Tbio TRIM16 Tripartite motif-containing protein 16

Protein Summary

Description

E3 ubiquitin ligase that plays an essential role in the organization of autophagic response and ubiquitination upon lysosomal and phagosomal damages. Plays a role in the stress-induced biogenesis and degradation of protein aggresomes by regulating the p62-KEAP1-NRF2 signaling and particularly by modulating the ubiquitination levels and thus stability of NRF2. Acts as a scaffold protein and facilitates autophagic degradation of protein aggregates by interacting with p62/SQSTM, ATG16L1 and LC3B/MAP1LC3B. In turn, protects the cell against oxidative stress-induced cell death as a consequence of endomembrane damage. The protein encoded by this gene is a tripartite motif (TRIM) family member that contains two B box domains and a coiled-coiled region that are characteristic of the B box zinc finger protein family. While it lacks a RING domain found in other TRIM proteins, the encoded protein can homodimerize or heterodimerize with other TRIM proteins and has E3 ubiquitin ligase activity. This gene is also a tumor suppressor and is involved in secretory autophagy. [provided by RefSeq, Jan 2017]

Uniprot Accession IDs

• O95361
• Q6IAL8
• Q7Z6I2
• Q96BE8
• Q96J43

Gene Name

• TRIM16

Ensembl ID

• ENST00000336708
• ENSP00000338989
• ENSG00000221926
• ENST00000577886
• ENSP00000462903
• ENST00000578237
• ENSP00000463188
• ENST00000649191
• ENSP00000497185

Symbol

• EBBP
• EBBP

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.87
protein domain	0.85
small molecule perturbation	0.76
transcription factor perturbation	0.74
cell type or tissue	0.72

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 51.36   (req: < 5)

Gene RIFs: 29   (req: <= 3)

Antibodies: 219   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 51.36   (req: >= 5)

Gene RIFs: 29   (req: > 3)

Antibodies: 219   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0