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Tclin
CACNA1H
Voltage-dependent T-type calcium channel subunit alpha-1H

Protein Classes
Protein Summary
Description
Voltage-sensitive calcium channel that gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group. A particularity of this type of channel is an opening at quite negative potentials, and a voltage-dependent inactivation (PubMed:9670923, PubMed:9930755, PubMed:27149520). T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle (Probable). They may also be involved in the modulation of firing patterns of neurons (PubMed:15048902). In the adrenal zona glomerulosa, participates in the signaling pathway leading to aldosterone production in response to either AGT/angiotensin II, or hyperkalemia (PubMed:25907736, PubMed:27729216). This gene encodes a T-type member of the alpha-1 subunit family, a protein in the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000348261
  • ENSP00000334198
  • ENSG00000196557
  • ENST00000358590
  • ENSP00000351401
  • ENST00000565831
  • ENSP00000455840

Symbol
  • ECA6
  • EIG6
  • HALD4
  • Cav3.2
  • CACNA1HB
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.91
biological process
0.85
small molecule perturbation
0.68
PubMedID
0.67
transcription factor
0.64


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 192.67   (req: < 5)
Gene RIFs: 71   (req: <= 3)
Antibodies: 268   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 192.67   (req: >= 5)
Gene RIFs: 71   (req: > 3)
Antibodies: 268   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 213
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 7
Pathways (13)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Developmental Biology
Reactome
NCAM signaling for neurite out-growth
Reactome
NCAM1 interactions
Name
Explore in Pharos
Explore in Source
Axon guidance
Developmental Biology
NCAM signaling for neurite out-growth
NCAM1 interactions
Protein-Protein Interactions (118)
1 – 10 of 118
NCAM1
Tbio
Novelty: 0.00028477
Score: 0.904
Data Source: Reactome,STRINGDB
CACNB4
Tbio
Family: IC
Novelty: 0.02329242
Score: 0.895
Data Source: STRINGDB
CACNG1
Tbio
Family: IC
Novelty: 0.174255
Score: 0.887
Data Source: STRINGDB
CACNA2D1
Tclin
Family: IC
Novelty: 0.0266267
Score: 0.885
Data Source: STRINGDB
CACNB3
Tbio
Family: IC
Novelty: 0.06538322
Score: 0.877
Data Source: STRINGDB
CACNB2
Tbio
Family: IC
Novelty: 0.02869423
Score: 0.867
Data Source: STRINGDB
CACNA2D4
Tbio
Family: IC
Novelty: 0.0338901
Score: 0.861
Data Source: STRINGDB
CAV3
Tbio
Novelty: 0.00250765
Score: 0.842
Data Source: STRINGDB
GNG2
Tbio
Novelty: 0.08273543
Score: 0.836
Data Source: STRINGDB
CATSPERG
Tdark
Novelty: 4
Score: 0.833
Data Source: STRINGDB
Publication Statistics
PubMed Score  192.67

PubMed score by year
PubTator Score  131.44

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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