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Tchem
KCNK5
Potassium channel subfamily K member 5

Protein Summary
Description
pH-dependent, voltage insensitive, outwardly rectifying potassium channel. Outward rectification is lost at high external K(+) concentrations. This gene encodes one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. The message for this gene is mainly expressed in the cortical distal tubules and collecting ducts of the kidney. The protein is highly sensitive to external pH and this, in combination with its expression pattern, suggests it may play an important role in renal potassium transport. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000359534
  • ENSP00000352527
  • ENSG00000164626

Symbol
  • TASK2
  • TASK2
  • K2p5.1
  • KCNK5b
  • TASK-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.88
molecular function
0.79
virus perturbation
0.79
PubMedID
0.73
transcription factor binding site profile
0.66


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 112.8   (req: < 5)
Gene RIFs: 17   (req: <= 3)
Antibodies: 90   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 112.8   (req: >= 5)
Gene RIFs: 17   (req: > 3)
Antibodies: 90   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
halothane
chemical structure image
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
2
4
61.3
1
1
0
1.1
60.2
intraocular pressure measurement
1
1
1
46
mean corpuscular hemoglobin concentration
1
1
1
41.8
apolipoprotein B measurement
1
1
1
3.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
4
61.3
0
1.1
60.2
intraocular pressure measurement
1
46
mean corpuscular hemoglobin concentration
1
41.8
apolipoprotein B measurement
1
3.8
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
potassium two pore domain channel subfamily K member 5
VGNC:7899
462666
Macaque
potassium two pore domain channel subfamily K member 5
719563
Mouse
MGI:1336175
16529
Rat
RGD:1564985
364241
Dog
potassium two pore domain channel subfamily K member 5
VGNC:42277
481780
Species
Name
OMA
EggNOG
Inparanoid
Chimp
potassium two pore domain channel subfamily K member 5
Macaque
potassium two pore domain channel subfamily K member 5
Mouse
Rat
Dog
potassium two pore domain channel subfamily K member 5
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-O95279-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (5)
Cardiac conduction (R-HSA-5576891)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cardiac conduction
Reactome
Muscle contraction
Reactome
Phase 4 - resting membrane potential
Name
Explore in Pharos
Explore in Source
Cardiac conduction
Muscle contraction
Phase 4 - resting membrane potential
Protein-Protein Interactions (36)
1 – 10 of 36
KCNN4
Tchem
Family: IC
Novelty: 0.00244935
Score: 0.905
Data Source: STRINGDB
KCNQ1
Tclin
Family: IC
Novelty: 0.0008956
Score: 0.89
Data Source: STRINGDB
KCNJ13
Tchem
Family: IC
Novelty: 0.01636495
Score: 0.837
Data Source: STRINGDB
HCN4
Tclin
Family: IC
Novelty: 0.0021957
Score: 0.831
Data Source: STRINGDB
CACNA1C
Tclin
Family: IC
Novelty: 0.00099998
Score: 0.818
Data Source: STRINGDB
KCNE3
Tbio
Family: IC
Novelty: 0.01541806
Score: 0.817
Data Source: STRINGDB
CACNA1A
Tchem
Family: IC
Novelty: 0.00069217
Score: 0.815
Data Source: STRINGDB
SCN2A
Tclin
Family: IC
Novelty: 0.0007317
Score: 0.813
Data Source: STRINGDB
CNNM2
Tbio
Novelty: 0.03252541
Score: 0.662
Data Source: STRINGDB
MIA3
Tbio
Novelty: 0.02784348
Score: 0.662
Data Source: STRINGDB
Publication Statistics
PubMed Score  112.80

PubMed score by year
PubTator Score  255.23

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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