Tchem KIF20A Kinesin-like protein KIF20A

Protein Summary

Description

Mitotic kinesin required for chromosome passenger complex (CPC)-mediated cytokinesis. Following phosphorylation by PLK1, involved in recruitment of PLK1 to the central spindle. Interacts with guanosine triphosphate (GTP)-bound forms of RAB6A and RAB6B. May act as a motor required for the retrograde RAB6 regulated transport of Golgi membranes and associated vesicles along microtubules. Has a microtubule plus end-directed motility.

Uniprot Accession IDs

• O95235
• B4DL79
• D3DQB6

Gene Name

• KIF20A

Ensembl ID

• ENST00000394894
• ENSP00000378356
• ENSG00000112984
• ENST00000508792
• ENSP00000420880

Symbol

• MKLP2
• RAB6KIFL
• MKLP2
• RAB6KIFL

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.99
transcription factor perturbation	0.94
histone modification site profile	0.91
small molecule perturbation	0.82
transcription factor binding site profile	0.81

Protein Classes

PANTHER Classes

Protein / Cytoskeletal Protein / Microtubule Family Cytoskeletal Protein / Microtubule Binding Motor Protein / Kinesin-like Protein Kif20a

DTO Classes

Protein / Cellular Structure / Microtubule Family Cytoskeletal Protein / Microtubule Binding Motor Protein / Kinesin-like Protein Kif20a

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 89.47   (req: < 5)

Gene RIFs: 44   (req: <= 3)

Antibodies: 270   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 89.47   (req: >= 5)

Gene RIFs: 44   (req: > 3)

Antibodies: 270   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0