Tclin NDUFA10 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial

Protein Summary

Description

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. The protein encoded by this gene is a component of 42 kDa complex I, the first enzyme complex in the electron transport chain of mitochondria. This protein has NADH dehydrogenase activity and oxidoreductase activity. It transfers electrons from NADH to the respiratory chain. A mutation in this gene was found in an individual with Leigh syndrome. [provided by RefSeq, Apr 2016]

Uniprot Accession IDs

• O95299
• Q8WXC9

Gene Name

• NDUFA10

Ensembl ID

• ENST00000252711
• ENSP00000252711
• ENSG00000130414
• ENST00000307300
• ENSP00000302321
• ENST00000626224
• ENSP00000487517
• ENSG00000281434
• ENST00000630647
• ENSP00000486639

Symbol

• CI-42k
• CI-42KD
• MC1DN22

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.98
kinase perturbation	0.97
molecular function	0.96
transcription factor perturbation	0.88
histone modification site profile	0.82

Protein Classes

PANTHER Classes

Protein / Transferase / Kinase / Nucleotide Kinase / Nadh Dehydrogenase [Ubiquinone] 1 Alpha Subcomplex Subunit 10, Mitochondrial

DTO Classes

Protein / Enzyme / Transferase / Nadh Dehydrogenase [Ubiquinone] 1 Alpha Subcomplex Subunit 10, Mitochondrial

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.19   (req: < 5)

Gene RIFs: 6   (req: <= 3)

Antibodies: 175   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.19   (req: >= 5)

Gene RIFs: 6   (req: > 3)

Antibodies: 175   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1