Tbio KAT7 Histone acetyltransferase KAT7

Protein Summary

Description

Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Involved in H3K14 (histone H3 lysine 14) acetylation and cell proliferation (By similarity). Through chromatin acetylation it may regulate DNA replication and act as a coactivator of TP53-dependent transcription. Acts as a coactivator of the licensing factor CDT1 (PubMed:18832067). Specifically represses AR-mediated transcription. The protein encoded by this gene is part of the multimeric HBO1 complex, which possesses histone H4-specific acetyltransferase activity. This activity is required for functional replication origins and is involved in transcriptional activation of some genes. In both cases, the acetylation of histone H4 helps unfold chromatin so that the DNA can be accessed and replicated or transcribed. [provided by RefSeq, Oct 2016]

Uniprot Accession IDs

• O95251
• B3KN74
• B4DF85
• B4DFB4
• B4DFE0
• B4DGY4
• E7ER15
• G5E9K7

Gene Name

• KAT7

Ensembl ID

• ENST00000259021
• ENSP00000259021
• ENSG00000136504
• ENST00000424009
• ENSP00000398961
• ENST00000454930
• ENSP00000413415
• ENST00000509773
• ENSP00000424577
• ENST00000510819
• ENSP00000423385

Symbol

• HBO1
• HBOa
• MYST2
• HBO1
• HBOA
• MYST2
• ZC2HC7

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
drug perturbation	0.99
transcription factor binding site profile	0.94
histone modification site profile	0.84
disease perturbation	0.83
cell type or tissue	0.74

Protein Classes

PANTHER Classes

Protein / Transferase / Acetyltransferase / Histone Acetyltransferase Kat7

Protein / Transcription Factor / Zinc Finger Transcription Factor / Histone Acetyltransferase Kat7

Protein / Nucleic Acid Binding / Dna Binding Protein / Chromatin/chromatin-binding Protein / Histone Acetyltransferase Kat7

DTO Classes

Protein / Enzyme / Transferase / Acetyltransferase / Histone Acetyltransferase Kat7

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 79.31   (req: < 5)

Gene RIFs: 60   (req: <= 3)

Antibodies: 337   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 79.31   (req: >= 5)

Gene RIFs: 60   (req: > 3)

Antibodies: 337   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 23

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0