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Tbio
O95278
Laforin

Protein Summary
Description
Plays an important role in preventing glycogen hyperphosphorylation and the formation of insoluble aggregates, via its activity as glycogen phosphatase, and by promoting the ubiquitination of proteins involved in glycogen metabolism via its interaction with the E3 ubiquitin ligase NHLRC1/malin. Shows strong phosphatase activity towards complex carbohydrates in vitro, avoiding glycogen hyperphosphorylation which is associated with reduced branching and formation of insoluble aggregates (PubMed:16901901, PubMed:23922729, PubMed:26231210, PubMed:25538239, PubMed:25544560). Dephosphorylates phosphotyrosine and synthetic substrates, such as para-nitrophenylphosphate (pNPP), and has low activity with phosphoserine and phosphothreonine substrates (in vitro) (PubMed:11001928, PubMed:11220751, PubMed:11739371, PubMed:14532330, PubMed:16971387, PubMed:18617530, PubMed:22036712, PubMed:23922729, PubMed:14722920). Has been shown to dephosphorylate MAPT (By similarity). Forms a complex with NHLRC1/ ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000367519
  • ENSP00000356489
  • ENSG00000112425
  • ENST00000435470
  • ENSP00000405913
  • ENST00000611340
  • ENSP00000480268
  • ENST00000618445
  • ENSP00000480339
  • ENST00000638262
  • ENSP00000492876
  • ENST00000638778
  • ENSP00000491353
  • ENST00000638783
  • ENSP00000491338
  • ENST00000639423
  • ENSP00000492701
  • ENST00000639465
  • ENSP00000491180

Symbol
  • EPM2
  • MELF
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.99
histone modification site profile
0.88
transcription factor binding site profile
0.75
microRNA
0.73
cellular component
0.69


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 284.64   (req: < 5)
Gene RIFs: 49   (req: <= 3)
Antibodies: 507   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 284.64   (req: >= 5)
Gene RIFs: 49   (req: > 3)
Antibodies: 507   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 22
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0