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Tbio
UNC5C
Netrin receptor UNC5C

Protein Classes
Protein Summary
Description
Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. Also involved in corticospinal tract axon guidances independently of DCC. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. This gene product belongs to the UNC-5 family of netrin receptors. Netrins are secreted proteins that direct axon extension and cell migration during neural development. They are bifunctional proteins that act as attractants for some cell types and as repellents for others, and these opposite actions are thought to be mediated by two classes of receptors. The UNC-5 family of receptors mediate the repellent response to netrin; they are transmembrane proteins containing 2 immunoglobulin (Ig)-like domains and 2 type I thrombospondin motifs in the ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000453304
  • ENSP00000406022
  • ENSG00000182168
  • ENST00000506749
  • ENSP00000426153

Symbol
  • UNC5H3
  • UNC5H3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.97
trait
0.97
phenotype
0.74
disease
0.69
disease perturbation
0.68


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 54.22   (req: < 5)
Gene RIFs: 28   (req: <= 3)
Antibodies: 243   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 54.22   (req: >= 5)
Gene RIFs: 28   (req: > 3)
Antibodies: 243   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
1
2
70.9
body mass index
1
1
1
67.4
1
1
0
3
37.5
1
1
1
21.8
body height
1
1
1
14.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
70.9
body mass index
1
67.4
0
3
37.5
1
21.8
body height
1
14.1
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
unc-5 netrin receptor C
VGNC:2063
471254
Macaque
unc-5 netrin receptor C
705591
Mouse
MGI:1095412
22253
Rat
RGD:735109
362049
Dog
unc-5 netrin receptor C
VGNC:48141
478485
Species
Name
OMA
EggNOG
Inparanoid
Chimp
unc-5 netrin receptor C
Macaque
unc-5 netrin receptor C
Mouse
Rat
Dog
unc-5 netrin receptor C
Pathways (7)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Developmental Biology
Reactome
Netrin mediated repulsion signals
Reactome
Netrin-1 signaling
Name
Explore in Pharos
Explore in Source
Axon guidance
Developmental Biology
Netrin mediated repulsion signals
Netrin-1 signaling
Gene Ontology Terms (12)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (50)
1 – 10 of 50
NTN1
Tbio
Novelty: 0.00183678
Score: 0.995
Data Source: Reactome,STRINGDB
DCC
Tbio
Novelty: 0.01273911
Score: 0.978
Data Source: Reactome,STRINGDB
FYN
Tclin
Family: Kinase
Novelty: 0.00072167
Score: 0.925
Data Source: STRINGDB
PTK2
Tclin
Family: Kinase
Novelty: 0.00066622
Score: 0.922
Data Source: STRINGDB
SRC
Tclin
Family: Kinase
Novelty: 0.00008479
Score: 0.922
Data Source: Reactome,STRINGDB
YES1
Tclin
Family: Kinase
Novelty: 0.00534936
Score: 0.908
Data Source: STRINGDB
UNC5D
Tbio
Novelty: 0.06891857
Score: 0.907
Data Source: STRINGDB
UNC5A
Tbio
Novelty: 0.03749855
Score: 0.907
Data Source: STRINGDB
UNC5B
Tbio
Novelty: 0.01474065
Score: 0.905
Data Source: STRINGDB
PTPN11
Tchem
Family: Enzyme
Novelty: 0.00073124
Score: 0.9
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  54.22

PubMed score by year
PubTator Score  28.83

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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