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Tchem
SMC2
Structural maintenance of chromosomes protein 2

Protein Summary
Description
Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000286398
  • ENSP00000286398
  • ENSG00000136824
  • ENST00000374787
  • ENSP00000363919
  • ENST00000374793
  • ENSP00000363925

Symbol
  • CAPE
  • SMC2L1
  • CAPE
  • CAP-E
  • SMC-2
  • SMC2L1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.9
protein complex
0.88
co-expressed gene
0.82
molecular function
0.81
cellular component
0.8


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.4   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 238   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.4   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 238   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (323)
NCAPH2
Tbio
Novelty:  0.12134933
p_int:  0.999832518
p_ni:  0.000167482
Score:  0.998
Data Source:  BioPlex,STRINGDB
LZTS2
Tbio
Novelty:  0.09515452
p_int:  0.936209054
p_ni:  0.063790946
Data Source:  BioPlex
SYNE4
Tbio
Novelty:  0.0739848
p_int:  0.935640732
p_ni:  0.064359268
Data Source:  BioPlex
PSMC4
Tchem
Family:  Enzyme
Novelty:  0.01717597
p_int:  0.930460349
p_ni:  0.069539651
Score:  0.207
Data Source:  BioPlex,STRINGDB
EPHA1
Tchem
Family:  Kinase
Novelty:  0.00136672
p_int:  0.900966589
p_ni:  0.099033411
Score:  0.174
Data Source:  BioPlex,STRINGDB
BMP1
Tchem
Novelty:  0.00299518
p_int:  0.889404409
p_ni:  0.110595591
Data Source:  BioPlex
FZD10
Tbio
Family:  GPCR
Novelty:  0.02786933
p_int:  0.838827088
p_ni:  0.161172912
Data Source:  BioPlex
GPR137B
Tbio
Novelty:  0.17325252
p_int:  0.823212698
p_ni:  0.176787302
Score:  0.219
Data Source:  BioPlex,STRINGDB
DPEP1
Tclin
Family:  Enzyme
Novelty:  0.00384946
p_int:  0.795517737
p_ni:  0.204482263
Data Source:  BioPlex
C1QL4
Tdark
Novelty:  0.37071722
p_int:  0.771897549
p_ni:  0.228102451
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (59)
Cell Cycle (R-HSA-1640170)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell Cycle
Reactome
Cell Cycle, Mitotic
Reactome
Condensation of Prometaphase Chromosomes
Reactome
Condensation of Prophase Chromosomes
Reactome
M Phase
Name
Explore in Pharos
Explore in Source
Cell Cycle
Cell Cycle, Mitotic
Condensation of Prometaphase Chromosomes
Condensation of Prophase Chromosomes
M Phase
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
2
1
1.1
50.6
1
1
0
1
17.8
keratinocyte carcinoma
1
1
0
1.1
15.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1.1
50.6
0
1
17.8
keratinocyte carcinoma
0
1.1
15.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
structural maintenance of chromosomes 2
VGNC:4864
464627
Macaque
structural maintenance of chromosomes 2
713359
Mouse
MGI:106067
14211
Rat
RGD:1305227
362519
Dog
structural maintenance of chromosomes 2
VGNC:46543
481637
Species
Name
OMA
EggNOG
Inparanoid
Chimp
structural maintenance of chromosomes 2
Macaque
structural maintenance of chromosomes 2
Mouse
Rat
Dog
structural maintenance of chromosomes 2
Publication Statistics
PubMed Score 14.40
PubMed score by year
PubTator Score 204.16
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title