Protein Summary
Plays an important role in preventing glycogen hyperphosphorylation and the formation of insoluble aggregates, via its activity as glycogen phosphatase, and by promoting the ubiquitination of proteins involved in glycogen metabolism via its interaction with the E3 ubiquitin ligase NHLRC1/malin. Shows strong phosphatase activity towards complex carbohydrates in vitro, avoiding glycogen hyperphosphorylation which is associated with reduced branching and formation of insoluble aggregates (PubMed:16901901, PubMed:23922729, PubMed:26231210, PubMed:25538239, PubMed:25544560). Dephosphorylates phosphotyrosine and synthetic substrates, such as para-nitrophenylphosphate (pNPP), and has low activity with phosphoserine and phosphothreonine substrates (in vitro) (PubMed:11001928, PubMed:11220751, PubMed:11739371, PubMed:14532330, PubMed:16971387, PubMed:18617530, PubMed:22036712, PubMed:23922729, PubMed:14722920). Has been shown to dephosphorylate MAPT (By similarity). Forms a complex with NHLRC1/ ...more
- ENST00000367519
- ENSP00000356489
- ENSG00000112425
- ENST00000435470
- ENSP00000405913
- ENST00000611340
- ENSP00000480268
- ENST00000618445
- ENSP00000480339
- ENST00000638262
- ENSP00000492876
- ENST00000638778
- ENSP00000491353
- ENST00000638783
- ENSP00000491338
- ENST00000639423
- ENSP00000492701
- ENST00000639465
- ENSP00000491180
- EPM2
- MELF
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
protein domain | 0.99 | ||
histone modification site profile | 0.88 | ||
transcription factor binding site profile | 0.75 | ||
microRNA | 0.73 | ||
cellular component | 0.69 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 232.01 (req: < 5)
Gene RIFs: 49 (req: <= 3)
Antibodies: 507 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 232.01 (req: >= 5)
Gene RIFs: 49 (req: > 3)
Antibodies: 507 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 22
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (83)
STBD1
Novelty: 0.08362185
p_int: 0.999999857
p_ni: 1.2e-8
p_wrong: 1.31e-7
Score: 0.917
Data Source: BioPlex,STRINGDB
PRKAB2
Family: Enzyme
Novelty: 0.02815065
p_int: 0.922313627
p_ni: 0.000001019
p_wrong: 0.077685354
Score: 0.844
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (9)
Reactome (9)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Disease | ||||
Reactome | Diseases of carbohydrate metabolism | ||||
Reactome | Diseases of metabolism | ||||
Reactome | Glycogen metabolism | ||||
Reactome | Glycogen storage diseases | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Disease | ||||
Diseases of carbohydrate metabolism | ||||
Diseases of metabolism | ||||
Glycogen metabolism | ||||
Glycogen storage diseases | ||||
Viral Interactions (0)
Gene Ontology Terms (28)
Functions (10)
Components (6)
Processes (12)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations ()
GWAS Traits (2)
Items per page:
1 – 2 of 2
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
mean platelet volume | 3 | 2 | 3 | 86.1 | |||||
self reported educational attainment | 1 | 1 | 1 | 9.4 | |||||
Items per page:
1 – 2 of 2
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
mean platelet volume | 3 | 86.1 | |||||
self reported educational attainment | 1 | 9.4 | |||||
Find similar targets by:
IDG Resources
Orthologs (10)
1 – 5 of 10
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | EPM2A, laforin glucan phosphatase | VGNC:14789 | 748434 | |||||
Mouse | MGI:1341085 | 13853 | ||||||
Rat | RGD:71047 | 114005 | ||||||
Dog | EPM2A, laforin glucan phosphatase | VGNC:53700 | 484022 | |||||
Cow | EPM2A, laforin glucan phosphatase | VGNC:53790 | 526888 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | EPM2A, laforin glucan phosphatase | |||||
Mouse | ||||||
Rat | ||||||
Dog | EPM2A, laforin glucan phosphatase | |||||
Cow | EPM2A, laforin glucan phosphatase | |||||
Publication Statistics
PubMed Score 232.01
PubMed score by year
PubTator Score 139.88
PubTator score by year
Related Publications
Text Mined References (76)
GeneRif Annotations (49)
Items per page:
0 of 0
PMID | Year | Title |
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