MPZL1
Myelin protein zero-like protein 1
Protein Summary
Cell surface receptor, which is involved in signal transduction processes. Recruits PTPN11/SHP-2 to the cell membrane and is a putative substrate of PTPN11/SHP-2. Is a major receptor for concanavalin-A (ConA) and is involved in cellular signaling induced by ConA, which probably includes Src family tyrosine-protein kinases. Isoform 3 seems to have a dominant negative role; it blocks tyrosine phosphorylation of MPZL1 induced by ConA. Isoform 1, but not isoform 2 and isoform 3, may be involved in regulation of integrin-mediated cell motility.
- ENST00000359523
- ENSP00000352513
- ENSG00000197965
- ENST00000392121
- ENSP00000375968
- ENST00000474859
- ENSP00000420455
- PZR
- PZR
- PZRa
- PZRb
- PZR1b
- MPZL1b
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
kinase perturbation | 1 | ||
transcription factor perturbation | 0.97 | ||
disease perturbation | 0.9 | ||
transcription factor binding site profile | 0.85 | ||
virus perturbation | 0.85 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 48.26 (req: < 5)
Gene RIFs: 17 (req: <= 3)
Antibodies: 107 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 48.26 (req: >= 5)
Gene RIFs: 17 (req: > 3)
Antibodies: 107 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 3
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0