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Tbio
ABCC6
Multidrug resistance-associated protein 6

Protein Summary
Description
Isoform 1: May participate directly in the active transport of drugs into subcellular organelles or influence drug distribution indirectly. Transports glutathione conjugates as leukotriene-c4 (LTC4) and N-ethylmaleimide S-glutathione (NEM-GS). Isoform 2: Inhibits TNF-alpha-mediated apoptosis through blocking one or more caspases. The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). The encoded protein, a member of the MRP subfamily, is involved in multi-drug resistance. Mutations in this gene cause pseudoxanthoma elasticum. Alternatively spliced transcript variants that encode different proteins have been described for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000205557
  • ENSP00000205557
  • ENSG00000091262
  • ENST00000456970
  • ENSP00000405002
  • ENST00000575728
  • ENSP00000461686
  • ENST00000600761
  • ENSP00000481979
  • ENSG00000275331
  • ENST00000622290
  • ENSP00000483331

Symbol
  • ARA
  • MRP6
  • ARA
  • PXE
  • MLP1
  • MRP6
  • PXE1
  • URG7
  • ABC34
  • GACI2
  • MOATE
  • MOAT-E
  • EST349056
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.98
protein domain
0.92
disease
0.71
biological term
0.69
gene perturbation
0.67


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 363.75   (req: < 5)
Gene RIFs: 85   (req: <= 3)
Antibodies: 150   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 363.75   (req: >= 5)
Gene RIFs: 85   (req: > 3)
Antibodies: 150   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (40)
XYLT1
Tbio
Family:  Enzyme
Novelty:  0.00557591
Score:  0.809
Data Source:  STRINGDB
XYLT2
Tbio
Family:  Enzyme
Novelty:  0.00273033
Score:  0.803
Data Source:  STRINGDB
GGCX
Tclin
Family:  Enzyme
Novelty:  0.00819484
Score:  0.761
Data Source:  STRINGDB
VKORC1
Tclin
Family:  Enzyme
Novelty:  0.00135838
Score:  0.714
Data Source:  STRINGDB
NOMO2
Tdark
Novelty:  0.17781596
Score:  0.689
Data Source:  STRINGDB
ENPP1
Tchem
Family:  Enzyme
Novelty:  0.00256132
Score:  0.672
Data Source:  STRINGDB
MRPS7
Tbio
Novelty:  0.00153134
Score:  0.651
Data Source:  STRINGDB
MGP
Tbio
Novelty:  0.00122665
Score:  0.591
Data Source:  STRINGDB
ELN
Tbio
Novelty:  0.00026801
Score:  0.587
Data Source:  STRINGDB
ABCG5
Tbio
Family:  Transporter
Novelty:  0.00340812
Score:  0.583
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (65)
ABC transporter disorders (R-HSA-5619084)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ABC transporter disorders
Reactome
ABC-family proteins mediated transport
Reactome
Defective ABCC6 causes pseudoxanthoma elasticum (PXE)
Reactome
Disease
Reactome
Disorders of transmembrane transporters
Name
Explore in Pharos
Explore in Source
ABC transporter disorders
ABC-family proteins mediated transport
Defective ABCC6 causes pseudoxanthoma elasticum (PXE)
Disease
Disorders of transmembrane transporters
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (16)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
ProtInc
Disease Associations ()
No disease associations found
GWAS Traits (4)
Items per page:
1 – 4 of 4
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
1
1
1
57.8
mean corpuscular volume
1
1
1
57.8
BMI-adjusted hip circumference
1
1
1
27.3
BMI-adjusted hip circumference
1
1
1
27.3
Items per page:
1 – 4 of 4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
1
57.8
mean corpuscular volume
1
57.8
BMI-adjusted hip circumference
1
27.3
BMI-adjusted hip circumference
1
27.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ATP binding cassette subfamily C member 6
742522
Mouse
MGI:1351634
27421
Rat
RGD:620268
81642
Dog
ATP binding cassette subfamily C member 6
489993
Horse
ATP binding cassette subfamily C member 6
VGNC:49471
100053637
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ATP binding cassette subfamily C member 6
Mouse
Rat
Dog
ATP binding cassette subfamily C member 6
Horse
ATP binding cassette subfamily C member 6
Publication Statistics
PubMed Score 363.75
PubMed score by year
PubTator Score 305.15
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title