Tclin CACNA1H Voltage-dependent T-type calcium channel subunit alpha-1H

Protein Summary

Description

Voltage-sensitive calcium channel that gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group. A particularity of this type of channel is an opening at quite negative potentials, and a voltage-dependent inactivation (PubMed:9670923, PubMed:9930755, PubMed:27149520). T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle (Probable). They may also be involved in the modulation of firing patterns of neurons (PubMed:15048902). In the adrenal zona glomerulosa, participates in the signaling pathway leading to aldosterone production in response to either AGT/angiotensin II, or hyperkalemia (PubMed:25907736, PubMed:27729216). This gene encodes a T-type member of the alpha-1 subunit family, a protein in the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. The alpha-1 subunit has 24 transmembrane segments and forms the pore through which ions pass into the cell. There are multiple isoforms of each of the proteins in the complex, either encoded by different genes or the result of alternative splicing of transcripts. Alternate transcriptional splice variants, encoding different isoforms, have been characterized for the gene described here. Studies suggest certain mutations in this gene lead to childhood absence epilepsy (CAE). [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• O95180
• B5ME00
• F8WFD1
• O95802
• Q8WWI6
• Q96QI6
• Q96RZ9
• Q9NYY4
• Q9NYY5

Gene Name

• CACNA1H

Ensembl ID

• ENST00000348261
• ENSP00000334198
• ENSG00000196557
• ENST00000358590
• ENSP00000351401
• ENST00000565831
• ENSP00000455840

Symbol

• ECA6
• EIG6
• HALD4
• Cav3.2
• CACNA1HB

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.91
biological process	0.85
small molecule perturbation	0.68
PubMedID	0.67
transcription factor	0.64

Protein Classes

PANTHER Classes

Protein / Transporter / Ion Channel / Voltage-gated Ion Channel / Voltage-gated Sodium Channel / Voltage-dependent T-type Calcium Channel Subunit Alpha-1h

Protein / Transporter / Ion Channel / Voltage-gated Ion Channel / Voltage-gated Calcium Channel / Voltage-dependent T-type Calcium Channel Subunit Alpha-1h

Protein / Transporter / Ion Channel / Sodium Channel / Voltage-gated Sodium Channel / Voltage-dependent T-type Calcium Channel Subunit Alpha-1h

Protein / Transporter / Ion Channel / Calcium Channel / Voltage-gated Calcium Channel / Voltage-dependent T-type Calcium Channel Subunit Alpha-1h

DTO Classes

Protein / Ion Channel / Calcium Channel Alpha-1 Subunit Family / Cacna1h Subfamily / Voltage-dependent T-type Calcium Channel Subunit Alpha-1h

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 391.4   (req: < 5)

Gene RIFs: 90   (req: <= 3)

Antibodies: 268   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 391.4   (req: >= 5)

Gene RIFs: 90   (req: > 3)

Antibodies: 268   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 390

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 7