Tbio ARIH2 E3 ubiquitin-protein ligase ARIH2

Protein Summary

Description

E3 ubiquitin-protein ligase, which catalyzes ubiquitination of target proteins together with ubiquitin-conjugating enzyme E2 UBE2L3 (PubMed:16118314, PubMed:17646546, PubMed:19340006, PubMed:24076655). Acts as an atypical E3 ubiquitin-protein ligase by working together with cullin-5-RING ubiquitin ligase complex (ECS complex, also named CRL5 complex) and initiating ubiquitination of ECS substrates: associates with ECS complex and specifically mediates addition of the first ubiquitin on ECS targets (By similarity). The initial ubiquitin is then elongated (By similarity). E3 ubiquitin-protein ligase activity is activated upon binding to neddylated form of the ECS complex (PubMed:24076655). Mediates 'Lys-6', 'Lys-48'-and 'Lys-63'-linked polyubiquitination (PubMed:16118314, PubMed:17646546, PubMed:19340006). May play a role in myelopoiesis (PubMed:19340006). The protein encoded by this gene is an E3 ubiquitin-protein ligase that polyubiquitinates some proteins, tagging them for degradation. The encoded protein upregulates p53 in some cancer cells and may inhibit myelopoiesis. Several transcript variants encoding different isoforms have been found for this gene, although the full-length nature of some of them have not been determined yet. [provided by RefSeq, Nov 2015]

Uniprot Accession IDs

• O95376
• Q9HBZ6
• Q9UEM9
• ARI-2

Gene Name

• ARIH2

Ensembl ID

• ENST00000356401
• ENSP00000348769
• ENSG00000177479
• ENST00000449376
• ENSP00000403222

Symbol

• ARI2
• TRIAD1
• ARI2
• TRIAD1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	1
transcription factor perturbation	1
virus perturbation	0.98
disease perturbation	0.97
histone modification site profile	0.87

Protein Classes

PANTHER Classes

Protein / Ligase / Ubiquitin-protein Ligase / E3 Ubiquitin-protein Ligase Arih2

DTO Classes

Protein / Enzyme / Ligase / Ubiquitin-protein Ligase / E3 Ubiquitin-protein Ligase Arih2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.88   (req: < 5)

Gene RIFs: 11   (req: <= 3)

Antibodies: 318   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.88   (req: >= 5)

Gene RIFs: 11   (req: > 3)

Antibodies: 318   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

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Target Illumination GWAS Analytics (TIGA)

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (283)

Explore Interacting Targets

1 – 10 of 283

• See Interactions on String-DB

UBE2L6

Tbio

Novelty:  0.03471633

p_int:  0.999999896

p_ni:  8.7e-8

p_wrong:  1.7e-8

Score:  0.953

Data Source:  BioPlex,STRINGDB

BMX

Tchem

Family:  Kinase

Novelty:  0.00383533

p_int:  0.999957772

p_ni:  0.000042194

p_wrong:  3.4e-8

Score:  0.235

Data Source:  BioPlex,STRINGDB

SOCS6

Tbio

Novelty:  0.00993375

p_int:  0.999660154

p_ni:  0.000055971

p_wrong:  0.000283875

Score:  0.249

Data Source:  BioPlex,STRINGDB

TULP3

Tbio

Family:  TF

Novelty:  0.06911636

p_int:  0.999193275

p_ni:  0.000286593

p_wrong:  0.000520131

Data Source:  BioPlex

ASB9

Tbio

Novelty:  0.18287435

p_int:  0.998993768

p_ni:  0.000206592

p_wrong:  0.00079964

Score:  0.927

Data Source:  BioPlex,STRINGDB

WSB2

Tbio

Novelty:  0.03939755

p_int:  0.992360729

p_ni:  0.007003932

p_wrong:  0.00063534

Score:  0.204

Data Source:  BioPlex,STRINGDB

UBE2N

Tchem

Novelty:  0.00620946

Score:  0.959

Data Source:  STRINGDB

UBC

Tbio

Novelty:  0.00204643

Score:  0.945

Data Source:  STRINGDB

ASB7

Tdark

Novelty:  0.21883348

Score:  0.944

Data Source:  STRINGDB

CUL5

Tbio

Novelty:  0.00792494

Score:  0.941

Data Source:  STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (5)

