ni:  0.000055971
p_wrong:  0.000283875
Score:  0.249
Data Source:  BioPlex,STRINGDB
TULP3
Tbio
Family:  TF
Novelty:  0.06911636
p_int:  0.999193275
p_ni:  0.000286593
p_wrong:  0.000520131
Data Source:  BioPlex
ASB9
Tbio
Novelty:  0.18287435
p_int:  0.998993768
p_ni:  0.000206592
p_wrong:  0.00079964
Score:  0.927
Data Source:  BioPlex,STRINGDB
WSB2
Tbio
Novelty:  0.03939755
p_int:  0.992360729
p_ni:  0.007003932
p_wrong:  0.00063534
Score:  0.204
Data Source:  BioPlex,STRINGDB
UBE2N
Tchem
Novelty:  0.00620946
Score:  0.959
Data Source:  STRINGDB
UBC
Tbio
Novelty:  0.00204643
Score:  0.945
Data Source:  STRINGDB
ASB7
Tdark
Novelty:  0.21883348
Score:  0.944
Data Source:  STRINGDB
CUL5
Tbio
Novelty:  0.00792494
Score:  0.941
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
Immune System
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (19)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
HbA1c measurement
1
2
2
85.8
eosinophil count
1
1
1
81
cigarettes per day measurement
2
2
2
80.3
reticulocyte measurement
2
2
2
79.2
BMI-adjusted waist-hip ratio
1
1
1
75.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
HbA1c measurement
2
85.8
eosinophil count
1
81
cigarettes per day measurement
2
80.3
reticulocyte measurement
2
79.2
BMI-adjusted waist-hip ratio
1
75.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ariadne RBR E3 ubiquitin protein ligase 2
VGNC:11323
460355
Mouse
MGI:1344361
23807
Rat
RGD:1305839
316005
Dog
ariadne RBR E3 ubiquitin protein ligase 2
VGNC:38103
476633
Horse
ariadne RBR E3 ubiquitin protein ligase 2
VGNC:15506
100053691
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ariadne RBR E3 ubiquitin protein ligase 2
Mouse
Rat
Dog
ariadne RBR E3 ubiquitin protein ligase 2
Horse
ariadne RBR E3 ubiquitin protein ligase 2
Publication Statistics
PubMed Score 35.88
PubMed score by year
PubTator Score 21.42
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title