Tbio ZRANB2 Zinc finger Ran-binding domain-containing protein 2

Protein Summary

Description

Splice factor required for alternative splicing of TRA2B/SFRS10 transcripts. May interfere with constitutive 5'-splice site selection.

Uniprot Accession IDs

• O95218
• D3DQ75
• Q53GS3
• Q59F92
• Q5VV33
• Q5VV34
• Q8IXN6
• Q9UP63

Gene Name

• ZRANB2

Ensembl ID

• ENST00000254821
• ENSP00000254821
• ENSG00000132485
• ENST00000370920
• ENSP00000359958
• ENST00000611683
• ENSP00000482026

Symbol

• ZIS
• ZNF265
• ZIS
• ZIS1
• ZIS2
• ZNF265

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
ligand (protein) perturbation	0.99
interacting protein	0.91
drug perturbation	0.87
transcription factor binding site profile	0.85
small molecule perturbation	0.77

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.59   (req: < 5)

Gene RIFs: 4   (req: <= 3)

Antibodies: 264   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.59   (req: >= 5)

Gene RIFs: 4   (req: > 3)

Antibodies: 264   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0