Protein Summary
Involved in the ATP-dependent secretion of bile salts into the canaliculus of hepatocytes. The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is the major canalicular bile salt export pump in man. Mutations in this gene cause a form of progressive familial intrahepatic cholestases which are a group of inherited disorders with severe cholestatic liver disease from early infancy. [provided by RefSeq, Jul 2008]
- ENST00000263817
- ENSP00000263817
- ENSG00000073734
- ENST00000650372
- ENSP00000497931
- BSEP
- BSEP
- PGY4
- SPGP
- ABC16
- BRIC2
- PFIC2
- PFIC-2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
chemical | 1 | ||
molecular function | 1 | ||
drug | 0.98 | ||
trait | 0.93 | ||
protein domain | 0.85 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1359.73 (req: < 5)
Gene RIFs: 124 (req: <= 3)
Antibodies: 218 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1359.73 (req: >= 5)
Gene RIFs: 124 (req: > 3)
Antibodies: 218 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 8
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 4
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 2