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Tbio
IL18RAP
Interleukin-18 receptor accessory protein

Protein Summary
Description
Within the IL18 receptor complex, does not mediate IL18-binding, but involved in IL18-dependent signal transduction, leading to NF-kappa-B and JNK activation (PubMed:9792649, PubMed:14528293, PubMed:25500532). May play a role in IL18-mediated IFNG synthesis from T-helper 1 (Th1) cells (Probable). The protein encoded by this gene is an accessory subunit of the heterodimeric receptor for interleukin 18 (IL18), a proinflammatory cytokine involved in inducing cell-mediated immunity. This protein enhances the IL18-binding activity of the IL18 receptor and plays a role in signaling by IL18. Mutations in this gene are associated with Crohn's disease and inflammatory bowel disease, and susceptibility to celiac disease and leprosy. Alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Feb 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000264260
  • ENSP00000264260
  • ENSG00000115607
  • ENST00000409369
  • ENSP00000387201

Symbol
  • IL1R7
  • ACPL
  • CD218b
  • IL-1R7
  • IL18RB
  • CDw218b
  • IL-1R-7
  • IL-18RAcP
  • IL-1RAcPL
  • IL-18Rbeta
  • IL-18R-beta
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.74
protein domain
0.73
tissue sample
0.72
co-expressed gene
0.61
disease
0.57


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 66.19   (req: < 5)
Gene RIFs: 21   (req: <= 3)
Antibodies: 332   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 66.19   (req: >= 5)
Gene RIFs: 21   (req: > 3)
Antibodies: 332   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (36)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
6
9
8
6.4
99.7
16
9
1
1.2
99.2
eosinophil percentage of leukocytes
2
5
5
98.6
childhood onset asthma
3
4
0
1.2
98.5
serum ST2 measurement
1
6
6
96.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
8
6.4
99.7
1
1.2
99.2
eosinophil percentage of leukocytes
5
98.6
childhood onset asthma
0
1.2
98.5
serum ST2 measurement
6
96.9
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
interleukin 18 receptor accessory protein
VGNC:319
744277
Macaque
interleukin 18 receptor accessory protein
712046
Mouse
MGI:1338888
16174
Dog
interleukin 18 receptor accessory protein
VGNC:41954
481327
Horse
interleukin 18 receptor accessory protein
VGNC:51323
100050212
Species
Name
OMA
EggNOG
Inparanoid
Chimp
interleukin 18 receptor accessory protein
Macaque
interleukin 18 receptor accessory protein
Mouse
Dog
interleukin 18 receptor accessory protein
Horse
interleukin 18 receptor accessory protein
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O95256-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (11)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Immune System
Reactome
Interleukin-1 family signaling
Reactome
Interleukin-18 signaling
Reactome
Signaling by Interleukins
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Immune System
Interleukin-1 family signaling
Interleukin-18 signaling
Signaling by Interleukins
Gene Ontology Terms (14)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Protein-Protein Interactions (61)
1 – 10 of 61
PIGA
Tbio
Family:  Enzyme
Novelty:  0.00172769
p_int:  0.999989092
p_ni:  0.000010908
Score:  0.219
Data Source:  BioPlex,STRINGDB
PIGH
Tbio
Family:  Enzyme
Novelty:  0.0584561
p_int:  0.999752038
p_ni:  0.00024796
p_wrong:  2e-9
Score:  0.485
Data Source:  BioPlex,STRINGDB
IL18
Tbio
Novelty:  0.00022844
Score:  0.997
Data Source:  Reactome,STRINGDB
IL18R1
Tbio
Novelty:  0.01634385
Score:  0.991
Data Source:  Reactome,STRINGDB
IL18BP
Tbio
Novelty:  0.00838895
Score:  0.956
Data Source:  STRINGDB
IL37
Tbio
Novelty:  0.00499186
Score:  0.943
Data Source:  STRINGDB
STAT4
Tchem
Family:  TF
Novelty:  0.00251747
Score:  0.937
Data Source:  STRINGDB
MAPK8
Tchem
Family:  Kinase
Novelty:  0.00055723
Score:  0.92
Data Source:  STRINGDB
NFKB1
Tclin
Family:  TF
Novelty:  0.00198195
Score:  0.907
Data Source:  STRINGDB
RELA
Tchem
Family:  TF
Novelty:  0.0007137
Score:  0.9
Data Source:  STRINGDB
Publication Statistics
PubMed Score  66.19

PubMed score by year
PubTator Score  39.6

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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