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Tchem
TNKS
Tankyrase-1

Protein Summary
Description
Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation (PARsylation) of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates PARsylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination. Mediates PARsylation of TERF1, thereby contributing to the regulation of telomere length. Involved in centrosome maturation during prometaphase by mediating PARsylation of HEPACAM2/MIKI. May also regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles. May be involved in spindle pole assembly through PARsylation of NUMA1. Stimulates 26S proteasome activity.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000310430
  • ENSP00000311579
  • ENSG00000173273

Symbol
  • PARP5A
  • PARPL
  • TIN1
  • TINF1
  • TNKS1
  • TIN1
  • ARTD5
  • PARPL
  • TINF1
  • TNKS1
  • pART5
  • PARP5A
  • PARP-5a
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.92
protein domain
0.92
cellular component
0.82
disease perturbation
0.79
transcription factor binding site profile
0.77


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 263.6   (req: < 5)
Gene RIFs: 60   (req: <= 3)
Antibodies: 343   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 263.6   (req: >= 5)
Gene RIFs: 60   (req: > 3)
Antibodies: 343   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 26
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 418
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3
Approved Drugs (3)
1 – 3 of 3
rucaparib
chemical structure image
olaparib
chemical structure image
niraparib
chemical structure image
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
1
2
2
83.8
mathematical ability
3
3
3
80
smoking behaviour measurement
1
1
1
73
wellbeing measurement
2
2
2
70.1
risk-taking behaviour
1
2
2
30.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
83.8
mathematical ability
3
80
smoking behaviour measurement
1
73
wellbeing measurement
2
70.1
risk-taking behaviour
2
30.7
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
tankyrase
VGNC:10224
463982
Macaque
tankyrase
699004
Mouse
MGI:1341087
21951
Rat
RGD:1308784
290794
Dog
tankyrase
VGNC:47681
475603
Species
Name
OMA
EggNOG
Inparanoid
Chimp
tankyrase
Macaque
tankyrase
Mouse
Rat
Dog
tankyrase
Protein Structure (33 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O95271-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 33
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (19)
Degradation of AXIN (R-HSA-4641257)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 16
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Degradation of AXIN
Reactome
Deubiquitination
Reactome
Disease
Reactome
Diseases of signal transduction
Reactome
Intracellular signaling by second messengers
Name
Explore in Pharos
Explore in Source
Degradation of AXIN
Deubiquitination
Disease
Diseases of signal transduction
Intracellular signaling by second messengers
Gene Ontology Terms (40)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Protein-Protein Interactions (180)
1 – 10 of 180
PAGE4
Tbio
Novelty: 0.05404149
p_int: 0.999999913
p_ni: 8.7e-8
Data Source: BioPlex
BABAM1
Tbio
Novelty: 0.03812501
p_int: 0.999999647
p_ni: 3.53e-7
Score: 0.565
Data Source: BioPlex,STRINGDB
FAM117B
Tdark
Novelty: 1.06316483
p_int: 0.999999596
p_ni: 4.04e-7
Data Source: BioPlex
SSSCA1
Tdark
Novelty: 0.53523038
p_int: 0.999997767
p_ni: 0.000002233
Data Source: BioPlex
HIF1AN
Tbio
Novelty: 0.00861018
p_int: 0.999996795
p_ni: 0.000003205
Score: 0.563
Data Source: BioPlex,STRINGDB
SH3BP5L
Tdark
Novelty: 1.7921497
p_int: 0.999996488
p_ni: 0.000003512
Data Source: BioPlex
GMDS
Tbio
Family: Enzyme
Novelty: 0.00622275
p_int: 0.999991377
p_ni: 0.000008623
Score: 0.922
Data Source: BioPlex,STRINGDB
RNF166
Tdark
Novelty: 0.71460884
p_int: 0.999990241
p_ni: 0.000009759
Data Source: BioPlex
PPP1R12B
Tbio
Family: Enzyme
Novelty: 0.0424259
p_int: 0.999883854
p_ni: 0.000116146
Data Source: BioPlex
EPN3
Tbio
Novelty: 0.12685855
p_int: 0.999726731
p_ni: 0.000273269
Score: 0.164
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  263.60

PubMed score by year
PubTator Score  674.77

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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