KCNK5
Potassium channel subfamily K member 5
Protein Summary
pH-dependent, voltage insensitive, outwardly rectifying potassium channel. Outward rectification is lost at high external K(+) concentrations. This gene encodes one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. The message for this gene is mainly expressed in the cortical distal tubules and collecting ducts of the kidney. The protein is highly sensitive to external pH and this, in combination with its expression pattern, suggests it may play an important role in renal potassium transport. [provided by RefSeq, Jul 2008]
- ENST00000359534
- ENSP00000352527
- ENSG00000164626
- TASK2
- TASK2
- K2p5.1
- KCNK5b
- TASK-2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
transcription factor perturbation | 0.88 | ||
molecular function | 0.79 | ||
virus perturbation | 0.79 | ||
PubMedID | 0.73 | ||
transcription factor binding site profile | 0.66 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 133.02 (req: < 5)
Gene RIFs: 18 (req: <= 3)
Antibodies: 90 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 133.02 (req: >= 5)
Gene RIFs: 18 (req: > 3)
Antibodies: 90 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 7
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 1
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 1