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Tbio
MBD4
Methyl-CpG-binding domain protein 4

Protein Summary
Description
Mismatch-specific DNA N-glycosylase involved in DNA repair. Has thymine glycosylase activity and is specific for G:T mismatches within methylated and unmethylated CpG sites. Can also remove uracil or 5-fluorouracil in G:U mismatches. Has no lyase activity. Was first identified as methyl-CpG-binding protein. The protein encoded by this gene is a member of a family of nuclear proteins related by the presence of a methyl-CpG binding domain (MBD). These proteins are capable of binding specifically to methylated DNA, and some members can also repress transcription from methylated gene promoters. This protein contains an MBD domain at the N-terminus that functions both in binding to methylated DNA and in protein interactions and a C-terminal mismatch-specific glycosylase domain that is involved in DNA repair. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000249910
  • ENSP00000249910
  • ENSG00000129071
  • ENST00000393278
  • ENSP00000376959
  • ENST00000429544
  • ENSP00000394080
  • ENST00000503197
  • ENSP00000424873
  • ENST00000507208
  • ENSP00000422327

Symbol
  • MED1
  • MED1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.95
disease perturbation
0.83
cell type or tissue
0.76
histone modification site profile
0.75
transcription factor perturbation
0.74


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 104.89   (req: < 5)
Gene RIFs: 35   (req: <= 3)
Antibodies: 213   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 104.89   (req: >= 5)
Gene RIFs: 35   (req: > 3)
Antibodies: 213   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
methyl-CpG binding domain 4, DNA glycosylase
VGNC:2038
738526
Macaque
methyl-CpG binding domain 4, DNA glycosylase
720557
Mouse
MGI:1333850
17193
Rat
RGD:1585874
680915
Dog
methyl-CpG binding domain 4, DNA glycosylase
VGNC:43052
100684130
Species
Name
OMA
EggNOG
Inparanoid
Chimp
methyl-CpG binding domain 4, DNA glycosylase
Macaque
methyl-CpG binding domain 4, DNA glycosylase
Mouse
Rat
Dog
methyl-CpG binding domain 4, DNA glycosylase
Protein Structure (14 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O95243-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 14
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (9)
Base Excision Repair (R-HSA-73884)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Base Excision Repair
Reactome
Base-Excision Repair, AP Site Formation
Reactome
Cleavage of the damaged pyrimidine
Reactome
DNA Repair
Reactome
Depyrimidination
Name
Explore in Pharos
Explore in Source
Base Excision Repair
Base-Excision Repair, AP Site Formation
Cleavage of the damaged pyrimidine
DNA Repair
Depyrimidination
Gene Ontology Terms (13)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (67)
1 – 10 of 67
APEX1
Tchem
Family: Enzyme
Novelty: 0.00037532
Score: 0.955
Data Source: Reactome,STRINGDB
MLH1
Tbio
Novelty: 0.00034212
Score: 0.946
Data Source: STRINGDB
TDG
Tbio
Family: Enzyme
Novelty: 0.00283178
Score: 0.849
Data Source: STRINGDB
SMUG1
Tbio
Family: Enzyme
Novelty: 0.01345774
Score: 0.8
Data Source: STRINGDB
DNMT3B
Tchem
Family: Epigenetic
Novelty: 0.00118766
Score: 0.778
Data Source: STRINGDB
UHRF1
Tbio
Family: Epigenetic
Novelty: 0.00482565
Score: 0.731
Data Source: STRINGDB
DNMT1
Tclin
Family: Enzyme
Novelty: 0.00042336
Score: 0.719
Data Source: STRINGDB
TRDMT1
Tbio
Family: Enzyme
Novelty: 0.00712649
Score: 0.702
Data Source: STRINGDB
UNG
Tbio
Family: Enzyme
Novelty: 0.00268354
Score: 0.69
Data Source: STRINGDB
ZBTB33
Tbio
Family: TF
Novelty: 0.01327474
Score: 0.674
Data Source: STRINGDB
Publication Statistics
PubMed Score  104.89

PubMed score by year
PubTator Score  82.91

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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