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Tchem
ABCB11
Bile salt export pump

Protein Summary
Description
Involved in the ATP-dependent secretion of bile salts into the canaliculus of hepatocytes. The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is the major canalicular bile salt export pump in man. Mutations in this gene cause a form of progressive familial intrahepatic cholestases which are a group of inherited disorders with severe cholestatic liver disease from early infancy. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000263817
  • ENSP00000263817
  • ENSG00000073734
  • ENST00000650372
  • ENSP00000497931

Symbol
  • BSEP
  • BSEP
  • PGY4
  • SPGP
  • ABC16
  • BRIC2
  • PFIC2
  • PFIC-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
chemical
1
molecular function
1
drug
0.98
trait
0.93
protein domain
0.85


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1104.7   (req: < 5)
Gene RIFs: 100   (req: <= 3)
Antibodies: 218   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1104.7   (req: >= 5)
Gene RIFs: 100   (req: > 3)
Antibodies: 218   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 4
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2
GWAS Traits (42)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glucose measurement
8
25
28
100
HbA1c measurement
12
22
26
99.9
fasting blood glucose measurement
16
8
20
1.3
99.6
serum gamma-glutamyl transferase measurement
3
6
6
94
serum alanine aminotransferase measurement
3
3
2
10.7
92.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glucose measurement
28
100
HbA1c measurement
26
99.9
fasting blood glucose measurement
20
1.3
99.6
serum gamma-glutamyl transferase measurement
6
94
serum alanine aminotransferase measurement
2
10.7
92.3
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
ATP binding cassette subfamily B member 11
709261
Mouse
MGI:1351619
27413
Rat
RGD:619930
83569
Dog
ATP binding cassette subfamily B member 11
VGNC:37433
488390
Horse
ATP binding cassette subfamily B member 11
VGNC:14909
100052359
Species
Name
OMA
EggNOG
Inparanoid
Macaque
ATP binding cassette subfamily B member 11
Mouse
Rat
Dog
ATP binding cassette subfamily B member 11
Horse
ATP binding cassette subfamily B member 11
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-O95342-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (20)
ABC transporter disorders (R-HSA-5619084)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ABC transporter disorders
Reactome
Bile acid and bile salt metabolism
Reactome
Defective ABCB11 causes progressive familial intrahepatic cholestasis 2 and benign recurrent intrahepatic cholestasis 2
Reactome
Disease
Reactome
Disorders of transmembrane transporters
Name
Explore in Pharos
Explore in Source
ABC transporter disorders
Bile acid and bile salt metabolism
Defective ABCB11 causes progressive familial intrahepatic cholestasis 2 and benign recurrent intrahepatic cholestasis 2
Disease
Disorders of transmembrane transporters
Gene Ontology Terms (12)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (95)
1 – 10 of 95
NR1H4
Tclin
Family:  NR
Novelty:  0.00067092
Score:  0.955
Data Source:  STRINGDB
SLC10A1
Tclin
Family:  Transporter
Novelty:  0.00142951
Score:  0.912
Data Source:  STRINGDB
ATP8B1
Tbio
Family:  Transporter
Novelty:  0.00793658
Score:  0.911
Data Source:  STRINGDB
CYP7A1
Tchem
Family:  Enzyme
Novelty:  0.00148194
Score:  0.861
Data Source:  STRINGDB
NR0B2
Tchem
Family:  NR
Novelty:  0.0009861
Score:  0.832
Data Source:  STRINGDB
SLCO1B1
Tchem
Family:  Transporter
Novelty:  0.00126613
Score:  0.812
Data Source:  STRINGDB
CYP8B1
Tchem
Family:  Enzyme
Novelty:  0.01243408
Score:  0.811
Data Source:  STRINGDB
SLCO1B3
Tchem
Family:  Transporter
Novelty:  0.0031518
Score:  0.78
Data Source:  STRINGDB
SLC10A2
Tclin
Family:  Transporter
Novelty:  0.0036213
Score:  0.757
Data Source:  STRINGDB
HAX1
Tbio
Novelty:  0.00749205
Score:  0.747
Data Source:  STRINGDB
Publication Statistics
PubMed Score  1104.70

PubMed score by year
PubTator Score  546.76

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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