Protein Summary
May be involved in membrane trafficking in the early secretory pathway. Inhibits BACE1 activity and amyloid precursor protein processing. May induce caspase-8 cascade and apoptosis. May favor BCL2 translocation to the mitochondria upon endoplasmic reticulum stress. In case of enteroviruses infection, RTN3 may be involved in the viral replication or pathogenesis. Induces the formation of endoplasmic reticulum tubules (PubMed:25612671). This gene belongs to the reticulon family of highly conserved genes that are preferentially expressed in neuroendocrine tissues. This family of proteins interact with, and modulate the activity of beta-amyloid converting enzyme 1 (BACE1), and the production of amyloid-beta. An increase in the expression of any reticulon protein substantially reduces the production of amyloid-beta, suggesting that reticulon proteins are negative modulators of BACE1 in cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene ...more
- ENST00000339997
- ENSP00000344106
- ENSG00000133318
- ENST00000341307
- ENSP00000340903
- ENST00000354497
- ENSP00000346492
- ENST00000356000
- ENSP00000348279
- ENST00000377819
- ENSP00000367050
- ENST00000537981
- ENSP00000440874
- ENST00000540798
- ENSP00000442733
- ASYIP
- NSPL2
- HAP
- ASYIP
- NSPL2
- NSPLII
- RTN3-A1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
disease perturbation | 1 | ||
kinase perturbation | 1 | ||
virus perturbation | 0.98 | ||
ligand (protein) perturbation | 0.96 | ||
transcription factor binding site profile | 0.77 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 53.85 (req: < 5)
Gene RIFs: 35 (req: <= 3)
Antibodies: 178 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 53.85 (req: >= 5)
Gene RIFs: 35 (req: > 3)
Antibodies: 178 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 5
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (58)
RTN4
Novelty: 0.00080371
p_int: 0.787187221
p_ni: 0.212812779
Score: 0.905
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (4)
Reactome (3)
KEGG (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Neuronal System | ||||
Reactome | Protein-protein interactions at synapses | ||||
Reactome | Synaptic adhesion-like molecules | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Neuronal System | ||||
Protein-protein interactions at synapses | ||||
Synaptic adhesion-like molecules | ||||
Viral Interactions (0)
Gene Ontology Terms (12)
Components (7)
Processes (5)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | HPA | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Traceable Author Statement (TAS) | ProtInc | |||
Traceable Author Statement (TAS) | Reactome | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-SubCell | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Disease Associations ()
GWAS Traits (1)
Items per page:
1 – 1 of 1
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
low density lipoprotein cholesterol measurement | 1 | 1 | 1 | 5.9 | |||||
Items per page:
1 – 1 of 1
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
low density lipoprotein cholesterol measurement | 1 | 5.9 | |||||
Find similar targets by:
IDG Resources
Orthologs (8)
1 – 5 of 8
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | reticulon 3 | VGNC:11663 | 451281 | |||||
Macaque | reticulon 3 | 718173 | ||||||
Mouse | MGI:1339970 | 20168 | ||||||
Rat | RGD:620988 | 140945 | ||||||
Pig | reticulon 3 | 100512087 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | reticulon 3 | |||||
Macaque | reticulon 3 | |||||
Mouse | ||||||
Rat | ||||||
Pig | reticulon 3 | |||||
Publication Statistics
PubMed Score 53.85
PubMed score by year
PubTator Score 115.75
PubTator score by year
Related Publications
Text Mined References (59)
GeneRif Annotations (35)
Items per page:
0 of 0
PMID | Year | Title |
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