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Tbio
VAPB
Vesicle-associated membrane protein-associated protein B/C

Protein Summary
Description
Participates in the endoplasmic reticulum unfolded protein response (UPR) by inducing ERN1/IRE1 activity. Involved in cellular calcium homeostasis regulation. The protein encoded by this gene is a type IV membrane protein found in plasma and intracellular vesicle membranes. The encoded protein is found as a homodimer and as a heterodimer with VAPA. This protein also can interact with VAMP1 and VAMP2 and may be involved in vesicle trafficking. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000395802
  • ENSP00000379147
  • ENSG00000124164
  • ENST00000475243
  • ENSP00000417175

Symbol
  • ALS8
  • VAP-B
  • VAMP-B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.93
biological process
0.87
disease perturbation
0.87
kinase perturbation
0.81
microRNA
0.79


Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 210.09   (req: < 5)
Gene RIFs: 59   (req: <= 3)
Antibodies: 301   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 210.09   (req: >= 5)
Gene RIFs: 59   (req: > 3)
Antibodies: 301   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 22
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
VAMP associated protein B and C
VGNC:14146
469984
Mouse
MGI:1928744
56491
Rat
RGD:68326
60431
Dog
VAMP associated protein B and C
VGNC:48230
477274
Horse
VAMP associated protein B and C
VGNC:51622
100056253
Species
Name
OMA
EggNOG
Inparanoid
Chimp
VAMP associated protein B and C
Mouse
Rat
Dog
VAMP associated protein B and C
Horse
VAMP associated protein B and C
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O95292-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (6)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Sphingolipid de novo biosynthesis
Reactome
Sphingolipid metabolism
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of lipids
Sphingolipid de novo biosynthesis
Sphingolipid metabolism
Gene Ontology Terms (28)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Protein-Protein Interactions (211)
1 – 10 of 211
PITPNM2
Tbio
Novelty:  0.0757684
p_int:  1
Score:  0.781
Data Source:  BioPlex,STRINGDB
OSBPL2
Tbio
Novelty:  0.03946704
p_int:  1
Score:  0.569
Data Source:  BioPlex,STRINGDB
VAPA
Tbio
Novelty:  0.00169209
p_int:  0.999999999
p_ni:  1e-9
Score:  0.956
Data Source:  BioPlex,STRINGDB
ACBD5
Tbio
Novelty:  0.10433432
p_int:  0.999999994
p_ni:  3e-9
p_wrong:  3e-9
Score:  0.782
Data Source:  BioPlex,STRINGDB
OSBPL9
Tbio
Novelty:  0.07633459
p_int:  0.999999993
p_ni:  3e-9
p_wrong:  4e-9
Score:  0.85
Data Source:  BioPlex,STRINGDB
RMDN2
Tbio
Novelty:  0.10425524
p_int:  0.999999982
p_ni:  1.8e-8
Score:  0.62
Data Source:  BioPlex,STRINGDB
OSBPL6
Tbio
Novelty:  0.25692861
p_int:  0.999999979
p_ni:  2.1e-8
Score:  0.776
Data Source:  BioPlex,STRINGDB
FAM83G
Tbio
Novelty:  0.13274382
p_int:  0.999999978
p_ni:  8e-9
p_wrong:  1.4e-8
Score:  0.235
Data Source:  BioPlex,STRINGDB
RASSF1
Tbio
Novelty:  0.00137149
p_int:  0.999999976
p_ni:  2e-8
p_wrong:  4e-9
Score:  0.181
Data Source:  BioPlex,STRINGDB
OSBPL10
Tbio
Novelty:  0.11400823
p_int:  0.999999973
p_ni:  8e-9
p_wrong:  1.9e-8
Score:  0.609
Data Source:  BioPlex,STRINGDB
Publication Statistics
PubMed Score  210.09

PubMed score by year
PubTator Score  84.29

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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