You are using an outdated browser. Please upgrade your browser to improve your experience.

Tclin
NDUFC2
NADH dehydrogenase [ubiquinone] 1 subunit C2

Protein Classes
Protein Summary
Description
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000281031
  • ENSP00000281031
  • ENSG00000151366
  • ENST00000525085
  • ENSP00000434262
  • ENST00000527806
  • ENSP00000432739

Symbol
  • HLC-1
  • B14.5b
  • NADHDH2
  • CI-B14.5b
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.95
virus perturbation
0.9
transcription factor perturbation
0.84
gene perturbation
0.83
transcription factor binding site profile
0.78


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.19   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 179   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.19   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 179   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
metformin
chemical structure image
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
NADH dehydrogenase [Source:RefSeq peptide;Acc:NP_001253103]
Mouse
MGI:1344370
68197
Rat
RGD:1307511
293130
Dog
NADH:ubiquinone oxidoreductase subunit C2
476794
Cow
NADH:ubiquinone oxidoreductase subunit C2
338046
Species
Name
OMA
EggNOG
Inparanoid
Macaque
NADH dehydrogenase [Source:RefSeq peptide;Acc:NP_001253103]
Mouse
Rat
Dog
NADH:ubiquinone oxidoreductase subunit C2
Cow
NADH:ubiquinone oxidoreductase subunit C2
Protein Structure (4 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O95298-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (20)
Complex I biogenesis (R-HSA-6799198)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Complex I biogenesis
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Metabolism
Reactome
Neutrophil degranulation
Name
Explore in Pharos
Explore in Source
Complex I biogenesis
Immune System
Innate Immune System
Metabolism
Neutrophil degranulation
Gene Ontology Terms (11)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Non-traceable Author Statement (NAS)
UniProtKB
Protein-Protein Interactions (206)
1 – 10 of 206
NDUFV3
Tclin
Family: Enzyme
Novelty: 0.15352039
p_int: 0.999982823
p_ni: 0.000017177
Score: 0.993
Data Source: BioPlex,STRINGDB
NDUFB11
Tclin
Family: Enzyme
Novelty: 0.0401232
p_int: 0.999978981
p_ni: 0.000021019
Score: 0.998
Data Source: BioPlex,STRINGDB
NDUFA7
Tclin
Family: Enzyme
Novelty: 0.16417588
p_int: 0.999948784
p_ni: 0.000051216
Score: 0.998
Data Source: BioPlex,STRINGDB
NDUFS6
Tclin
Family: Enzyme
Novelty: 0.07910252
p_int: 0.999947446
p_ni: 0.000052554
Score: 0.999
Data Source: BioPlex,STRINGDB
ECSIT
Tbio
Novelty: 0.04690184
p_int: 0.999824203
p_ni: 0.000175796
Score: 0.981
Data Source: BioPlex,STRINGDB
NDUFA9
Tclin
Family: Enzyme
Novelty: 0.00637307
p_int: 0.999600227
p_ni: 0.000399773
Score: 0.997
Data Source: BioPlex,STRINGDB
CHCHD4
Tbio
Novelty: 0.01204944
p_int: 0.999226809
p_ni: 0.00077316
p_wrong: 3.1e-8
Data Source: BioPlex
NDUFB3
Tclin
Family: Enzyme
Novelty: 0.13020753
p_int: 0.998656659
p_ni: 0.001343337
p_wrong: 4e-9
Score: 0.998
Data Source: BioPlex,STRINGDB
NDUFS5
Tclin
Family: Enzyme
Novelty: 0.13274675
p_int: 0.998559077
p_ni: 0.001440923
Score: 0.999
Data Source: BioPlex,STRINGDB
SPPL2B
Tbio
Family: Enzyme
Novelty: 0.0274774
p_int: 0.997526489
p_ni: 0.002473428
p_wrong: 8.3e-8
Data Source: BioPlex
Publication Statistics
PubMed Score  14.19

PubMed score by year
PubTator Score  10.2

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer