Tchem SMC2 Structural maintenance of chromosomes protein 2

Protein Summary

Description

Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.

Uniprot Accession IDs

• O95347
• Q6IEE0
• Q9P1P2
• SMC protein 2

Gene Name

• SMC2

Ensembl ID

• ENST00000286398
• ENSP00000286398
• ENSG00000136824
• ENST00000374787
• ENSP00000363919
• ENST00000374793
• ENSP00000363925

Symbol

• CAPE
• SMC2L1
• CAPE
• CAP-E
• SMC-2
• SMC2L1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.9
protein complex	0.88
co-expressed gene	0.82
molecular function	0.81
cellular component	0.8

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.37   (req: < 5)

Gene RIFs: 10   (req: <= 3)

Antibodies: 238   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.37   (req: >= 5)

Gene RIFs: 10   (req: > 3)

Antibodies: 238   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1