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Tbio
SPDEF
SAM pointed domain-containing Ets transcription factor

Protein Classes
Protein Summary
Description
May function as an androgen-independent transactivator of the prostate-specific antigen (PSA) promoter. Binds to 5'-GGAT-3' DNA sequences. May play a role in the regulation of the prostate gland and/or prostate cancer development. Acts as a transcriptional activator for SERPINB5 promoter. The protein encoded by this gene belongs to the ETS family of transcription factors. It is highly expressed in the prostate epithelial cells, and functions as an androgen-independent transactivator of prostate-specific antigen (PSA) promoter. Higher expression of this protein has also been reported in brain, breast, lung and ovarian tumors, compared to the corresponding normal tissues, and it shows better tumor-association than other cancer-associated molecules, making it a more suitable target for developing specific cancer therapies. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000374037
  • ENSP00000363149
  • ENSG00000124664
  • ENST00000544425
  • ENSP00000442715

Symbol
  • PDEF
  • PSE
  • PDEF
  • bA375E1.3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.81
small molecule perturbation
0.73
virus perturbation
0.68
tissue sample
0.67
cell type or tissue
0.62


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 174.91   (req: < 5)
Gene RIFs: 48   (req: <= 3)
Antibodies: 205   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 174.91   (req: >= 5)
Gene RIFs: 48   (req: > 3)
Antibodies: 205   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
appendicular lean mass
2
1
2
92.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
appendicular lean mass
2
92.6
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (3)
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
PathwayCommons: panther
PDGF signaling pathway
PathwayCommons: pid
Regulation of Androgen receptor activity
PathwayCommons: netpath
AndrogenReceptor
Name
Explore in Pharos
Explore in Source
PDGF signaling pathway
Regulation of Androgen receptor activity
AndrogenReceptor
Protein-Protein Interactions (69)
1 – 10 of 69
PRDM16
Tbio
Family: TF; Epigenetic
Novelty: 0.00261891
p_int: 0.999999988
p_wrong: 1.2e-8
Score: 0.544
Data Source: BioPlex,STRINGDB
MECOM
Tbio
Family: TF; Epigenetic
Novelty: 0.00500501
p_int: 0.999999759
p_ni: 2.41e-7
Score: 0.267
Data Source: BioPlex,STRINGDB
C5orf30
Tdark
Novelty: 0.2072045
p_int: 0.999990514
p_ni: 0.000009478
p_wrong: 9e-9
Score: 0.834
Data Source: BioPlex,STRINGDB
MYO5C
Tbio
Novelty: 0.05680943
p_int: 0.993300155
p_ni: 0.006699845
Score: 0.282
Data Source: BioPlex,STRINGDB
FASTKD1
Tbio
Family: Enzyme
Novelty: 0.64864074
p_int: 0.893167017
p_ni: 0.106832983
Score: 0.204
Data Source: BioPlex,STRINGDB
SLC4A2
Tbio
Family: Transporter
Novelty: 0.02448062
p_int: 0.881970772
p_ni: 0.118029228
Score: 0.181
Data Source: BioPlex,STRINGDB
PRMT8
Tchem
Family: Epigenetic
Novelty: 0.04213384
p_int: 0.835334976
p_ni: 0.164665024
Score: 0.192
Data Source: BioPlex,STRINGDB
UNC119
Tchem
Novelty: 0.00396292
p_int: 0.798273642
p_ni: 0.201726358
Score: 0.546
Data Source: BioPlex,STRINGDB
AR
Tclin
Family: NR
Novelty: 0.00013531
Score: 0.804
Data Source: STRINGDB
MUC5AC
Tbio
Novelty: 0.00074159
Score: 0.802
Data Source: STRINGDB
Publication Statistics
PubMed Score  174.91

PubMed score by year
PubTator Score  69.04

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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