Reactome (4)

UniProt (1)

Adaptive Immune System (R-HSA-1280218)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Adaptive Immune System	894 targets	R-HSA-1280218
Reactome	Antigen processing: Ubiquitination & Proteasome degradation	307 targets	R-HSA-983168
Reactome	Class I MHC mediated antigen processing & presentation	437 targets	R-HSA-983169
Reactome	Immune System	2246 targets	R-HSA-168256

Name	Explore in Pharos	Explore in Source
Adaptive Immune System	894 targets	R-HSA-1280218
Antigen processing: Ubiquitination & Proteasome degradation	307 targets	R-HSA-983168
Class I MHC mediated antigen processing & presentation	437 targets	R-HSA-983169
Immune System	2246 targets	R-HSA-168256

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (18)

Functions (4)

Components (4)

Processes (10)

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1 – 4 of 4

GO Term	Evidence	Assigned by
ubiquitin-protein transferase activity	Inferred from Direct Assay (IDA)	UniProtKB
ubiquitin conjugating enzyme binding	Inferred from Physical Interaction (IPI)	UniProtKB
ubiquitin protein ligase activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
zinc ion binding	Traceable Author Statement (TAS)	ProtInc

Disease Associations ()

No disease associations found

GWAS Traits (19)

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1 – 5 of 19

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
HbA1c measurement	EFO_0004541	1	2	2		85.8
eosinophil count	EFO_0004842	1	1	1		81
cigarettes per day measurement	EFO_0006525	2	2	2		80.3
reticulocyte measurement	EFO_0010700	2	2	2		79.2
BMI-adjusted waist-hip ratio	EFO_0007788	1	1	1		75.1

• Explore on Target Illumination GWAS Analytics (TIGA)

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1 – 5 of 19

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
HbA1c measurement	EFO_0004541	2		85.8
eosinophil count	EFO_0004842	1		81
cigarettes per day measurement	EFO_0006525	2		80.3
reticulocyte measurement	EFO_0010700	2		79.2
BMI-adjusted waist-hip ratio	EFO_0007788	1		75.1

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UniProt Keyword Find Similar Targets

No Header	No Header
Complete proteome
Cytoplasm
Metal-binding
Nucleus
Phosphoprotein
Polymorphism
Reference proteome
Repeat
Transferase
Ubl conjugation

GWAS Trait Find Similar Targets

No Header	No Header
BMI-adjusted waist circumference
BMI-adjusted waist-hip ratio
chronotype measurement
cigarettes per day measurement
creatinine measurement
eosinophil count
eosinophil percentage of leukocytes
glomerular filtration rate
HbA1c measurement
insomnia measurement

MGI Phenotype Find Similar Targets

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behavior/neurological phenotype
cardiovascular system phenotype
cellular phenotype
embryo phenotype
endocrine/exocrine gland phenotype
growth/size/body region phenotype
homeostasis/metabolism phenotype
immune system phenotype
integument phenotype
liver/biliary system phenotype

IDG Resources

No IDG generated resources found

Orthologs (16)

1 – 5 of 16

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	ariadne RBR E3 ubiquitin protein ligase 2	VGNC:11323	460355
Mouse	ariadne RBR E3 ubiquitin protein ligase 2	MGI:1344361	23807
Rat	ariadne RBR E3 ubiquitin protein ligase 2	RGD:1305839	316005
Dog	ariadne RBR E3 ubiquitin protein ligase 2	VGNC:38103	476633
Horse	ariadne RBR E3 ubiquitin protein ligase 2	VGNC:15506	100053691

Species	Name	OMA	EggNOG	Inparanoid
Chimp	ariadne RBR E3 ubiquitin protein ligase 2
Mouse	ariadne RBR E3 ubiquitin protein ligase 2
Rat	ariadne RBR E3 ubiquitin protein ligase 2
Dog	ariadne RBR E3 ubiquitin protein ligase 2
Horse	ariadne RBR E3 ubiquitin protein ligase 2

Publication Statistics

PubMed Score 35.88

PubMed score by year

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PubTator Score 21.42

PubTator score by year

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Related Publications

Text Mined References (27)

GeneRif Annotations (11)

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PMID	Year	Title