You are using an outdated browser. Please upgrade your browser to improve your experience.

Tchem
HTR3B
5-hydroxytryptamine receptor 3B

Protein Classes
Protein Summary
Description
This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses. It is a cation-specific, but otherwise relatively nonselective, ion channel. The product of this gene belongs to the ligand-gated ion channel receptor superfamily. This gene encodes subunit B of the type 3 receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor causes fast, depolarizing responses in neurons after activation. It is not functional as a homomeric complex, but a pentaheteromeric complex with subunit A (HTR3A) displays the full functional features of this receptor. [provided by RefSeq, Aug 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000260191
  • ENSP00000260191
  • ENSG00000149305
  • ENST00000537778
  • ENSP00000443118

Symbol
  • 5-HT3B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.86
protein domain
0.85
gene perturbation
0.62
phenotype
0.59
disease
0.57


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 67.13   (req: < 5)
Gene RIFs: 49   (req: <= 3)
Antibodies: 160   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 67.13   (req: >= 5)
Gene RIFs: 49   (req: > 3)
Antibodies: 160   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 6
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
prostate carcinoma
2
1
0
1.1
76.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
prostate carcinoma
0
1.1
76.3
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
5-hydroxytryptamine receptor 3B
VGNC:7502
466788
Macaque
5-hydroxytryptamine receptor 3B
694830
Mouse
MGI:1861899
57014
Rat
RGD:61820
58963
Dog
5-hydroxytryptamine receptor 3B
VGNC:41830
611236
Species
Name
OMA
EggNOG
Inparanoid
Chimp
5-hydroxytryptamine receptor 3B
Macaque
5-hydroxytryptamine receptor 3B
Mouse
Rat
Dog
5-hydroxytryptamine receptor 3B
Pathways (5)
Neuronal System (R-HSA-112316)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Neuronal System
Reactome
Neurotransmitter receptors and postsynaptic signal transmission
Reactome
Transmission across Chemical Synapses
Name
Explore in Pharos
Explore in Source
Neuronal System
Neurotransmitter receptors and postsynaptic signal transmission
Transmission across Chemical Synapses
Protein-Protein Interactions (72)
1 – 10 of 72
HTR3A
Tclin
Family: IC
Novelty: 0.00217443
Score: 0.941
Data Source: Reactome,STRINGDB
HTR1E
Tchem
Family: GPCR
Novelty: 0.02160816
Score: 0.743
Data Source: STRINGDB
GRIN3A
Tclin
Family: IC
Novelty: 0.00877072
Score: 0.741
Data Source: STRINGDB
HTR5A
Tchem
Family: GPCR
Novelty: 0.0160551
Score: 0.737
Data Source: STRINGDB
GRIN2C
Tclin
Family: IC
Novelty: 0.00430771
Score: 0.692
Data Source: STRINGDB
HTR7
Tclin
Family: GPCR
Novelty: 0.00169884
Score: 0.671
Data Source: STRINGDB
HTR1B
Tclin
Family: GPCR
Novelty: 0.00073663
Score: 0.665
Data Source: STRINGDB
GRIA4
Tclin
Family: IC
Novelty: 0.00284417
Score: 0.664
Data Source: STRINGDB
GRIN3B
Tclin
Family: IC
Novelty: 0.02261519
Score: 0.656
Data Source: STRINGDB
ATP6AP1
Tchem
Family: Enzyme
Novelty: 0.00583201
Score: 0.654
Data Source: STRINGDB
Publication Statistics
PubMed Score  67.13

PubMed score by year
PubTator Score  53.06

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: