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Tchem
TNKS
Tankyrase-1

Protein Summary
Description
Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation (PARsylation) of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates PARsylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination. Mediates PARsylation of TERF1, thereby contributing to the regulation of telomere length. Involved in centrosome maturation during prometaphase by mediating PARsylation of HEPACAM2/MIKI. May also regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles. May be involved in spindle pole assembly through PARsylation of NUMA1. Stimulates 26S proteasome activity.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000310430
  • ENSP00000311579
  • ENSG00000173273

Symbol
  • PARP5A
  • PARPL
  • TIN1
  • TINF1
  • TNKS1
  • TIN1
  • ARTD5
  • PARPL
  • TINF1
  • TNKS1
  • pART5
  • PARP5A
  • PARP-5a
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.92
protein domain
0.92
cellular component
0.82
disease perturbation
0.79
transcription factor binding site profile
0.77


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 219.66   (req: < 5)
Gene RIFs: 60   (req: <= 3)
Antibodies: 343   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 219.66   (req: >= 5)
Gene RIFs: 60   (req: > 3)
Antibodies: 343   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 26
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 418
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3
Protein Data Bank (33)
1 – 5 of 33
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (19)
Degradation of AXIN (R-HSA-4641257)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 16
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Degradation of AXIN
Reactome
Deubiquitination
Reactome
Disease
Reactome
Diseases of signal transduction
Reactome
Intracellular signaling by second messengers
Name
Explore in Pharos
Explore in Source
Degradation of AXIN
Deubiquitination
Disease
Diseases of signal transduction
Intracellular signaling by second messengers
Gene Ontology Terms (40)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Protein-Protein Interactions (180)
1 – 10 of 180
PAGE4
Tbio
Novelty: 0.05393722
p_int: 0.999999913
p_ni: 8.7e-8
Data Source: BioPlex
BABAM1
Tbio
Novelty: 0.05690582
p_int: 0.999999647
p_ni: 3.53e-7
Score: 0.565
Data Source: BioPlex,STRINGDB
FAM117B
Tdark
Novelty: 10.56140351
p_int: 0.999999596
p_ni: 4.04e-7
Data Source: BioPlex
SSSCA1
Tdark
Novelty: 0.8
p_int: 0.999997767
p_ni: 0.000002233
Data Source: BioPlex
HIF1AN
Tbio
Novelty: 0.01079184
p_int: 0.999996795
p_ni: 0.000003205
Score: 0.563
Data Source: BioPlex,STRINGDB
SH3BP5L
Tdark
Novelty: 4
p_int: 0.999996488
p_ni: 0.000003512
Data Source: BioPlex
GMDS
Tbio
Family: Enzyme
Novelty: 0.00474944
p_int: 0.999991377
p_ni: 0.000008623
Score: 0.922
Data Source: BioPlex,STRINGDB
RNF166
Tdark
Novelty: 0.66985646
p_int: 0.999990241
p_ni: 0.000009759
Data Source: BioPlex
PPP1R12B
Tbio
Family: Enzyme
Novelty: 0.06135268
p_int: 0.999883854
p_ni: 0.000116146
Data Source: BioPlex
EPN3
Tbio
Novelty: 0.14281801
p_int: 0.999726731
p_ni: 0.000273269
Score: 0.164
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  219.66

PubMed score by year
PubTator Score  674.77

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer