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Tchem
RASGRP1
RAS guanyl-releasing protein 1

Protein Summary
Description
Functions as a calcium- and diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP (PubMed:15899849, PubMed:23908768). Activates the Erk/MAP kinase cascade (PubMed:15899849). Regulates T-cell/B-cell development, homeostasis and differentiation by coupling T-lymphocyte/B-lymphocyte antigen receptors to Ras (PubMed:10807788, PubMed:12839994). Regulates NK cell cytotoxicity and ITAM-dependent cytokine production by activation of Ras-mediated ERK and JNK pathways (PubMed:19933860). Functions in mast cell degranulation and cytokine secretion, regulating FcERI-evoked allergic responses (By similarity). May also function in differentiation of other cell types (PubMed:12845332). This gene is a member of a family of genes characterized by the presence of a Ras superfamily guanine nucleotide exchange factor (GEF) domain. It functions as a diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000310803
  • ENSP00000310244
  • ENSG00000172575
  • ENST00000414708
  • ENSP00000413105
  • ENST00000450598
  • ENSP00000388540
  • ENST00000558164
  • ENSP00000454164
  • ENST00000559830
  • ENSP00000452721

Symbol
  • RASGRP
  • RASGRP
  • CALDAG-GEFI
  • CALDAG-GEFII
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
1
protein domain
0.99
PubMedID
0.93
transcription factor perturbation
0.91
biological process
0.85


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 122.59   (req: < 5)
Gene RIFs: 32   (req: <= 3)
Antibodies: 140   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 122.59   (req: >= 5)
Gene RIFs: 32   (req: > 3)
Antibodies: 140   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 35
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 5
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (182)
Activation of RAS in B cells (R-HSA-1169092)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 26
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of RAS in B cells
Reactome
Adaptive Immune System
Reactome
Cytokine Signaling in Immune system
Reactome
Downstream signaling events of B Cell Receptor (BCR)
Reactome
Effects of PIP2 hydrolysis
Name
Explore in Pharos
Explore in Source
Activation of RAS in B cells
Adaptive Immune System
Cytokine Signaling in Immune system
Downstream signaling events of B Cell Receptor (BCR)
Effects of PIP2 hydrolysis
Gene Ontology Terms (42)
Items per page:
10
1 – 10 of 10
GO Term
Evidence
Assigned by
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (119)
1 – 10 of 119
HRAS
Tchem
Family: Enzyme
Novelty: 0.00008788
Score: 0.987
Data Source: Reactome,STRINGDB
RAP1B
Tbio
Family: Enzyme
Novelty: 0.00195699
Score: 0.963
Data Source: Reactome,STRINGDB
KRAS
Tchem
Family: Enzyme
Novelty: 0.00018907
Score: 0.961
Data Source: Reactome,STRINGDB
NRAS
Tchem
Family: Enzyme
Novelty: 0.00085585
Score: 0.957
Data Source: Reactome,STRINGDB
RAP1A
Tchem
Family: Enzyme
Novelty: 0.00466391
Score: 0.956
Data Source: Reactome,STRINGDB
RRAS
Tbio
Family: Enzyme
Novelty: 0.00229703
Score: 0.952
Data Source: STRINGDB
ITPR1
Tchem
Family: IC
Novelty: 0.00160922
Score: 0.923
Data Source: STRINGDB
ITPR3
Tchem
Family: IC
Novelty: 0.00274855
Score: 0.921
Data Source: STRINGDB
PRKCQ
Tchem
Family: Kinase
Novelty: 0.00583392
Score: 0.918
Data Source: STRINGDB
RASGRP2
Tbio
Novelty: 0.0268775
Score: 0.908
Data Source: STRINGDB
Publication Statistics
PubMed Score  122.59

PubMed score by year
PubTator Score  70.58

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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