You are using an outdated browser. Please upgrade your browser to improve your experience.

Tchem
KIF20A
Kinesin-like protein KIF20A

Protein Summary
Description
Mitotic kinesin required for chromosome passenger complex (CPC)-mediated cytokinesis. Following phosphorylation by PLK1, involved in recruitment of PLK1 to the central spindle. Interacts with guanosine triphosphate (GTP)-bound forms of RAB6A and RAB6B. May act as a motor required for the retrograde RAB6 regulated transport of Golgi membranes and associated vesicles along microtubules. Has a microtubule plus end-directed motility.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000394894
  • ENSP00000378356
  • ENSG00000112984
  • ENST00000508792
  • ENSP00000420880

Symbol
  • MKLP2
  • RAB6KIFL
  • MKLP2
  • RAB6KIFL
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.99
transcription factor perturbation
0.94
histone modification site profile
0.91
small molecule perturbation
0.82
transcription factor binding site profile
0.81


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 80.3   (req: < 5)
Gene RIFs: 25   (req: <= 3)
Antibodies: 270   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 80.3   (req: >= 5)
Gene RIFs: 25   (req: > 3)
Antibodies: 270   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (364)
EPN1
Tbio
Novelty:  0.01788784
p_int:  0.999956127
p_ni:  0.000043868
p_wrong:  5e-9
Data Source:  BioPlex
STK25
Tchem
Family:  Kinase
Novelty:  0.03229688
p_int:  0.999948742
p_ni:  0.00005123
p_wrong:  2.9e-8
Score:  0.231
Data Source:  BioPlex,STRINGDB
CARD10
Tbio
Family:  Enzyme
Novelty:  0.01960502
p_int:  0.999916411
p_ni:  0.00000814
p_wrong:  0.000075448
Score:  0.214
Data Source:  BioPlex,STRINGDB
RABEP1
Tbio
Family:  Enzyme
Novelty:  0.02318446
p_int:  0.999289039
p_ni:  0.000710358
p_wrong:  6.03e-7
Data Source:  BioPlex
MAP7D2
Tdark
Novelty:  0.70744439
p_int:  0.99881277
p_ni:  0.001187023
p_wrong:  2.08e-7
Score:  0.187
Data Source:  BioPlex,STRINGDB
BTRC
Tbio
Novelty:  0.00293475
p_int:  0.995538064
p_ni:  0.004460617
p_wrong:  0.000001318
Data Source:  BioPlex
CAMK1
Tchem
Family:  Kinase
Novelty:  0.01239891
p_int:  0.994623532
p_ni:  0.005376468
Score:  0.186
Data Source:  BioPlex,STRINGDB
TNNC2
Tbio
Novelty:  0.07759506
p_int:  0.9806323
p_ni:  0.019340016
p_wrong:  0.000027685
Data Source:  BioPlex
IFT20
Tbio
Novelty:  0.03005088
p_int:  0.94101458
p_ni:  0.009538715
p_wrong:  0.049446706
Data Source:  BioPlex
EIF2B5
Tbio
Novelty:  0.0102209
p_int:  0.936480076
p_ni:  0.008571836
p_wrong:  0.054948088
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (17)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 15
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
COPI-dependent Golgi-to-ER retrograde traffic
Reactome
Cell Cycle
Reactome
Cell Cycle, Mitotic
Reactome
Factors involved in megakaryocyte development and platelet production
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
COPI-dependent Golgi-to-ER retrograde traffic
Cell Cycle
Cell Cycle, Mitotic
Factors involved in megakaryocyte development and platelet production
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (22)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
2
0
1.1
83.7
self reported educational attainment
1
1
1
30.2
mathematical ability
1
1
1
30.2
1
1
1
3.9
Eczema
1
1
0
1
2.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
83.7
self reported educational attainment
1
30.2
mathematical ability
1
30.2
1
3.9
Eczema
0
1
2.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
kinesin family member 20A
VGNC:4062
462091
Macaque
kinesin family member 20A
716533
Mouse
MGI:1201682
19348
Rat
RGD:1307695
361308
Dog
kinesin family member 20A
VGNC:42394
474693
Species
Name
OMA
EggNOG
Inparanoid
Chimp
kinesin family member 20A
Macaque
kinesin family member 20A
Mouse
Rat
Dog
kinesin family member 20A
Publication Statistics
PubMed Score 80.30
PubMed score by year
PubTator Score 49.43
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title