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Tclin
NDUFA10
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial

Protein Classes
Protein Summary
Description
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. The protein encoded by this gene is a component of 42 kDa complex I, the first enzyme complex in the electron transport chain of mitochondria. This protein has NADH dehydrogenase activity and oxidoreductase activity. It transfers electrons from NADH to the respiratory chain. A mutation in this gene was found in an individual with Leigh syndrome. [provided by RefSeq, Apr 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000252711
  • ENSP00000252711
  • ENSG00000130414
  • ENST00000307300
  • ENSP00000302321
  • ENST00000626224
  • ENSP00000487517
  • ENSG00000281434
  • ENST00000630647
  • ENSP00000486639

Symbol
  • CI-42k
  • CI-42KD
  • MC1DN22
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.98
kinase perturbation
0.97
molecular function
0.96
transcription factor perturbation
0.88
histone modification site profile
0.82


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.58   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 175   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.58   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 175   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
metformin
chemical structure image
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sensory perception of smell
1
1
0
6.6
53.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sensory perception of smell
0
6.6
53.3
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
NADH:ubiquinone oxidoreductase subunit A10
VGNC:14320
470696
Macaque
NADH:ubiquinone oxidoreductase subunit A10
697681
Mouse
MGI:1914523
67273
Rat
RGD:727968
678759
Dog
NADH:ubiquinone oxidoreductase subunit A10
608244
Species
Name
OMA
EggNOG
Inparanoid
Chimp
NADH:ubiquinone oxidoreductase subunit A10
Macaque
NADH:ubiquinone oxidoreductase subunit A10
Mouse
Rat
Dog
NADH:ubiquinone oxidoreductase subunit A10
Protein Structure (4 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O95299-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (17)
Complex I biogenesis (R-HSA-6799198)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Complex I biogenesis
Reactome
Metabolism
Reactome
Respiratory electron transport
Reactome
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
Reactome
The citric acid (TCA) cycle and respiratory electron transport
Name
Explore in Pharos
Explore in Source
Complex I biogenesis
Metabolism
Respiratory electron transport
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
The citric acid (TCA) cycle and respiratory electron transport
Gene Ontology Terms (9)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Non-traceable Author Statement (NAS)
UniProtKB
Protein-Protein Interactions (160)
1 – 10 of 160
KDM1B
Tbio
Family: Epigenetic
Novelty: 0.02174039
p_int: 0.999754145
p_ni: 0.000245852
p_wrong: 3e-9
Data Source: BioPlex
ACAD10
Tbio
Family: Enzyme
Novelty: 0.09858243
p_int: 0.999416779
p_ni: 0.000583221
Score: 0.201
Data Source: BioPlex,STRINGDB
MTIF2
Tbio
Novelty: 0.06681774
p_int: 0.996385922
p_ni: 0.003614078
Score: 0.176
Data Source: BioPlex,STRINGDB
NDUFV3
Tclin
Family: Enzyme
Novelty: 0.15352039
p_int: 0.996196635
p_ni: 0.003803365
Score: 0.993
Data Source: BioPlex,STRINGDB
SPATA20
Tdark
Novelty: 0.34126403
p_int: 0.995545715
p_ni: 0.004454285
Score: 0.207
Data Source: BioPlex,STRINGDB
DCX
Tbio
Novelty: 0.00077614
p_int: 0.983344425
p_ni: 0.016655574
p_wrong: 1e-9
Data Source: BioPlex
NDUFB11
Tclin
Family: Enzyme
Novelty: 0.0401232
p_int: 0.979222076
p_ni: 0.020777924
Score: 0.989
Data Source: BioPlex,STRINGDB
NDUFAF7
Tbio
Family: Enzyme
Novelty: 0.24691414
p_int: 0.961658402
p_ni: 0.038328995
p_wrong: 0.000012603
Score: 0.937
Data Source: BioPlex,STRINGDB
DHRS4
Tbio
Family: Enzyme
Novelty: 0.02992279
p_int: 0.940649067
p_ni: 0.058583388
p_wrong: 0.000767544
Score: 0.214
Data Source: BioPlex,STRINGDB
NDUFAF5
Tbio
Family: Enzyme
Novelty: 0.13483499
p_int: 0.911175768
p_ni: 0.013044228
p_wrong: 0.075780004
Score: 0.945
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  13.58

PubMed score by year
PubTator Score  5.84

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer