Tbio VAPB Vesicle-associated membrane protein-associated protein B/C

Protein Summary

Description

Participates in the endoplasmic reticulum unfolded protein response (UPR) by inducing ERN1/IRE1 activity. Involved in cellular calcium homeostasis regulation. The protein encoded by this gene is a type IV membrane protein found in plasma and intracellular vesicle membranes. The encoded protein is found as a homodimer and as a heterodimer with VAPA. This protein also can interact with VAMP1 and VAMP2 and may be involved in vesicle trafficking. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• O95292
• A2A2F2
• O95293
• Q9P0H0
• VAMP-B/VAMP-C

Gene Name

• VAPB

Ensembl ID

• ENST00000395802
• ENSP00000379147
• ENSG00000124164
• ENST00000475243
• ENSP00000417175

Symbol

• ALS8
• VAP-B
• VAMP-B

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	0.93
biological process	0.87
disease perturbation	0.87
kinase perturbation	0.81
microRNA	0.79

Protein Classes

PANTHER Classes

Protein / Membrane Traffic Protein / Membrane Trafficking Regulatory Protein / Vesicle-associated Membrane Protein-associated Protein B/c

DTO Classes

Protein / Transporter / Membrane Trafficking Regulatory Protein / Vesicle-associated Membrane Protein-associated Protein B/c

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 247.25   (req: < 5)

Gene RIFs: 77   (req: <= 3)

Antibodies: 301   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 247.25   (req: >= 5)

Gene RIFs: 77   (req: > 3)

Antibodies: 301   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 22

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0