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Tbio
VAPB
Vesicle-associated membrane protein-associated protein B/C

Protein Summary
Description
Participates in the endoplasmic reticulum unfolded protein response (UPR) by inducing ERN1/IRE1 activity. Involved in cellular calcium homeostasis regulation. The protein encoded by this gene is a type IV membrane protein found in plasma and intracellular vesicle membranes. The encoded protein is found as a homodimer and as a heterodimer with VAPA. This protein also can interact with VAMP1 and VAMP2 and may be involved in vesicle trafficking. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000395802
  • ENSP00000379147
  • ENSG00000124164
  • ENST00000475243
  • ENSP00000417175

Symbol
  • ALS8
  • VAP-B
  • VAMP-B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.93
biological process
0.87
disease perturbation
0.87
kinase perturbation
0.81
microRNA
0.79


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 181.83   (req: < 5)
Gene RIFs: 59   (req: <= 3)
Antibodies: 301   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 181.83   (req: >= 5)
Gene RIFs: 59   (req: > 3)
Antibodies: 301   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 22
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (6)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Sphingolipid de novo biosynthesis
Reactome
Sphingolipid metabolism
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of lipids
Sphingolipid de novo biosynthesis
Sphingolipid metabolism
Gene Ontology Terms (28)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Protein-Protein Interactions (211)
1 – 10 of 211
PITPNM2
Tbio
Novelty: 0.06360585
p_int: 1
Score: 0.781
Data Source: BioPlex,STRINGDB
OSBPL2
Tbio
Novelty: 0.04469551
p_int: 1
Score: 0.569
Data Source: BioPlex,STRINGDB
VAPA
Tbio
Novelty: 0.0022428
p_int: 0.999999999
p_ni: 1e-9
Score: 0.956
Data Source: BioPlex,STRINGDB
ACBD5
Tbio
Novelty: 0.14084507
p_int: 0.999999994
p_ni: 3e-9
p_wrong: 3e-9
Score: 0.782
Data Source: BioPlex,STRINGDB
OSBPL9
Tbio
Novelty: 0.17213189
p_int: 0.999999993
p_ni: 3e-9
p_wrong: 4e-9
Score: 0.85
Data Source: BioPlex,STRINGDB
RMDN2
Tbio
Novelty: 0.3125
p_int: 0.999999982
p_ni: 1.8e-8
Score: 0.62
Data Source: BioPlex,STRINGDB
OSBPL6
Tbio
Novelty: 0.27710301
p_int: 0.999999979
p_ni: 2.1e-8
Score: 0.776
Data Source: BioPlex,STRINGDB
FAM83G
Tbio
Novelty: 0.08492569
p_int: 0.999999978
p_ni: 8e-9
p_wrong: 1.4e-8
Score: 0.235
Data Source: BioPlex,STRINGDB
RASSF1
Tbio
Novelty: 0.00155893
p_int: 0.999999976
p_ni: 2e-8
p_wrong: 4e-9
Score: 0.181
Data Source: BioPlex,STRINGDB
OSBPL10
Tbio
Novelty: 0.17310413
p_int: 0.999999973
p_ni: 8e-9
p_wrong: 1.9e-8
Score: 0.609
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  181.83

PubMed score by year
PubTator Score  84.29

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer