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Tbio
SNAPIN
SNARE-associated protein Snapin

Protein Summary
Description
Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking and synaptic vesicle recycling. May modulate a step between vesicle priming, fusion and calcium-dependent neurotransmitter release through its ability to potentiate the interaction of synaptotagmin with the SNAREs and the plasma-membrane-associated protein SNAP25. Its phosphorylation state influences exocytotic protein interactions and may regulate synaptic vesicle exocytosis. May also have a role in the mechanisms of SNARE-mediated membrane fusion in non-neuronal cells (PubMed:17 ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000368685
  • ENSP00000357674
  • ENSG00000143553

Symbol
  • BLOC1S7
  • SNAP25BP
  • SNAPAP
  • BLOS7
  • BORCS3
  • SNAPAP
  • BLOC1S7
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.93
drug perturbation
0.87
interacting protein
0.86
cellular component
0.84
disease perturbation
0.83


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IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 54.26   (req: < 5)
Gene RIFs: 18   (req: <= 3)
Antibodies: 115   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 54.26   (req: >= 5)
Gene RIFs: 18   (req: > 3)
Antibodies: 115   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 25
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
SNAP associated protein
VGNC:6996
738328
Mouse
MGI:1333745
20615
Rat
RGD:1560377
295217
Dog
SNAP associated protein
VGNC:46595
490456
Horse
SNAP associated protein
VGNC:23381
100056434
Species
Name
OMA
EggNOG
Inparanoid
Chimp
SNAP associated protein
Mouse
Rat
Dog
SNAP associated protein
Horse
SNAP associated protein
Pathways (4)
Golgi Associated Vesicle Biogenesis (R-HSA-432722)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Golgi Associated Vesicle Biogenesis
Reactome
Membrane Trafficking
Reactome
Vesicle-mediated transport
Reactome
trans-Golgi Network Vesicle Budding
Name
Explore in Pharos
Explore in Source
Golgi Associated Vesicle Biogenesis
Membrane Trafficking
Vesicle-mediated transport
trans-Golgi Network Vesicle Budding
Gene Ontology Terms (36)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Protein-Protein Interactions (128)
1 – 10 of 128
DTNBP1
Tbio
Novelty: 0.00341619
p_int: 0.999997757
p_ni: 0.000002243
Score: 0.994
Data Source: BioPlex,STRINGDB
BORCS7
Tbio
Novelty: 0.14135922
p_int: 0.999995481
p_ni: 0.000004518
Score: 0.956
Data Source: BioPlex,STRINGDB
CEP170
Tbio
Novelty: 0.05342931
p_int: 0.999977011
p_ni: 0.00002298
p_wrong: 8e-9
Data Source: BioPlex
TRIM69
Tbio
Family: Enzyme
Novelty: 0.18807436
p_int: 0.999973496
p_ni: 0.000026504
Score: 0.542
Data Source: BioPlex,STRINGDB
BORCS6
Tdark
Novelty: 0.83789033
p_int: 0.999961964
p_ni: 0.000036525
p_wrong: 0.000001511
Score: 0.952
Data Source: BioPlex,STRINGDB
BCAS4
Tbio
Novelty: 0.11759439
p_int: 0.999955816
p_ni: 0.000044184
Score: 0.794
Data Source: BioPlex,STRINGDB
BLOC1S6
Tbio
Novelty: 0.01845286
p_int: 0.999844505
p_ni: 0.000155474
p_wrong: 2.1e-8
Score: 0.99
Data Source: BioPlex,STRINGDB
ENTHD1
Tdark
Novelty: 5.29427978
p_int: 0.997814232
p_ni: 0.001826658
p_wrong: 0.000359109
Data Source: BioPlex
EXOC1
Tbio
Novelty: 0.01073858
p_int: 0.997449308
p_ni: 0.002550674
p_wrong: 1.8e-8
Score: 0.248
Data Source: BioPlex,STRINGDB
LAMTOR1
Tbio
Novelty: 0.04952213
p_int: 0.996371667
p_ni: 0.003628163
p_wrong: 1.7e-7
Score: 0.302
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  54.26

PubMed score by year
PubTator Score  30.22

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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