NDUFA7
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7
Protein Summary
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. This gene encodes a subunit of NADH:ubiquinone oxidoreductase (complex I), which is a multiprotein complex located in the inner mitochondrial membrane. Complex I functions in the transfer of electrons from NADH to the respiratory chain. [provided by RefSeq, Mar 2011]
- ENST00000301457
- ENSP00000301457
- ENSG00000267855
- ENST00000593729
- ENSP00000470962
- B14.5a
- CI-B14.5a
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
virus perturbation | 0.98 | ||
disease perturbation | 0.9 | ||
histone modification site profile | 0.84 | ||
kinase perturbation | 0.84 | ||
transcription factor binding site profile | 0.84 | ||
Related Tools
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 6.15 (req: < 5)
Gene RIFs: 1 (req: <= 3)
Antibodies: 231 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 6.15 (req: >= 5)
Gene RIFs: 1 (req: > 3)
Antibodies: 231 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 5
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
Orthologs (1)
1 – 1 of 1
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | NADH:ubiquinone oxidoreductase subunit A7 | 743262 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | NADH:ubiquinone oxidoreductase subunit A7 | |||||
Protein Structure (4 Structures, 1 AlphaFold Model)
Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB
1 – 4 of 4
PDB Structure Id | Ligand | Method | Resolution (Å) | Residues | Fraction of Total Protein | Pub Year | Title |
|---|
PDB Structure Id | Fraction of Total Protein | Resolution | Pub Year |
|---|
Pathways (17)
Reactome (5)
KEGG (8)
WikiPathways (4)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 5
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Complex I biogenesis | ||||
Reactome | Metabolism | ||||
Reactome | Respiratory electron transport | ||||
Reactome | Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. | ||||
Reactome | The citric acid (TCA) cycle and respiratory electron transport | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Complex I biogenesis | ||||
Metabolism | ||||
Respiratory electron transport | ||||
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. | ||||
The citric acid (TCA) cycle and respiratory electron transport | ||||
Gene Ontology Terms (9)
Functions (2)
Components (4)
Processes (3)
Items per page:
10
1 – 2 of 2
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Non-traceable Author Statement (NAS) | UniProtKB | |||
Protein-Protein Interactions (162)
1 – 10 of 162
NDUFB7
Family: Enzyme
Novelty: 0.14580093
p_int: 0.999999735
p_ni: 2.65e-7
Score: 0.999
Data Source: BioPlex,STRINGDB
NDUFB6
Family: Enzyme
Novelty: 0.075245
p_int: 0.999998725
p_ni: 0.000001275
Score: 0.999
Data Source: BioPlex,STRINGDB
NDUFB11
Family: Enzyme
Novelty: 0.0401232
p_int: 0.999998576
p_ni: 0.000001424
Score: 0.999
Data Source: BioPlex,STRINGDB
NDUFS4
Family: Enzyme
Novelty: 0.00787292
p_int: 0.999998116
p_ni: 0.000001884
Score: 0.999
Data Source: BioPlex,STRINGDB
NDUFB8
Family: Enzyme
Novelty: 0.019021
p_int: 0.999997316
p_ni: 0.000002684
Score: 0.999
Data Source: BioPlex,STRINGDB
NDUFB9
Family: Enzyme
Novelty: 0.00715628
p_int: 0.99999167
p_ni: 0.00000833
Score: 0.999
Data Source: BioPlex,STRINGDB
NDUFB5
Family: Enzyme
Novelty: 0.0257403
p_int: 0.999960137
p_ni: 0.000039863
Score: 0.998
Data Source: BioPlex,STRINGDB
NDUFC2
Family: Enzyme
Novelty: 0.08387385
p_int: 0.999948784
p_ni: 0.000051216
Score: 0.998
Data Source: BioPlex,STRINGDB
NDUFV3
Family: Enzyme
Novelty: 0.15352039
p_int: 0.999907408
p_ni: 0.000092592
Score: 0.993
Data Source: BioPlex,STRINGDB
NDUFAF2
Novelty: 0.04815608
p_int: 0.999891702
p_ni: 0.000068838
p_wrong: 0.000039459
Score: 0.905
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score 6.15
PubMed score by year
PubTator Score 1.45
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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