You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
ATE1
Arginyl-tRNA--protein transferase 1

Protein Summary
Description
Involved in the post-translational conjugation of arginine to the N-terminal aspartate or glutamate of a protein. This arginylation is required for degradation of the protein via the ubiquitin pathway. Does not arginylate cysteine residues (By similarity). This gene encodes an arginyltransferase, an enzyme that is involved in posttranslational conjugation of arginine to N-terminal aspartate or glutamate residues. Conjugation of arginine to the N-terminal aspartate or glutamate targets proteins for ubiquitin-dependent degradation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000224652
  • ENSP00000224652
  • ENSG00000107669
  • ENST00000369043
  • ENSP00000358039
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.9
transcription factor perturbation
0.8
transcription factor binding site profile
0.76
tissue sample
0.67
kinase perturbation
0.66


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 70.65   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 166   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 70.65   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 166   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
3
4
6
88.3
1
2
0
1.1
42
BMI-adjusted hip circumference
1
1
1
4.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
6
88.3
0
1.1
42
BMI-adjusted hip circumference
1
4.5
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
arginyltransferase 1
VGNC:51966
450786
Macaque
arginyltransferase 1
705248
Mouse
MGI:1333870
11907
Rat
RGD:1309335
293526
Dog
arginyltransferase 1
VGNC:38206
486919
Species
Name
OMA
EggNOG
Inparanoid
Chimp
arginyltransferase 1
Macaque
arginyltransferase 1
Mouse
Rat
Dog
arginyltransferase 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-O95260-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (5)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (68)
1 – 10 of 68
REG4
Tbio
Novelty:  0.01123311
p_int:  0.999969267
p_ni:  0.000030733
Score:  0.175
Data Source:  BioPlex,STRINGDB
ARL2BP
Tbio
Novelty:  0.03460574
p_int:  0.999330239
p_ni:  0.000669761
Data Source:  BioPlex
FURIN
Tchem
Family:  Enzyme
Novelty:  0.00055079
p_int:  0.999010489
p_ni:  0.000989512
Data Source:  BioPlex
MRM1
Tbio
Family:  Enzyme
Novelty:  0.08762499
p_int:  0.998192114
p_ni:  0.001807886
Score:  0.212
Data Source:  BioPlex,STRINGDB
GAST
Tbio
Novelty:  0.00011795
p_int:  0.997887773
p_ni:  0.002112227
Score:  0.181
Data Source:  BioPlex,STRINGDB
PTP4A1
Tchem
Family:  Enzyme
Novelty:  0.02863007
p_int:  0.99614665
p_ni:  0.00385335
Data Source:  BioPlex
TFPI2
Tbio
Novelty:  0.00475383
p_int:  0.995683068
p_ni:  0.004316932
Data Source:  BioPlex
DPH3
Tdark
Novelty:  0.05288317
p_int:  0.995621669
p_ni:  0.004378331
Score:  0.189
Data Source:  BioPlex,STRINGDB
QKI
Tbio
Novelty:  0.00966983
p_int:  0.994431404
p_ni:  0.005568596
Score:  0.151
Data Source:  BioPlex,STRINGDB
AVP
Tbio
Novelty:  0.00016475
p_int:  0.993466979
p_ni:  0.006533021
Data Source:  BioPlex
Publication Statistics
PubMed Score  70.65

PubMed score by year
PubTator Score  41.43

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: