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Tclin
KCNH1
Potassium voltage-gated channel subfamily H member 1

Protein Summary
Description
Pore-forming (alpha) subunit of a voltage-gated delayed rectifier potassium channel (PubMed:9738473, PubMed:11943152, PubMed:10880439, PubMed:22732247, PubMed:25556795, PubMed:27325704, PubMed:27005320, PubMed:27618660). Channel properties are modulated by subunit assembly (PubMed:11943152). Mediates IK(NI) current in myoblasts (PubMed:9738473). Involved in the regulation of cell proliferation and differentiation, in particular adipogenic and osteogenic differentiation in bone marrow-derived mesenchymal stem cells (MSCs) (PubMed:23881642). Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily H. This member is a pore- ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000271751
  • ENSP00000271751
  • ENSG00000143473
  • ENST00000638293
  • ENSP00000491986
  • ENSG00000283965
  • ENST00000638907
  • ENSP00000492550
  • ENST00000638960
  • ENSP00000492302
  • ENST00000639355
  • ENSP00000491578
  • ENST00000639420
  • ENSP00000492350
  • ENST00000639952
  • ENSP00000492697
  • ENST00000640402
  • ENSP00000491804
  • ENST00000640528
  • ENSP00000491725
  • ENST00000640710
  • ENSP00000492513

Symbol
  • EAG
  • EAG1
  • EAG
  • EAG1
  • ZLS1
  • TMBTS
  • h-eag
  • hEAG1
  • Kv10.1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
1
protein domain
1
gene perturbation
0.97
trait
0.86
transcription factor binding site profile
0.74


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 387.68   (req: < 5)
Gene RIFs: 75   (req: <= 3)
Antibodies: 199   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 387.68   (req: >= 5)
Gene RIFs: 75   (req: > 3)
Antibodies: 199   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 5
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 9
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
1
1
1
75.7
hematocrit
2
2
2
63
hemoglobin measurement
2
2
2
56.6
mathematical ability
1
1
1
56.3
progesterone measurement
1
1
1
34.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
1
75.7
hematocrit
2
63
hemoglobin measurement
2
56.6
mathematical ability
1
56.3
progesterone measurement
1
34.5
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (3)
Neuronal System (R-HSA-112316)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Neuronal System
Reactome
Potassium Channels
Reactome
Voltage gated Potassium channels
Name
Explore in Pharos
Explore in Source
Neuronal System
Potassium Channels
Voltage gated Potassium channels
Gene Ontology Terms (34)
Items per page:
10
1 – 10 of 10
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (67)
1 – 10 of 67
KCNAB2
Tbio
Family: IC
Novelty: 0.01752175
Score: 0.964
Data Source: STRINGDB
KCNAB1
Tbio
Family: IC
Novelty: 0.01413705
Score: 0.963
Data Source: STRINGDB
KCNAB3
Tbio
Family: IC
Novelty: 0.10128237
Score: 0.962
Data Source: STRINGDB
CALM3
Tclin
Novelty: 0.00461552
Score: 0.893
Data Source: STRINGDB
CALM2
Tclin
Novelty: 0.01876254
Score: 0.875
Data Source: STRINGDB
CALM1
Tclin
Novelty: 0.00308267
Score: 0.863
Data Source: STRINGDB
KCNC1
Tclin
Family: IC
Novelty: 0.00252943
Score: 0.775
Data Source: STRINGDB
CASK
Tchem
Family: Kinase
Novelty: 0.00856437
Score: 0.763
Data Source: STRINGDB
KCNMA1
Tclin
Family: IC
Novelty: 0.00088182
Score: 0.759
Data Source: STRINGDB
LPGAT1
Tbio
Family: Enzyme
Novelty: 0.06822609
Score: 0.757
Data Source: STRINGDB
Publication Statistics
PubMed Score  387.68

PubMed score by year
PubTator Score  217.82

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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