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Tdark
OR6A2
Olfactory receptor 6A2

Protein Summary
Description
Odorant receptor. Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000332601
  • ENSP00000330384
  • ENSG00000184933
  • ENST00000641196
  • ENSP00000492990

Symbol
  • OR6A1
  • OR6A2P
  • I7
  • OR6A1
  • OR6A2P
  • OR11-55
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue sample
0.75
gene perturbation
0.74
cell type or tissue
0.58
disease perturbation
0.56
tissue
0.44


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.86   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 40   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.86   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 40   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mammographic density measurement
1
1
1
1.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mammographic density measurement
1
1.8
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
olfactory receptor family 6 subfamily A member 2
VGNC:13380
107967010
Mouse
MGI:97432
18317
Cow
olfactory receptor, family 6, subfamily A, member 2
528930
Pig
olfactory receptor 226
100738942
Platypus
olfactory receptor 226-like
100680588
Species
Name
OMA
EggNOG
Inparanoid
Chimp
olfactory receptor family 6 subfamily A member 2
Mouse
Cow
olfactory receptor, family 6, subfamily A, member 2
Pig
olfactory receptor 226
Platypus
olfactory receptor 226-like
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-O95222-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (7)
G alpha (s) signalling events (R-HSA-418555)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
G alpha (s) signalling events
Reactome
GPCR downstream signalling
Reactome
Olfactory Signaling Pathway
Reactome
Signal Transduction
Reactome
Signaling by GPCR
Name
Explore in Pharos
Explore in Source
G alpha (s) signalling events
GPCR downstream signalling
Olfactory Signaling Pathway
Signal Transduction
Signaling by GPCR
Gene Ontology Terms (6)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (33)
1 – 10 of 33
KIAA1549
Tbio
Novelty:  0.01224835
p_int:  0.999917645
p_ni:  0.000082355
Data Source:  BioPlex
GNB1
Tbio
Novelty:  0.02477955
Score:  0.913
Data Source:  STRINGDB
RTP3
Tbio
Novelty:  0.05721596
Score:  0.91
Data Source:  STRINGDB
GNAL
Tbio
Novelty:  0.01757098
Score:  0.909
Data Source:  STRINGDB
RTP1
Tbio
Novelty:  0.0278378
Score:  0.907
Data Source:  STRINGDB
RTP4
Tbio
Novelty:  0.05959975
Score:  0.905
Data Source:  STRINGDB
RTP2
Tbio
Novelty:  0.05972678
Score:  0.905
Data Source:  STRINGDB
REEP2
Tdark
Novelty:  0.23897587
Score:  0.901
Data Source:  STRINGDB
REEP4
Tbio
Novelty:  0.37950931
Score:  0.901
Data Source:  STRINGDB
REEP3
Tbio
Novelty:  0.19673119
Score:  0.901
Data Source:  STRINGDB
Publication Statistics
PubMed Score  10.86

PubMed score by year
PubTator Score  12.33

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer