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Tbio
PAPSS2
Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2

Protein Summary
Description
Bifunctional enzyme with both ATP sulfurylase and APS kinase activity, which mediates two steps in the sulfate activation pathway. The first step is the transfer of a sulfate group to ATP to yield adenosine 5'-phosphosulfate (APS), and the second step is the transfer of a phosphate group from ATP to APS yielding 3'-phosphoadenylylsulfate (PAPS: activated sulfate donor used by sulfotransferase). In mammals, PAPS is the sole source of sulfate; APS appears to be only an intermediate in the sulfate-activation pathway. May have a important role in skeletogenesis during postnatal growth (By similarity). Sulfation is a common modification of endogenous (lipids, proteins, and carbohydrates) and exogenous (xenobiotics and drugs) compounds. In mammals, the sulfate source is 3'-phosphoadenosine 5'-phosphosulfate (PAPS), created from ATP and inorganic sulfate. Two different tissue isoforms encoded by different genes synthesize PAPS. This gene encodes one of the two PAPS synthetases. Defects in thi ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000361175
  • ENSP00000354436
  • ENSG00000198682
  • ENST00000456849
  • ENSP00000406157

Symbol
  • ATPSK2
  • SK2
  • BCYM4
  • ATPSK2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
1
molecular function
0.94
protein domain
0.92
PubMedID
0.86
gene perturbation
0.85


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 60.41   (req: < 5)
Gene RIFs: 15   (req: <= 3)
Antibodies: 213   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 60.41   (req: >= 5)
Gene RIFs: 15   (req: > 3)
Antibodies: 213   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
3
4
5
84.3
BMI-adjusted waist-hip ratio
2
1
2
55.2
waist-hip ratio
2
1
2
53.3
BMI-adjusted hip circumference
1
1
1
24.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
5
84.3
BMI-adjusted waist-hip ratio
2
55.2
waist-hip ratio
2
53.3
BMI-adjusted hip circumference
1
24.5
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
3'-phosphoadenosine 5'-phosphosulfate synthase 2
VGNC:9751
466140
Macaque
3'-phosphoadenosine 5'-phosphosulfate synthase 2
704688
Mouse
MGI:1330223
23972
Rat
RGD:1307012
294103
Horse
3'-phosphoadenosine 5'-phosphosulfate synthase 2
VGNC:21154
100071740
Species
Name
OMA
EggNOG
Inparanoid
Chimp
3'-phosphoadenosine 5'-phosphosulfate synthase 2
Macaque
3'-phosphoadenosine 5'-phosphosulfate synthase 2
Mouse
Rat
Horse
3'-phosphoadenosine 5'-phosphosulfate synthase 2
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O95340-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (23)
Biological oxidations (R-HSA-211859)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 14
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Biological oxidations
Reactome
Cytosolic sulfonation of small molecules
Reactome
Defective PAPSS2 causes SEMD-PA
Reactome
Disease
Reactome
Diseases associated with glycosaminoglycan metabolism
Name
Explore in Pharos
Explore in Source
Biological oxidations
Cytosolic sulfonation of small molecules
Defective PAPSS2 causes SEMD-PA
Disease
Diseases associated with glycosaminoglycan metabolism
Gene Ontology Terms (10)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (77)
1 – 10 of 77
PAPSS1
Tbio
Family:  Enzyme
Novelty:  0.01784751
p_int:  0.999999986
p_ni:  1.5e-8
Score:  0.928
Data Source:  BioPlex,STRINGDB
C8B
Tbio
Novelty:  0.00873524
p_int:  0.999989677
p_ni:  0.00001032
p_wrong:  3e-9
Data Source:  BioPlex
WDR6
Tbio
Novelty:  0.20146637
p_int:  0.999988606
p_ni:  0.000011279
p_wrong:  1.15e-7
Score:  0.54
Data Source:  BioPlex,STRINGDB
SPANXB1
Tbio
Novelty:  0.19187624
p_int:  0.99987747
p_ni:  0.00012253
Data Source:  BioPlex
TBX18
Tbio
Family:  TF
Novelty:  0.01287164
p_int:  0.974389559
p_ni:  0.025531269
p_wrong:  0.000079172
Data Source:  BioPlex
SUOX
Tbio
Family:  Enzyme
Novelty:  0.00971136
Score:  0.951
Data Source:  STRINGDB
IMPAD1
Tbio
Family:  Enzyme
Novelty:  0.08211251
Score:  0.946
Data Source:  STRINGDB
BPNT1
Tbio
Family:  Enzyme
Novelty:  0.1114547
Score:  0.944
Data Source:  STRINGDB
CYCS
Tchem
Novelty:  0.00014004
Score:  0.92
Data Source:  STRINGDB
DYM
Tbio
Novelty:  0.02348265
Score:  0.895
Data Source:  STRINGDB
Publication Statistics
PubMed Score  60.41

PubMed score by year
PubTator Score  29.65

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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