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Tbio
CSPG5
Chondroitin sulfate proteoglycan 5

Protein Summary
Description
May function as a growth and differentiation factor involved in neuritogenesis. May induce ERBB3 activation. The protein encoded by this gene is a proteoglycan that may function as a neural growth and differentiation factor. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000264723
  • ENSP00000264723
  • ENSG00000114646
  • ENST00000383738
  • ENSP00000373244
  • ENST00000456150
  • ENSP00000392096

Symbol
  • CALEB
  • NGC
  • NGC
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
pathway
0.95
cellular component
0.84
PubMedID
0.75
kinase perturbation
0.71
biological process
0.69


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 70.91   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 228   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 70.91   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 228   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking status measurement
1
1
1
81.2
body mass index
1
1
1
16
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking status measurement
1
81.2
body mass index
1
16
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
chondroitin sulfate proteoglycan 5
VGNC:6187
460336
Macaque
chondroitin sulfate proteoglycan 5
711213
Mouse
MGI:1352747
29873
Rat
RGD:2431
50568
Dog
chondroitin sulfate proteoglycan 5
VGNC:39671
609188
Species
Name
OMA
EggNOG
Inparanoid
Chimp
chondroitin sulfate proteoglycan 5
Macaque
chondroitin sulfate proteoglycan 5
Mouse
Rat
Dog
chondroitin sulfate proteoglycan 5
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-O95196-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (18)
A tetrasaccharide linker sequence is required for GAG synthesis (R-HSA-1971475)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 18
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
A tetrasaccharide linker sequence is required for GAG synthesis
Reactome
CS/DS degradation
Reactome
Chondroitin sulfate biosynthesis
Reactome
Chondroitin sulfate/dermatan sulfate metabolism
Reactome
Defective B3GALT6 causes EDSP2 and SEMDJL1
Name
Explore in Pharos
Explore in Source
A tetrasaccharide linker sequence is required for GAG synthesis
CS/DS degradation
Chondroitin sulfate biosynthesis
Chondroitin sulfate/dermatan sulfate metabolism
Defective B3GALT6 causes EDSP2 and SEMDJL1
Gene Ontology Terms (24)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
UniProtKB
Protein-Protein Interactions (82)
1 – 10 of 82
MLX
Tchem
Family: TF
Novelty: 0.0059946
p_int: 0.999999694
p_ni: 2.53e-7
p_wrong: 5.3e-8
Score: 0.219
Data Source: BioPlex,STRINGDB
DLK1
Tchem
Novelty: 0.00212394
p_int: 0.994162198
p_ni: 0.000031844
p_wrong: 0.005805959
Score: 0.183
Data Source: BioPlex,STRINGDB
COLEC12
Tbio
Novelty: 0.02882427
p_int: 0.990550254
p_ni: 0.000037186
p_wrong: 0.009412559
Score: 0.638
Data Source: BioPlex,STRINGDB
TMX1
Tbio
Novelty: 0.03444237
p_int: 0.979639444
p_ni: 0.000002482
p_wrong: 0.020358074
Score: 0.8
Data Source: BioPlex,STRINGDB
NCAN
Tbio
Novelty: 0.00401824
Score: 0.969
Data Source: STRINGDB
CSPG4
Tbio
Novelty: 0.0038499
Score: 0.967
Data Source: STRINGDB
BCAN
Tbio
Novelty: 0.00737982
Score: 0.963
Data Source: STRINGDB
VCAN
Tbio
Novelty: 0.00110986
Score: 0.931
Data Source: STRINGDB
GPC2
Tbio
Novelty: 0.02182363
Score: 0.93
Data Source: STRINGDB
SDC3
Tbio
Novelty: 0.01095269
Score: 0.929
Data Source: STRINGDB
Publication Statistics
PubMed Score  70.91

PubMed score by year
PubTator Score  7.29

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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