Tbio KLHL2 Kelch-like protein 2

Protein Summary

Description

Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation (By similarity). Responsible for degradative ubiquitination of the WNK kinases WNK1, WNK3 and WNK4. Plays a role in the reorganization of the actin cytoskeleton. Promotes growth of cell projections in oligodendrocyte precursors.

Uniprot Accession IDs

• O95198
• A6NCM7
• B2RD18
• B4DFH7
• F5H6M3
• Q8N484
• Q8TBH5

Gene Name

• KLHL2

Ensembl ID

• ENST00000226725
• ENSP00000226725
• ENSG00000109466
• ENST00000514860
• ENSP00000424198
• ENST00000538127
• ENSP00000437526

Symbol

• MAV
• MAYVEN
• ABP-KELCH

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.92
histone modification site profile	0.81
kinase perturbation	0.76
transcription factor perturbation	0.74
tissue sample	0.64

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 375.16   (req: < 5)

Gene RIFs: 4   (req: <= 3)

Antibodies: 261   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 375.16   (req: >= 5)

Gene RIFs: 4   (req: > 3)

Antibodies: 261   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0