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Tbio
CELF2
CUGBP Elav-like family member 2

Protein Summary
Description
RNA-binding protein implicated in the regulation of several post-transcriptional events. Involved in pre-mRNA alternative splicing, mRNA translation and stability. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of TNNT2 in embryonic, but not adult, skeletal muscle. Activates TNNT2 exon 5 inclusion by antagonizing the repressive effect of PTB. Acts as both an activator and repressor of a pair of coregulated exons: promotes inclusion of the smooth muscle (SM) exon but exclusion of the non-muscle (NM) exon in actinin pre-mRNAs. Promotes inclusion of exonS 21 and exclusion of exon 5 of the NMDA receptor R1 pre-mRNA. Involved in the apoB RNA editing activity. Increases COX2 mRNA stability and inhibits COX2 mRNA translation in epithelial cells after radiation injury (By similarity). Modulates the cellular apoptosis program by regulating COX2-mediated prostagla ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000399850
  • ENSP00000382743
  • ENSG00000048740
  • ENST00000416382
  • ENSP00000406451
  • ENST00000417956
  • ENSP00000404834
  • ENST00000608830
  • ENSP00000476999
  • ENST00000631460
  • ENSP00000488582
  • ENST00000632728
  • ENSP00000487802
  • ENST00000638035
  • ENSP00000490401

Symbol
  • BRUNOL3
  • CUGBP2
  • ETR3
  • NAPOR
  • ETR3
  • ETR-3
  • NAPOR
  • CELF-2
  • CUGBP2
  • BRUNOL3
  • CUG-BP2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
1
kinase perturbation
0.95
trait
0.93
interacting protein
0.92
disease perturbation
0.79


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 82.87   (req: < 5)
Gene RIFs: 26   (req: <= 3)
Antibodies: 219   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 82.87   (req: >= 5)
Gene RIFs: 26   (req: > 3)
Antibodies: 219   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (77)
1 – 10 of 77
HNRNPC
Tbio
Novelty:  0.00136097
Score:  0.907
Data Source:  STRINGDB
CEBPD
Tbio
Family:  TF
Novelty:  0.00121121
Score:  0.868
Data Source:  STRINGDB
RALY
Tbio
Novelty:  0.03883322
Score:  0.789
Data Source:  STRINGDB
PTGS2
Tclin
Family:  Enzyme
Novelty:  0.00007089
Score:  0.788
Data Source:  STRINGDB
MBNL1
Tbio
Novelty:  0.00441241
Score:  0.784
Data Source:  STRINGDB
MBNL3
Tbio
Novelty:  0.0492081
Score:  0.76
Data Source:  STRINGDB
MBNL2
Tbio
Novelty:  0.02398556
Score:  0.75
Data Source:  STRINGDB
APOBEC1
Tbio
Novelty:  0.00622042
Score:  0.727
Data Source:  STRINGDB
XRN1
Tbio
Family:  Enzyme
Novelty:  0.00409381
Score:  0.721
Data Source:  STRINGDB
RBM24
Tbio
Novelty:  0.04562076
Score:  0.7
Data Source:  STRINGDB
Gene Ontology Terms (10)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
GWAS Traits (19)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
1
2
2
78.7
mathematical ability
2
3
3
74.6
pulse pressure measurement
1
1
1
55.2
wellbeing measurement
3
1
3
52.7
depressive symptom measurement
1
1
1
52.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
2
78.7
mathematical ability
3
74.6
pulse pressure measurement
1
55.2
wellbeing measurement
3
52.7
depressive symptom measurement
1
52.7
Find similar targets by:
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1338822
14007
Rat
RGD:68347
29428
Dog
CUGBP Elav-like family member 2
VGNC:39094
607310
Horse
CUGBP Elav-like family member 2
VGNC:16387
100056973
Xenopus
CUGBP, Elav-like family member 2
XB-GENE-963640
100125022
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
CUGBP Elav-like family member 2
Horse
CUGBP Elav-like family member 2
Xenopus
CUGBP, Elav-like family member 2
Publication Statistics
PubMed Score 82.87
PubMed score by year
PubTator Score 41.10
PubTator score by year