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Tchem
FARS2
Phenylalanine--tRNA ligase, mitochondrial

Protein Summary
Description
Is responsible for the charging of tRNA(Phe) with phenylalanine in mitochondrial translation. To a lesser extent, also catalyzes direct attachment of m-Tyr (an oxidized version of Phe) to tRNA(Phe), thereby opening the way for delivery of the misacylated tRNA to the ribosome and incorporation of ROS-damaged amino acid into proteins. This gene encodes a protein that transfers phenylalanine to its cognate tRNA. This protein localizes to the mitochondrion and plays a role in mitochondrial protein translation. Mutations in this gene can cause combined oxidative phosphorylation deficiency 14 (Alpers encephalopathy). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000274680
  • ENSP00000274680
  • ENSG00000145982
  • ENST00000324331
  • ENSP00000316335

Symbol
  • FARS1
  • FARS1
  • PheRS
  • SPG77
  • COXPD14
  • HSPC320
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.96
disease perturbation
0.95
histone modification site profile
0.9
transcription factor binding site profile
0.85
trait
0.75


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 153.46   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 119   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 153.46   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 119   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (100)
MRPL38
Tdark
Novelty:  0.71587283
p_int:  0.999974214
p_ni:  0.000025786
Score:  0.199
Data Source:  BioPlex,STRINGDB
GAMT
Tbio
Family:  Enzyme
Novelty:  0.00656642
p_int:  0.997157187
p_ni:  0.002842813
Score:  0.326
Data Source:  BioPlex,STRINGDB
RPS16
Tbio
Novelty:  0.00261983
p_int:  0.982508647
p_ni:  0.017491353
Score:  0.237
Data Source:  BioPlex,STRINGDB
NDUFV3
Tclin
Family:  Enzyme
Novelty:  0.15352039
p_int:  0.974326719
p_ni:  0.025673281
Data Source:  BioPlex
HIST1H1A
Tbio
Novelty:  0.00123818
p_int:  0.966036854
p_ni:  0.033963021
p_wrong:  1.25e-7
Score:  0.194
Data Source:  BioPlex,STRINGDB
NPPB
Tbio
Novelty:  0.00024947
p_int:  0.964471999
p_ni:  0.035528001
Data Source:  BioPlex
ZKSCAN8
Tbio
Family:  TF
Novelty:  0.17881042
p_int:  0.946900356
p_ni:  0.053099644
Data Source:  BioPlex
HIST1H1E
Tbio
Novelty:  0.01125284
p_int:  0.912729527
p_ni:  0.087270473
Score:  0.204
Data Source:  BioPlex,STRINGDB
HIST1H1T
Tdark
Novelty:  0.01039464
p_int:  0.863647306
p_ni:  0.136351516
p_wrong:  0.000001178
Score:  0.203
Data Source:  BioPlex,STRINGDB
HNRNPA1
Tchem
Novelty:  0.0020871
p_int:  0.844465208
p_ni:  0.155534785
p_wrong:  7e-9
Score:  0.174
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
Metabolism of proteins (R-HSA-392499)

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Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Mitochondrial tRNA aminoacylation
Reactome
Translation
Reactome
tRNA Aminoacylation
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Mitochondrial tRNA aminoacylation
Translation
tRNA Aminoacylation
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
2
1
2
67.5
body weight
1
1
1
13.5
gut microbiome measurement
1
1
1
4.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
2
67.5
body weight
1
13.5
gut microbiome measurement
1
4.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
phenylalanyl-tRNA synthetase 2, mitochondrial
VGNC:8720
462410
Macaque
phenylalanyl-tRNA synthetase 2, mitochondrial
710945
Mouse
MGI:1917205
69955
Rat
RGD:1309416
306879
Dog
phenylalanyl-tRNA synthetase 2, mitochondrial
VGNC:40732
488204
Species
Name
OMA
EggNOG
Inparanoid
Chimp
phenylalanyl-tRNA synthetase 2, mitochondrial
Macaque
phenylalanyl-tRNA synthetase 2, mitochondrial
Mouse
Rat
Dog
phenylalanyl-tRNA synthetase 2, mitochondrial
Publication Statistics
PubMed Score 153.46
PubMed score by year
PubTator Score 17.64
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title