Tbio CCNDBP1 Cyclin-D1-binding protein 1

Protein Summary

Description

May negatively regulate cell cycle progression. May act at least in part via inhibition of the cyclin-D1/CDK4 complex, thereby preventing phosphorylation of RB1 and blocking E2F-dependent transcription. This gene was identified by the interaction of its gene product with Grap2, a leukocyte-specific adaptor protein important for immune cell signaling. The protein encoded by this gene was shown to interact with cyclin D. Transfection of this gene in cells was reported to reduce the phosphorylation of Rb gene product by cyclin D-dependent protein kinase, and inhibit E2F1-mediated transcription activity. This protein was also found to interact with helix-loop-helix protein E12 and is thought to be a negative regulator of liver-specific gene expression. Several alternatively spliced variants have been found for this gene. [provided by RefSeq, Apr 2009]

Uniprot Accession IDs

• O95273
• A8K3Q0
• A8K3U2
• Q6ZQN9
• Q7Z519
• Q8NBS7
• Q8NBY2
• Q9NS19
• Q9NYH3
• Q9UHX9

Gene Name

• CCNDBP1

Ensembl ID

• ENST00000300213
• ENSP00000300213
• ENSG00000166946
• ENST00000565296
• ENSP00000455419
• ENST00000566515
• ENSP00000456797

Symbol

• DIP1
• GCIP
• HHM
• HHM
• DIP1
• GCIP

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.99
kinase perturbation	0.97
virus perturbation	0.88
cell type or tissue	0.84
histone modification site profile	0.65

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 102.46   (req: < 5)

Gene RIFs: 14   (req: <= 3)

Antibodies: 232   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 102.46   (req: >= 5)

Gene RIFs: 14   (req: > 3)

Antibodies: 232   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0