Tbio MBD4 Methyl-CpG-binding domain protein 4

Protein Summary

Description

Mismatch-specific DNA N-glycosylase involved in DNA repair. Has thymine glycosylase activity and is specific for G:T mismatches within methylated and unmethylated CpG sites. Can also remove uracil or 5-fluorouracil in G:U mismatches. Has no lyase activity. Was first identified as methyl-CpG-binding protein. The protein encoded by this gene is a member of a family of nuclear proteins related by the presence of a methyl-CpG binding domain (MBD). These proteins are capable of binding specifically to methylated DNA, and some members can also repress transcription from methylated gene promoters. This protein contains an MBD domain at the N-terminus that functions both in binding to methylated DNA and in protein interactions and a C-terminal mismatch-specific glycosylase domain that is involved in DNA repair. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2013]

Uniprot Accession IDs

• O95243
• B4DZN2
• D3DNC3
• D3DNC4
• E9PEE4
• Q2MD36
• Q7Z4T3
• Q96F09

Gene Name

• MBD4

Ensembl ID

• ENST00000249910
• ENSP00000249910
• ENSG00000129071
• ENST00000393278
• ENSP00000376959
• ENST00000429544
• ENSP00000394080
• ENST00000503197
• ENSP00000424873
• ENST00000507208
• ENSP00000422327

Symbol

• MED1
• MED1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.95
disease perturbation	0.83
cell type or tissue	0.76
histone modification site profile	0.75
transcription factor perturbation	0.74

Protein Classes

PANTHER Classes

Protein / Transferase / Methyltransferase / Methyl-cpg-binding Domain Protein 4

Protein / Nucleic Acid Binding / Nuclease / Methyl-cpg-binding Domain Protein 4

DTO Classes

Protein / Enzyme / Transferase / Methyltransferase / Methyl-cpg-binding Domain Protein 4

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 124.56   (req: < 5)

Gene RIFs: 44   (req: <= 3)

Antibodies: 213   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 124.56   (req: >= 5)

Gene RIFs: 44   (req: > 3)

Antibodies: 213   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0