Tbio PAPSS2 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2

Protein Summary

Description

Bifunctional enzyme with both ATP sulfurylase and APS kinase activity, which mediates two steps in the sulfate activation pathway. The first step is the transfer of a sulfate group to ATP to yield adenosine 5'-phosphosulfate (APS), and the second step is the transfer of a phosphate group from ATP to APS yielding 3'-phosphoadenylylsulfate (PAPS: activated sulfate donor used by sulfotransferase). In mammals, PAPS is the sole source of sulfate; APS appears to be only an intermediate in the sulfate-activation pathway. May have a important role in skeletogenesis during postnatal growth (By similarity). Sulfation is a common modification of endogenous (lipids, proteins, and carbohydrates) and exogenous (xenobiotics and drugs) compounds. In mammals, the sulfate source is 3'-phosphoadenosine 5'-phosphosulfate (PAPS), created from ATP and inorganic sulfate. Two different tissue isoforms encoded by different genes synthesize PAPS. This gene encodes one of the two PAPS synthetases. Defects in this gene cause the Pakistani type of spondyloepimetaphyseal dysplasia. Two alternatively spliced transcript variants that encode different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• O95340
• Q9BZL2
• Q9P0G6
• Q9UHM1
• Q9UKD3
• Q9UP30
• PAPS synthase 2

Gene Name

• PAPSS2

Ensembl ID

• ENST00000361175
• ENSP00000354436
• ENSG00000198682
• ENST00000456849
• ENSP00000406157

Symbol

• ATPSK2
• SK2
• BCYM4
• ATPSK2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	1
molecular function	0.94
protein domain	0.92
PubMedID	0.86
gene perturbation	0.85

Protein Classes

PANTHER Classes

Protein / Transferase / Nucleotidyltransferase / Bifunctional 3'-phosphoadenosine 5'-phosphosulfate Synthase 2

Protein / Transferase / Kinase / Bifunctional 3'-phosphoadenosine 5'-phosphosulfate Synthase 2

DTO Classes

Protein / Enzyme / Transferase / Nucleotidyltransferase / Bifunctional 3'-phosphoadenosine 5'-phosphosulfate Synthase 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 74.45   (req: < 5)

Gene RIFs: 21   (req: <= 3)

Antibodies: 213   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 74.45   (req: >= 5)

Gene RIFs: 21   (req: > 3)

Antibodies: 213   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0