Tbio RTN3 Reticulon-3

Protein Summary

Description

May be involved in membrane trafficking in the early secretory pathway. Inhibits BACE1 activity and amyloid precursor protein processing. May induce caspase-8 cascade and apoptosis. May favor BCL2 translocation to the mitochondria upon endoplasmic reticulum stress. In case of enteroviruses infection, RTN3 may be involved in the viral replication or pathogenesis. Induces the formation of endoplasmic reticulum tubules (PubMed:25612671). This gene belongs to the reticulon family of highly conserved genes that are preferentially expressed in neuroendocrine tissues. This family of proteins interact with, and modulate the activity of beta-amyloid converting enzyme 1 (BACE1), and the production of amyloid-beta. An increase in the expression of any reticulon protein substantially reduces the production of amyloid-beta, suggesting that reticulon proteins are negative modulators of BACE1 in cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene, and pseudogenes of this gene are located on chromosomes 4 and 12. [provided by RefSeq, May 2012]

Uniprot Accession IDs

• O95197
• B3KQS2
• B7Z308
• B7Z4M0
• F5H774
• Q147U9
• Q496K2
• Q53GN3
• Q59EP0
• Q5UEP2
• Q6T930
• Q7RTM7
• Q7RTM8
• Q7RTN3

Gene Name

• RTN3

Ensembl ID

• ENST00000339997
• ENSP00000344106
• ENSG00000133318
• ENST00000341307
• ENSP00000340903
• ENST00000354497
• ENSP00000346492
• ENST00000356000
• ENSP00000348279
• ENST00000377819
• ENSP00000367050
• ENST00000537981
• ENSP00000440874
• ENST00000540798
• ENSP00000442733

Symbol

• ASYIP
• NSPL2
• HAP
• ASYIP
• NSPL2
• NSPLII
• RTN3-A1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	1
kinase perturbation	1
virus perturbation	0.98
ligand (protein) perturbation	0.96
transcription factor binding site profile	0.77

Related Tools

GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 50.64   (req: < 5)

Gene RIFs: 35   (req: <= 3)

Antibodies: 178   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 50.64   (req: >= 5)

Gene RIFs: 35   (req: > 3)

Antibodies: 178   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Orthologs (8)

1 – 5 of 8

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	reticulon 3	VGNC:11663	451281
Macaque	reticulon 3		718173
Mouse	reticulon 3	MGI:1339970	20168
Rat	reticulon 3	RGD:620988	140945
Pig	reticulon 3		100512087

Species	Name	OMA	EggNOG	Inparanoid
Chimp	reticulon 3
Macaque	reticulon 3
Mouse	reticulon 3
Rat	reticulon 3
Pig	reticulon 3

Protein Structure (0 Structures, 1 AlphaFold Model)

Representation

  axes   backbone   ball+stick   cartoon   rocket   rope   spacefill

Color Scheme

  target   atomindex   bfactor   chainname   electrostatic   element   hydrophobicity   resname   sstruc

AF-O95197-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (4)

Reactome (3)

KEGG (1)

Neuronal System (R-HSA-112316)

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Items per page:

5

1 – 3 of 3

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Neuronal System	398 targets	R-HSA-112316
Reactome	Protein-protein interactions at synapses	91 targets	R-HSA-6794362
Reactome	Synaptic adhesion-like molecules	21 targets	R-HSA-8849932

Name	Explore in Pharos	Explore in Source
Neuronal System	398 targets	R-HSA-112316
Protein-protein interactions at synapses	91 targets	R-HSA-6794362
Synaptic adhesion-like molecules	21 targets	R-HSA-8849932

Gene Ontology Terms (12)

Components (7)

Processes (5)

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Items per page:

10

1 – 7 of 7

GO Term	Evidence	Assigned by
endoplasmic reticulum	Inferred from Direct Assay (IDA)	HPA
endoplasmic reticulum membrane	Inferred from Direct Assay (IDA)	UniProtKB
extracellular space	Traceable Author Statement (TAS)	ProtInc
plasma membrane	Traceable Author Statement (TAS)	Reactome
Golgi membrane	Inferred from Electronic Annotation (IEA)	UniProtKB-SubCell
integral component of membrane	Inferred from Electronic Annotation (IEA)	UniProtKB-KW
synapse	Inferred from Electronic Annotation (IEA)	Ensembl

Protein-Protein Interactions (58)

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1 – 10 of 58

• See Interactions on String-DB

FAM241A

Tdark

Novelty: 1.04041354

p_int: 0.95844006

p_ni: 0.04155994

Data Source: BioPlex

RTN4

Tbio

Novelty: 0.00080371

p_int: 0.787187221

p_ni: 0.212812779

Score: 0.905

Data Source: BioPlex,STRINGDB

LRFN2

Tbio

Novelty: 0.07450569

Score: 0.919

Data Source: Reactome,STRINGDB

LRFN1

Tdark

Novelty: 0.21439206

Score: 0.908

Data Source: STRINGDB

LRFN3

Tdark

Novelty: 0.30018245

Score: 0.906

Data Source: Reactome,STRINGDB

LRFN4

Tbio

Novelty: 0.12511571

Score: 0.906

Data Source: STRINGDB

BACE1

Tchem

Family: Enzyme

Novelty: 0.00042175

Score: 0.8

Data Source: STRINGDB

REEP5

Tbio

Novelty: 0.00160455

Score: 0.766

Data Source: STRINGDB

SLC30A3

Tbio

Family: Transporter

Novelty: 0.00683607

Score: 0.732

Data Source: STRINGDB

VTA1

Tbio

Novelty: 0.01697854

Score: 0.731

Data Source: STRINGDB

Publication Statistics

PubMed Score  50.64

PubMed score by year

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PubTator Score  115.75

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

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UniProt Keyword Find Similar Targets

Acetylation
Alternative splicing
Apoptosis
Complete proteome
Endoplasmic reticulum
ER-Golgi transport
Golgi apparatus
Host-virus interaction
Membrane
Phosphoprotein