Tbio SNAPIN SNARE-associated protein Snapin

Protein Summary

Description

Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking and synaptic vesicle recycling. May modulate a step between vesicle priming, fusion and calcium-dependent neurotransmitter release through its ability to potentiate the interaction of synaptotagmin with the SNAREs and the plasma-membrane-associated protein SNAP25. Its phosphorylation state influences exocytotic protein interactions and may regulate synaptic vesicle exocytosis. May also have a role in the mechanisms of SNARE-mediated membrane fusion in non-neuronal cells (PubMed:17182842, PubMed:18167355). As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor (PubMed:25898167). The protein encoded by this gene is a coiled-coil-forming protein that associates with the SNARE (soluble N-ethylmaleimide-sensitive fusion protein attachment protein receptor) complex of proteins and the BLOC-1 (biogenesis of lysosome-related organelles) complex. Biochemical studies have identified additional binding partners. As part of the SNARE complex, it is required for vesicle docking and fusion and regulates neurotransmitter release. The BLOC-1 complex is required for the biogenesis of specialized organelles such as melanosomes and platelet dense granules. Mutations in gene products that form the BLOC-1 complex have been identified in mouse strains that are models of Hermansky-Pudlak syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012]

Uniprot Accession IDs

• O95295
• D3DV56
• Q5SXU8

Gene Name

• SNAPIN

Ensembl ID

• ENST00000368685
• ENSP00000357674
• ENSG00000143553

Symbol

• BLOC1S7
• SNAP25BP
• SNAPAP
• BLOS7
• BORCS3
• SNAPAP
• BLOC1S7

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.93
drug perturbation	0.87
interacting protein	0.86
cellular component	0.84
disease perturbation	0.83

Related Tools

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 54.26   (req: < 5)

Gene RIFs: 18   (req: <= 3)

Antibodies: 115   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 54.26   (req: >= 5)

Gene RIFs: 18   (req: > 3)

Antibodies: 115   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 25

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Orthologs (10)

1 – 5 of 10

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	SNAP associated protein	VGNC:6996	738328
Mouse	SNAP-associated protein	MGI:1333745	20615
Rat	SNAP-associated protein	RGD:1560377	295217
Dog	SNAP associated protein	VGNC:46595	490456
Horse	SNAP associated protein	VGNC:23381	100056434

Species	Name	OMA	EggNOG	Inparanoid
Chimp	SNAP associated protein
Mouse	SNAP-associated protein
Rat	SNAP-associated protein
Dog	SNAP associated protein
Horse	SNAP associated protein

Pathways (4)

Reactome (4)

Golgi Associated Vesicle Biogenesis (R-HSA-432722)

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Items per page:

5

1 – 4 of 4

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Golgi Associated Vesicle Biogenesis	56 targets	R-HSA-432722
Reactome	Membrane Trafficking	612 targets	R-HSA-199991
Reactome	Vesicle-mediated transport	725 targets	R-HSA-5653656
Reactome	trans-Golgi Network Vesicle Budding	72 targets	R-HSA-199992

Name	Explore in Pharos	Explore in Source
Golgi Associated Vesicle Biogenesis	56 targets	R-HSA-432722
Membrane Trafficking	612 targets	R-HSA-199991
Vesicle-mediated transport	725 targets	R-HSA-5653656
trans-Golgi Network Vesicle Budding	72 targets	R-HSA-199992

Gene Ontology Terms (36)

Functions (1)

Components (11)

Processes (24)

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Items per page:

10

1 – 1 of 1

GO Term	Evidence	Assigned by
SNARE binding	Inferred from Direct Assay (IDA)	MGI

Protein-Protein Interactions (128)

Explore Interacting Targets

1 – 10 of 128

• See Interactions on String-DB

DTNBP1

Tbio

Novelty: 0.00341619

p_int: 0.999997757

p_ni: 0.000002243

Score: 0.994

Data Source: BioPlex,STRINGDB

BORCS7

Tbio

Novelty: 0.14135922

p_int: 0.999995481

p_ni: 0.000004518

Score: 0.956

Data Source: BioPlex,STRINGDB

CEP170

Tbio

Novelty: 0.05342931

p_int: 0.999977011

p_ni: 0.00002298

p_wrong: 8e-9

Data Source: BioPlex

TRIM69

Tbio

Family: Enzyme

Novelty: 0.18807436

p_int: 0.999973496

p_ni: 0.000026504

Score: 0.542

Data Source: BioPlex,STRINGDB

BORCS6

Tdark

Novelty: 0.83789033

p_int: 0.999961964

p_ni: 0.000036525

p_wrong: 0.000001511

Score: 0.952

Data Source: BioPlex,STRINGDB

BCAS4

Tbio

Novelty: 0.11759439

p_int: 0.999955816

p_ni: 0.000044184

Score: 0.794

Data Source: BioPlex,STRINGDB

BLOC1S6

Tbio

Novelty: 0.01845286

p_int: 0.999844505

p_ni: 0.000155474

p_wrong: 2.1e-8

Score: 0.99

Data Source: BioPlex,STRINGDB

ENTHD1

Tdark

Novelty: 5.29427978

p_int: 0.997814232

p_ni: 0.001826658

p_wrong: 0.000359109

Data Source: BioPlex

EXOC1

Tbio

Novelty: 0.01073858

p_int: 0.997449308

p_ni: 0.002550674

p_wrong: 1.8e-8

Score: 0.248

Data Source: BioPlex,STRINGDB

LAMTOR1

Tbio

Novelty: 0.04952213

p_int: 0.996371667

p_ni: 0.003628163

p_wrong: 1.7e-7

Score: 0.302

Data Source: BioPlex,STRINGDB

Publication Statistics

PubMed Score  54.26

PubMed score by year

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PubTator Score  30.22

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

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UniProt Keyword Find Similar Targets

Acetylation
Cell junction
Coiled coil
Complete proteome
Cytoplasm
Cytoplasmic vesicle
Exocytosis
Golgi apparatus
Host-virus interaction
Lysosome

MGI Phenotype Find Similar Targets

behavior/neurological phenotype
cardiovascular system phenotype
cellular phenotype
endocrine/exocrine gland phenotype
mortality/aging
nervous system phenotype