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Tchem
ATG7
Ubiquitin-like modifier-activating enzyme ATG7

Protein Summary
Description
E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Modulates p53/TP53 activity to regulate cell cycle and survival during metabolic stress. Plays also a key role in the maintenance of axonal homeostasis, the prevention of axonal degeneration, the maintenance of hematopoietic stem cells, the formation of Paneth cell granules, as well as in adipose differentiation. Plays a role in regulating the liver clock an ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000354449
  • ENSP00000346437
  • ENSG00000197548
  • ENST00000354956
  • ENSP00000347042
  • ENST00000446450
  • ENSP00000412580

Symbol
  • APG7L
  • GSA7
  • APG7L
  • APG7-LIKE
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
interacting protein
1
transcription factor perturbation
0.96
transcription factor binding site profile
0.84
virus perturbation
0.68


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 864.68   (req: < 5)
Gene RIFs: 50   (req: <= 3)
Antibodies: 720   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 864.68   (req: >= 5)
Gene RIFs: 50   (req: > 3)
Antibodies: 720   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 35
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 190
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (521)
ATG3
Tbio
Novelty:  0.00541077
p_int:  0.999999999
p_ni:  1e-9
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
ATP23
Tbio
Family:  Enzyme
Novelty:  0.09823059
p_int:  0.999996741
p_ni:  0.000003259
Score:  0.203
Data Source:  BioPlex,STRINGDB
TXLNB
Tbio
Novelty:  0.12751933
p_int:  0.999995512
p_ni:  0.000004488
Score:  0.16
Data Source:  BioPlex,STRINGDB
KHDRBS2
Tbio
Novelty:  0.01986638
p_int:  0.999963734
p_ni:  0.000036265
p_wrong:  1e-9
Score:  0.171
Data Source:  BioPlex,STRINGDB
RIPK1
Tchem
Family:  Kinase
Novelty:  0.00230565
p_int:  0.99993832
p_ni:  0.00006168
Score:  0.533
Data Source:  BioPlex,STRINGDB
ATG10
Tbio
Novelty:  0.0167153
p_int:  0.999928267
p_ni:  0.000071733
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
RWDD2A
Tdark
Novelty:  0.39863218
p_int:  0.997260945
p_ni:  0.002739055
Score:  0.275
Data Source:  BioPlex,STRINGDB
RNF181
Tbio
Family:  Enzyme
Novelty:  0.27482636
p_int:  0.991938075
p_ni:  0.008061924
Data Source:  BioPlex
STXBP6
Tbio
Novelty:  0.13195671
p_int:  0.990202658
p_ni:  0.009797328
p_wrong:  1.3e-8
Score:  0.158
Data Source:  BioPlex,STRINGDB
TTR
Tclin
Novelty:  0.0001199
p_int:  0.972243539
p_ni:  0.027756379
p_wrong:  8.2e-8
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (21)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 13
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Autophagy
Reactome
Cellular responses to external stimuli
Reactome
Class I MHC mediated antigen processing & presentation
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Autophagy
Cellular responses to external stimuli
Class I MHC mediated antigen processing & presentation
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (43)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Disease Associations (null)
No disease associations found
GWAS Traits (20)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
3
3
4
91.9
BMI-adjusted hip circumference
2
10
10
85.4
hip circumference
2
7
7
73
balding measurement
1
1
1
72.5
comparative body size at age 10, self-reported
1
1
1
68.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
4
91.9
BMI-adjusted hip circumference
10
85.4
hip circumference
7
73
balding measurement
1
72.5
comparative body size at age 10, self-reported
1
68.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
autophagy related 7
VGNC:11326
470747
Macaque
autophagy related 7
696238
Mouse
MGI:1921494
74244
Rat
RGD:1304817
312647
Dog
autophagy related 7
VGNC:38227
476533
Species
Name
OMA
EggNOG
Inparanoid
Chimp
autophagy related 7
Macaque
autophagy related 7
Mouse
Rat
Dog
autophagy related 7
Publication Statistics
PubMed Score 864.68
PubMed score by year
PubTator Score 272.35
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title