Protein Classes
Protein Summary
Involved in the ATP-dependent secretion of bile salts into the canaliculus of hepatocytes. The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is the major canalicular bile salt export pump in man. Mutations in this gene cause a form of progressive familial intrahepatic cholestases which are a group of inherited disorders with severe cholestatic liver disease from early infancy. [provided by RefSeq, Jul 2008]
- ENST00000263817
- ENSP00000263817
- ENSG00000073734
- ENST00000650372
- ENSP00000497931
- BSEP
- BSEP
- PGY4
- SPGP
- ABC16
- BRIC2
- PFIC2
- PFIC-2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
chemical | 1 | ||
molecular function | 1 | ||
drug | 0.98 | ||
trait | 0.93 | ||
protein domain | 0.85 | ||
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1104.7 (req: < 5)
Gene RIFs: 100 (req: <= 3)
Antibodies: 218 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1104.7 (req: >= 5)
Gene RIFs: 100 (req: > 3)
Antibodies: 218 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 8
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 4
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 2
Approved Drugs (2)
1 – 2 of 2
Active Ligands (4)
1 – 4 of 4
GWAS Traits (42)
Items per page:
1 – 5 of 42
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
glucose measurement | 8 | 25 | 28 | 100 | |||||
HbA1c measurement | 12 | 22 | 26 | 99.9 | |||||
fasting blood glucose measurement | 16 | 8 | 20 | 1.3 | 99.6 | ||||
serum gamma-glutamyl transferase measurement | 3 | 6 | 6 | 94 | |||||
serum alanine aminotransferase measurement | 3 | 3 | 2 | 10.7 | 92.3 | ||||
Items per page:
1 – 5 of 42
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
glucose measurement | 28 | 100 | |||||
HbA1c measurement | 26 | 99.9 | |||||
fasting blood glucose measurement | 20 | 1.3 | 99.6 | ||||
serum gamma-glutamyl transferase measurement | 6 | 94 | |||||
serum alanine aminotransferase measurement | 2 | 10.7 | 92.3 | ||||
Orthologs (11)
1 – 5 of 11
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Macaque | ATP binding cassette subfamily B member 11 | 709261 | ||||||
Mouse | MGI:1351619 | 27413 | ||||||
Rat | RGD:619930 | 83569 | ||||||
Dog | ATP binding cassette subfamily B member 11 | VGNC:37433 | 488390 | |||||
Horse | ATP binding cassette subfamily B member 11 | VGNC:14909 | 100052359 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Macaque | ATP binding cassette subfamily B member 11 | |||||
Mouse | ||||||
Rat | ||||||
Dog | ATP binding cassette subfamily B member 11 | |||||
Horse | ATP binding cassette subfamily B member 11 | |||||
Protein Structure (0 Structures, 1 AlphaFold Model)
Pathways (20)
Reactome (11)
KEGG (4)
WikiPathways (5)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 11
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | ABC transporter disorders | ||||
Reactome | Bile acid and bile salt metabolism | ||||
Reactome | Defective ABCB11 causes progressive familial intrahepatic cholestasis 2 and benign recurrent intrahepatic cholestasis 2 | ||||
Reactome | Disease | ||||
Reactome | Disorders of transmembrane transporters | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
ABC transporter disorders | ||||
Bile acid and bile salt metabolism | ||||
Defective ABCB11 causes progressive familial intrahepatic cholestasis 2 and benign recurrent intrahepatic cholestasis 2 | ||||
Disease | ||||
Disorders of transmembrane transporters | ||||
Gene Ontology Terms (12)
Functions (5)
Components (4)
Processes (3)
Items per page:
10
1 – 5 of 5
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Traceable Author Statement (TAS) | ProtInc | |||
Traceable Author Statement (TAS) | Reactome | |||
Traceable Author Statement (TAS) | ProtInc | |||
Traceable Author Statement (TAS) | ProtInc | |||
Protein-Protein Interactions (95)
1 – 10 of 95
NR1H4
Family: NR
Novelty: 0.00067092
Score: 0.955
Data Source: STRINGDB
SLC10A1
Family: Transporter
Novelty: 0.00142951
Score: 0.912
Data Source: STRINGDB
ATP8B1
Family: Transporter
Novelty: 0.00793658
Score: 0.911
Data Source: STRINGDB
CYP7A1
Family: Enzyme
Novelty: 0.00148194
Score: 0.861
Data Source: STRINGDB
NR0B2
Family: NR
Novelty: 0.0009861
Score: 0.832
Data Source: STRINGDB
SLCO1B1
Family: Transporter
Novelty: 0.00126613
Score: 0.812
Data Source: STRINGDB
CYP8B1
Family: Enzyme
Novelty: 0.01243408
Score: 0.811
Data Source: STRINGDB
SLCO1B3
Family: Transporter
Novelty: 0.0031518
Score: 0.78
Data Source: STRINGDB
SLC10A2
Family: Transporter
Novelty: 0.0036213
Score: 0.757
Data Source: STRINGDB
HAX1
Novelty: 0.00749205
Score: 0.747
Data Source: STRINGDB
Publication Statistics
PubMed Score 1104.70
PubMed score by year
PubTator Score 546.76
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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UniProt Keyword
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GWAS Trait
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