Protein Summary
Involved in the ATP-dependent secretion of bile salts into the canaliculus of hepatocytes. The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is the major canalicular bile salt export pump in man. Mutations in this gene cause a form of progressive familial intrahepatic cholestases which are a group of inherited disorders with severe cholestatic liver disease from early infancy. [provided by RefSeq, Jul 2008]
- ENST00000263817
- ENSP00000263817
- ENSG00000073734
- ENST00000650372
- ENSP00000497931
- BSEP
- BSEP
- PGY4
- SPGP
- ABC16
- BRIC2
- PFIC2
- PFIC-2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
chemical | 1 | ||
molecular function | 1 | ||
drug | 0.98 | ||
trait | 0.93 | ||
protein domain | 0.85 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1104.7 (req: < 5)
Gene RIFs: 100 (req: <= 3)
Antibodies: 218 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1104.7 (req: >= 5)
Gene RIFs: 100 (req: > 3)
Antibodies: 218 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 8
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 4
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 2
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (2)
Active Ligands (4)
Protein-Protein Interactions (95)
Nearest Tclin Targets (1)
Upstream (1)
1 – 1 of 1
Pathways (20)
Reactome (11)
KEGG (4)
WikiPathways (5)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | ABC transporter disorders | ||||
Reactome | Bile acid and bile salt metabolism | ||||
Reactome | Defective ABCB11 causes progressive familial intrahepatic cholestasis 2 and benign recurrent intrahepatic cholestasis 2 | ||||
Reactome | Disease | ||||
Reactome | Disorders of transmembrane transporters | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
ABC transporter disorders | ||||
Bile acid and bile salt metabolism | ||||
Defective ABCB11 causes progressive familial intrahepatic cholestasis 2 and benign recurrent intrahepatic cholestasis 2 | ||||
Disease | ||||
Disorders of transmembrane transporters | ||||
Viral Interactions (0)
Gene Ontology Terms (12)
Functions (5)
Components (4)
Processes (3)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Traceable Author Statement (TAS) | ProtInc | |||
Traceable Author Statement (TAS) | Reactome | |||
Traceable Author Statement (TAS) | ProtInc | |||
Traceable Author Statement (TAS) | ProtInc | |||
Disease Associations ()
GWAS Traits (42)
Items per page:
1 – 5 of 42
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
glucose measurement | 8 | 25 | 28 | 100 | |||||
HbA1c measurement | 12 | 22 | 26 | 99.9 | |||||
fasting blood glucose measurement | 16 | 8 | 20 | 1.3 | 99.6 | ||||
serum gamma-glutamyl transferase measurement | 3 | 6 | 6 | 94 | |||||
serum alanine aminotransferase measurement | 3 | 3 | 2 | 10.7 | 92.3 | ||||
Items per page:
1 – 5 of 42
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
glucose measurement | 28 | 100 | |||||
HbA1c measurement | 26 | 99.9 | |||||
fasting blood glucose measurement | 20 | 1.3 | 99.6 | ||||
serum gamma-glutamyl transferase measurement | 6 | 94 | |||||
serum alanine aminotransferase measurement | 2 | 10.7 | 92.3 | ||||
Find similar targets by:
IDG Resources
Orthologs (11)
1 – 5 of 11
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Macaque | ATP binding cassette subfamily B member 11 | 709261 | ||||||
Mouse | MGI:1351619 | 27413 | ||||||
Rat | RGD:619930 | 83569 | ||||||
Dog | ATP binding cassette subfamily B member 11 | VGNC:37433 | 488390 | |||||
Horse | ATP binding cassette subfamily B member 11 | VGNC:14909 | 100052359 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Macaque | ATP binding cassette subfamily B member 11 | |||||
Mouse | ||||||
Rat | ||||||
Dog | ATP binding cassette subfamily B member 11 | |||||
Horse | ATP binding cassette subfamily B member 11 | |||||
Publication Statistics
PubMed Score 1104.70
PubMed score by year
PubTator Score 546.76
PubTator score by year
Related Publications
Text Mined References (127)
GeneRif Annotations (100)
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0 of 0
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