Tclin NDUFA7 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7

Protein Summary

Description

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. This gene encodes a subunit of NADH:ubiquinone oxidoreductase (complex I), which is a multiprotein complex located in the inner mitochondrial membrane. Complex I functions in the transfer of electrons from NADH to the respiratory chain. [provided by RefSeq, Mar 2011]

Uniprot Accession IDs

• O95182

Gene Name

• NDUFA7

Ensembl ID

• ENST00000301457
• ENSP00000301457
• ENSG00000267855
• ENST00000593729
• ENSP00000470962

Symbol

• B14.5a
• CI-B14.5a

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.98
disease perturbation	0.9
histone modification site profile	0.84
kinase perturbation	0.84
transcription factor binding site profile	0.84

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Target Illumination GWAS Analytics (TIGA)

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GENEVA

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GlyGen

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.31   (req: < 5)

Gene RIFs: 1   (req: <= 3)

Antibodies: 231   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.31   (req: >= 5)

Gene RIFs: 1   (req: > 3)

Antibodies: 231   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1

Approved Drugs (1)

Explore Approved Drugs

1 – 1 of 1

metformin

NDUFA7Tclin Enzyme

INHIBITOR :

GWAS Traits (22)

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GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
high density lipoprotein cholesterol measurement	EFO_0004612	13	8	20	4	99.5
triglyceride measurement	EFO_0004530	9	3	12		98
apolipoprotein A 1 measurement	EFO_0004614	2	3	4		97.1
very long-chain saturated fatty acid measurement	EFO_0006796	3	2	0	10	91.9
red blood cell distribution width	EFO_0005192	2	2	3		90.7

• Explore on Target Illumination GWAS Analytics (TIGA)

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GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
high density lipoprotein cholesterol measurement	EFO_0004612	20	4	99.5
triglyceride measurement	EFO_0004530	12		98
apolipoprotein A 1 measurement	EFO_0004614	4		97.1
very long-chain saturated fatty acid measurement	EFO_0006796	0	10	91.9
red blood cell distribution width	EFO_0005192	3		90.7

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Orthologs (1)

1 – 1 of 1

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	NADH:ubiquinone oxidoreductase subunit A7		743262

Species	Name	OMA	EggNOG	Inparanoid
Chimp	NADH:ubiquinone oxidoreductase subunit A7

Protein Structure (4 Structures, 1 AlphaFold Model)

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Representation

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Color Scheme

  target   atomindex   bfactor   chainname   electrostatic   element   hydrophobicity   resname   sstruc

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O95182-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 4 of 4

PDB Structure Id	Ligand	Method	Resolution (Å)	Residues	Fraction of Total Protein	Pub Year	Title

PDB Structure Id	Fraction of Total Protein	Resolution	Pub Year

Pathways (17)

Reactome (5)

KEGG (8)

WikiPathways (4)

Complex I biogenesis (R-HSA-6799198)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Complex I biogenesis	55 targets	R-HSA-6799198
Reactome	Metabolism	2112 targets	R-HSA-1430728
Reactome	Respiratory electron transport	101 targets	R-HSA-611105
Reactome	Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.	123 targets	R-HSA-163200
Reactome	The citric acid (TCA) cycle and respiratory electron transport	174 targets	R-HSA-1428517

Name	Explore in Pharos	Explore in Source
Complex I biogenesis	55 targets	R-HSA-6799198
Metabolism	2112 targets	R-HSA-1430728
Respiratory electron transport	101 targets	R-HSA-611105
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.	123 targets	R-HSA-163200
The citric acid (TCA) cycle and respiratory electron transport	174 targets	R-HSA-1428517

Gene Ontology Terms (9)

Functions (2)

Components (4)

Processes (3)

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1 – 2 of 2

GO Term	Evidence	Assigned by
structural constituent of ribosome	Inferred from Sequence or structural Similarity (ISS)	UniProtKB
NADH dehydrogenase (ubiquinone) activity	Non-traceable Author Statement (NAS)	UniProtKB

Protein-Protein Interactions (162)

Explore Interacting Targets

1 – 10 of 162

• See Interactions on String-DB

NDUFB7

Tclin

Family:  Enzyme

Novelty:  0.14580093

p_int:  0.999999735

p_ni:  2.65e-7

Score:  0.999

Data Source:  BioPlex,STRINGDB

NDUFB6

Tclin

Family:  Enzyme

Novelty:  0.075245

p_int:  0.999998725

p_ni:  0.000001275

Score:  0.999

Data Source:  BioPlex,STRINGDB

NDUFB11

Tclin

Family:  Enzyme

Novelty:  0.0401232

p_int:  0.999998576

p_ni:  0.000001424

Score:  0.999

Data Source:  BioPlex,STRINGDB

NDUFS4

Tclin

Family:  Enzyme

Novelty:  0.00787292

p_int:  0.999998116

p_ni:  0.000001884

Score:  0.999

Data Source:  BioPlex,STRINGDB

NDUFB8

Tclin

Family:  Enzyme

Novelty:  0.019021

p_int:  0.999997316

p_ni:  0.000002684

Score:  0.999

Data Source:  BioPlex,STRINGDB

NDUFB9

Tclin

Family:  Enzyme

Novelty:  0.00715628

p_int:  0.99999167

p_ni:  0.00000833

Score:  0.999

Data Source:  BioPlex,STRINGDB

NDUFB5

Tclin

Family:  Enzyme

Novelty:  0.0257403

p_int:  0.999960137

p_ni:  0.000039863

Score:  0.998

Data Source:  BioPlex,STRINGDB

NDUFC2

Tclin

Family:  Enzyme

Novelty:  0.08387385

p_int:  0.999948784

p_ni:  0.000051216

Score:  0.998

Data Source:  BioPlex,STRINGDB

NDUFV3

Tclin

Family:  Enzyme

Novelty:  0.15352039

p_int:  0.999907408

p_ni:  0.000092592

Score:  0.993

Data Source:  BioPlex,STRINGDB

NDUFAF2

Tclin

Novelty:  0.04815608

p_int:  0.999891702

p_ni:  0.000068838

p_wrong:  0.000039459

Score:  0.905

Data Source:  BioPlex,STRINGDB

Publication Statistics

PubMed Score  7.31

PubMed score by year

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PubTator Score  1.45

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

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UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Acetylation
Complete proteome
Electron transport
Membrane
Mitochondrion
Mitochondrion inner membrane
Phosphoprotein
Polymorphism
Reference proteome

GWAS Trait Find Similar Targets

No Header	No Header
apolipoprotein A 1 measurement
blood metabolite measurement
BMI-adjusted waist-hip ratio
coronary artery disease
diastolic blood pressure
high density lipoprotein cholesterol measurement
lipoprotein measurement
mean corpuscular hemoglobin concentration
mean corpuscular volume
mean reticulocyte volume