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Tbio
LRAT
Lecithin retinol acyltransferase

Protein Summary
Description
Transfers the acyl group from the sn-1 position of phosphatidylcholine to all-trans retinol, producing all-trans retinyl esters. Retinyl esters are storage forms of vitamin A. LRAT plays a critical role in vision. It provides the all-trans retinyl ester substrates for the isomerohydrolase which processes the esters into 11-cis-retinol in the retinal pigment epithelium; due to a membrane-associated alcohol dehydrogenase, 11 cis-retinol is oxidized and converted into 11-cis-retinaldehyde which is the chromophore for rhodopsin and the cone photopigments. The protein encoded by this gene localizes to the endoplasmic reticulum, where it catalyzes the esterification of all-trans-retinol into all-trans-retinyl ester. This reaction is an important step in vitamin A metabolism in the visual system. Mutations in this gene have been associated with early-onset severe retinal dystrophy and Leber congenital amaurosis 14. Alternative splicing results in multiple transcript variants. [provided by Ref ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000336356
  • ENSP00000337224
  • ENSG00000121207
  • ENST00000507827
  • ENSP00000426761

Symbol
  • LCA14
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
metabolite
0.8
cell type or tissue
0.76
molecular function
0.73
PubMedID
0.61
histone modification site profile
0.55


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 183.41   (req: < 5)
Gene RIFs: 28   (req: <= 3)
Antibodies: 243   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 183.41   (req: >= 5)
Gene RIFs: 28   (req: > 3)
Antibodies: 243   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
fibrinogen measurement
8
14
14
12.9
99.8
venous thromboembolism
7
4
1
1.2
97.6
low density lipoprotein cholesterol measurement
3
3
3
89.2
prothrombin time measurement
1
1
1
72.9
total cholesterol measurement
3
2
3
70.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
fibrinogen measurement
14
12.9
99.8
venous thromboembolism
1
1.2
97.6
low density lipoprotein cholesterol measurement
3
89.2
prothrombin time measurement
1
72.9
total cholesterol measurement
3
70.5
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
lecithin retinol acyltransferase
VGNC:48914
471328
Mouse
MGI:1891259
79235
Rat
RGD:68362
64047
Dog
lecithin retinol acyltransferase
VGNC:49606
482660
Horse
lecithin retinol acyltransferase
VGNC:50484
100069704
Species
Name
OMA
EggNOG
Inparanoid
Chimp
lecithin retinol acyltransferase
Mouse
Rat
Dog
lecithin retinol acyltransferase
Horse
lecithin retinol acyltransferase
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-O95237-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (46)
Disease (R-HSA-1643685)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 14
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Disease
Reactome
Diseases associated with visual transduction
Reactome
Diseases of signal transduction
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Name
Explore in Pharos
Explore in Source
Disease
Diseases associated with visual transduction
Diseases of signal transduction
G alpha (i) signalling events
GPCR downstream signalling
Gene Ontology Terms (20)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (105)
1 – 10 of 105
NME2P1
Tdark
Family:  Kinase
p_int:  0.967035386
p_ni:  0.032855731
p_wrong:  0.000108883
Data Source:  BioPlex
RBP1
Tbio
Novelty:  0.00199929
Score:  0.989
Data Source:  STRINGDB
RPE65
Tbio
Family:  Enzyme
Novelty:  0.00147985
Score:  0.988
Data Source:  STRINGDB
RDH12
Tbio
Family:  Enzyme
Novelty:  0.016003
Score:  0.979
Data Source:  STRINGDB
RBP2
Tbio
Novelty:  0.00823654
Score:  0.978
Data Source:  STRINGDB
RDH5
Tbio
Family:  Enzyme
Novelty:  0.0111079
Score:  0.975
Data Source:  STRINGDB
CYP26A1
Tchem
Family:  Enzyme
Novelty:  0.00281805
Score:  0.97
Data Source:  STRINGDB
RDH10
Tbio
Family:  Enzyme
Novelty:  0.03049914
Score:  0.969
Data Source:  STRINGDB
RDH11
Tbio
Family:  Enzyme
Novelty:  0.02758936
Score:  0.966
Data Source:  STRINGDB
CES1
Tchem
Family:  Enzyme
Novelty:  0.00092608
Score:  0.957
Data Source:  STRINGDB
Publication Statistics
PubMed Score  183.41

PubMed score by year
PubTator Score  96.54

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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