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Tclin
PDE8B
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B

Protein Summary
Description
Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in specific signaling in the thyroid gland. The protein encoded by this gene is a cyclic nucleotide phosphodiesterase (PDE) that catalyzes the hydrolysis of the second messenger cAMP. The encoded protein, which does not hydrolyze cGMP, is resistant to several PDE inhibitors. Defects in this gene are a cause of autosomal dominant striatal degeneration (ADSD). Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000264917
  • ENSP00000264917
  • ENSG00000113231
  • ENST00000333194
  • ENSP00000331336
  • ENST00000340978
  • ENSP00000345446
  • ENST00000342343
  • ENSP00000345646
  • ENST00000346042
  • ENSP00000330428
  • ENST00000505283
  • ENSP00000423461

Symbol
  • ADSD
  • PPNAD3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.92
biological process
0.87
disease perturbation
0.83
transcription factor perturbation
0.68
histone modification site profile
0.64


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.45   (req: < 5)
Gene RIFs: 22   (req: <= 3)
Antibodies: 146   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.45   (req: >= 5)
Gene RIFs: 22   (req: > 3)
Antibodies: 146   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 115
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
thyroid function
2
2
2
98.3
thyroid stimulating hormone measurement
2
2
2
93.1
2
2
1
1.1
88.5
hormone measurement
1
1
3
87.1
1
1
1
80.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
thyroid function
2
98.3
thyroid stimulating hormone measurement
2
93.1
1
1.1
88.5
hormone measurement
3
87.1
1
80.3
Orthologs (2)
1 – 2 of 2
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
phosphodiesterase 8B
VGNC:4125
461796
Macaque
phosphodiesterase 8B
712674
Species
Name
OMA
EggNOG
Inparanoid
Chimp
phosphodiesterase 8B
Macaque
phosphodiesterase 8B
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-O95263-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (79)
G alpha (s) signalling events (R-HSA-418555)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
G alpha (s) signalling events
Reactome
GPCR downstream signalling
Reactome
Signal Transduction
Reactome
Signaling by GPCR
Name
Explore in Pharos
Explore in Source
G alpha (s) signalling events
GPCR downstream signalling
Signal Transduction
Signaling by GPCR
Gene Ontology Terms (5)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (83)
1 – 10 of 83
APRT
Tbio
Family: Enzyme
Novelty: 0.00483077
Score: 0.922
Data Source: STRINGDB
ADK
Tchem
Family: Kinase
Novelty: 0.00196435
Score: 0.911
Data Source: STRINGDB
ADSL
Tbio
Family: Enzyme
Novelty: 0.0028496
Score: 0.91
Data Source: STRINGDB
AK3
Tbio
Family: Kinase
Novelty: 0.02673466
Score: 0.903
Data Source: STRINGDB
DCK
Tchem
Family: Kinase
Novelty: 0.00201831
Score: 0.902
Data Source: STRINGDB
PDE8A
Tclin
Family: Enzyme
Novelty: 0.04254335
Score: 0.804
Data Source: STRINGDB
ADCY9
Tbio
Family: Enzyme
Novelty: 0.00744116
Score: 0.759
Data Source: STRINGDB
AMPD3
Tchem
Family: Enzyme
Novelty: 0.01230806
Score: 0.757
Data Source: STRINGDB
AMPD2
Tchem
Family: Enzyme
Novelty: 0.01510718
Score: 0.747
Data Source: STRINGDB
AK2
Tbio
Family: Kinase
Novelty: 0.00581034
Score: 0.732
Data Source: STRINGDB
Publication Statistics
PubMed Score  36.45

PubMed score by year
PubTator Score  36.62

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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