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Tbio
SNX4
Sorting nexin-4

Protein Summary
Description
Involved in the regulation of endocytosis and in several stages of intracellular trafficking (PubMed:12668730). Plays a role in recycling endocytosed transferrin receptor and prevent its degradation. This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein associated with the long isoform of the leptin receptor and with receptor tyrosine kinases for platelet-derived growth factor, insulin, and epidermal growth factor in cell cultures, but its function is unknown. This protein may form oligomeric complexes with family members. Two transcript variants, one protein coding and the other non-protein coding, have been found for this gene. [provided by RefSeq, Nov 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000251775
  • ENSP00000251775
  • ENSG00000114520

Symbol
  • ATG24B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.99
disease perturbation
0.93
interacting protein
0.88
histone modification site profile
0.8
transcription factor perturbation
0.74


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.04   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 228   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.04   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 228   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
1
1
7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
7
Gene Ontology Terms (15)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Protein-Protein Interactions (168)
1 – 10 of 168
SNX30
Tdark
Novelty: 78
p_int: 1
Score: 0.747
Data Source: BioPlex,STRINGDB
SNX7
Tbio
Novelty: 0.1473151
p_int: 0.999999988
p_ni: 1.2e-8
Score: 0.567
Data Source: BioPlex,STRINGDB
ANKMY2
Tdark
Novelty: 0.50777631
p_int: 0.999731179
p_ni: 0.000268821
Score: 0.233
Data Source: BioPlex,STRINGDB
MECR
Tbio
Family: Enzyme
Novelty: 0.01395965
p_int: 0.99948063
p_ni: 0.000519261
p_wrong: 1.08e-7
Data Source: BioPlex
ABCB10
Tbio
Family: Transporter
Novelty: 0.00351852
p_int: 0.984496356
p_ni: 0.015503644
Score: 0.261
Data Source: BioPlex,STRINGDB
CACYBP
Tbio
Novelty: 0.02207811
p_int: 0.933642029
p_ni: 0.066357971
Score: 0.696
Data Source: BioPlex,STRINGDB
DYNC1LI1
Tbio
Novelty: 0.02164556
Score: 0.928
Data Source: STRINGDB
STX16
Tbio
Novelty: 0.02462523
Score: 0.927
Data Source: STRINGDB
VAMP7
Tbio
Novelty: 0.00900603
Score: 0.924
Data Source: STRINGDB
VAMP2
Tbio
Novelty: 0.00187736
Score: 0.921
Data Source: STRINGDB
Publication Statistics
PubMed Score  20.04

PubMed score by year
PubTator Score  10.22

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer