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Tbio
EPN2
Epsin-2

Protein Summary
Description
Plays a role in the formation of clathrin-coated invaginations and endocytosis. This gene encodes a protein which interacts with clathrin and adaptor-related protein complex 2, alpha 1 subunit. The protein is found in a brain-derived clathrin-coated vesicle fraction and localizes to the peri-Golgi region and the cell periphery. The protein is thought to be involved in clathrin-mediated endocytosis. Alternate splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000314728
  • ENSP00000320543
  • ENSG00000072134
  • ENST00000347697
  • ENSP00000261495
  • ENST00000395618
  • ENSP00000378980
  • ENST00000395620
  • ENSP00000378982

Symbol
  • KIAA1065
  • EHB21
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.79
kinase perturbation
0.76
transcription factor perturbation
0.68
transcription factor
0.66
kinase
0.63


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.17   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 291   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.17   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 291   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (181)
1 – 10 of 181
EPN3
Tbio
Novelty:  0.12685855
p_int:  1
Score:  0.87
Data Source:  BioPlex,STRINGDB
EPS15
Tchem
Novelty:  0.00451447
Score:  0.992
Data Source:  STRINGDB
GAK
Tchem
Family:  Kinase
Novelty:  0.00731928
Score:  0.986
Data Source:  STRINGDB
HIP1R
Tbio
Novelty:  0.02502713
Score:  0.983
Data Source:  STRINGDB
CLTC
Tbio
Novelty:  0.00256674
Score:  0.981
Data Source:  STRINGDB
EPS15L1
Tbio
Novelty:  0.06929299
Score:  0.976
Data Source:  STRINGDB
HIP1
Tbio
Novelty:  0.03790722
Score:  0.969
Data Source:  STRINGDB
ITSN1
Tbio
Novelty:  0.01327346
Score:  0.964
Data Source:  STRINGDB
SNAP91
Tbio
Novelty:  0.0083886
Score:  0.962
Data Source:  STRINGDB
AP2A1
Tbio
Novelty:  0.08554974
Score:  0.96
Data Source:  STRINGDB
Pathways (6)
Cargo recognition for clathrin-mediated endocytosis (R-HSA-8856825)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cargo recognition for clathrin-mediated endocytosis
Reactome
Clathrin-mediated endocytosis
Reactome
Membrane Trafficking
Reactome
Vesicle-mediated transport
Name
Explore in Pharos
Explore in Source
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
Membrane Trafficking
Vesicle-mediated transport
Gene Ontology Terms (10)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
3
2
3
72.4
diastolic blood pressure
1
1
1
59.9
mathematical ability
1
1
1
53.7
2
2
1
1.1
52.3
lifestyle measurement
1
1
1
35
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
3
72.4
diastolic blood pressure
1
59.9
mathematical ability
1
53.7
1
1.1
52.3
lifestyle measurement
1
35
Find similar targets by:
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
epsin 2
VGNC:9274
454498
Macaque
epsin 2
702600
Mouse
MGI:1333766
13855
Rat
RGD:619773
60443
Dog
epsin 2
VGNC:40420
489533
Species
Name
OMA
EggNOG
Inparanoid
Chimp
epsin 2
Macaque
epsin 2
Mouse
Rat
Dog
epsin 2
Publication Statistics
PubMed Score 17.17
PubMed score by year
PubTator Score 3.48
PubTator score by year