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Tbio
TACC2
Transforming acidic coiled-coil-containing protein 2

Protein Summary
Description
Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By similarity). May play a role in organizing centrosomal microtubules. May act as a tumor suppressor protein. May represent a tumor progression marker. Transforming acidic coiled-coil proteins are a conserved family of centrosome- and microtubule-interacting proteins that are implicated in cancer. This gene encodes a protein that concentrates at centrosomes throughout the cell cycle. This gene lies within a chromosomal region associated with tumorigenesis. Expression of this gene is induced by erythropoietin and is thought to affect the progression of breast tumors. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000260733
  • ENSP00000260733
  • ENSG00000138162
  • ENST00000334433
  • ENSP00000334280
  • ENST00000358010
  • ENSP00000350701
  • ENST00000360561
  • ENSP00000353763
  • ENST00000369000
  • ENSP00000357996
  • ENST00000369005
  • ENSP00000358001
  • ENST00000513429
  • ENSP00000425062

Symbol
  • AZU-1
  • ECTACC
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.98
co-expressed gene
0.93
transcription factor
0.79
kinase perturbation
0.76
PubMedID
0.74


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.34   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 195   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.34   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 195   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
1
2
34.2
bone density
1
1
2
5.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
34.2
bone density
2
5.5
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
transforming acidic coiled-coil containing protein 2
VGNC:7266
742328
Macaque
transforming acidic coiled-coil containing protein 2
705497
Mouse
MGI:1928899
57752
Rat
RGD:1303004
309025
Dog
transforming acidic coiled-coil containing protein 2
VGNC:47064
477850
Species
Name
OMA
EggNOG
Inparanoid
Chimp
transforming acidic coiled-coil containing protein 2
Macaque
transforming acidic coiled-coil containing protein 2
Mouse
Rat
Dog
transforming acidic coiled-coil containing protein 2
Protein Structure (0 Structures, 9 AlphaFold Models)
RepresentationColor Scheme

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (10)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Protein-Protein Interactions (55)
1 – 10 of 55
TACC1
Tbio
Novelty: 0.03556945
p_int: 1
Score: 0.635
Data Source: BioPlex,STRINGDB
CKAP5
Tbio
Novelty: 0.00623771
Score: 0.981
Data Source: STRINGDB
AURKC
Tchem
Family: Kinase
Novelty: 0.00950433
Score: 0.815
Data Source: STRINGDB
YEATS4
Tbio
Novelty: 0.02632024
Score: 0.735
Data Source: STRINGDB
ZNF780B
Tdark
Family: TF
Novelty: 2.3984392
Score: 0.732
Data Source: STRINGDB
TRIOBP
Tbio
Novelty: 0.04145641
Score: 0.697
Data Source: STRINGDB
ZNF780A
Tdark
Family: TF
Novelty: 2.95830815
Score: 0.634
Data Source: STRINGDB
UBTF
Tbio
Family: TF
Novelty: 0.00421069
Score: 0.628
Data Source: STRINGDB
COIL
Tbio
Novelty: 0.00616248
Score: 0.624
Data Source: STRINGDB
AURKA
Tchem
Family: Kinase
Novelty: 0.0010868
Score: 0.594
Data Source: STRINGDB
Publication Statistics
PubMed Score  21.34

PubMed score by year
PubTator Score  16.6

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer