Tbio GADD45G Growth arrest and DNA damage-inducible protein GADD45 gamma

Protein Summary

Description

Involved in the regulation of growth and apoptosis. Mediates activation of stress-responsive MTK1/MEKK4 MAPKKK. This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The protein encoded by this gene responds to environmental stresses by mediating activation of the p38/JNK pathway via MTK1/MEKK4 kinase. The GADD45G is highly expressed in placenta. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• O95257
• Q5VZ87
• Q9C076

Gene Name

• GADD45G

Ensembl ID

• ENST00000252506
• ENSP00000252506
• ENSG00000130222

Symbol

• CR6
• DDIT2
• CR6
• DDIT2
• GRP17
• GADD45gamma

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	1
PubMedID	0.96
transcription factor binding site profile	0.96
virus perturbation	0.88
histone modification site profile	0.84

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 298.32   (req: < 5)

Gene RIFs: 39   (req: <= 3)

Antibodies: 732   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 298.32   (req: >= 5)

Gene RIFs: 39   (req: > 3)

Antibodies: 732   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0