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Tclin
CACNA1H
Voltage-dependent T-type calcium channel subunit alpha-1H

Protein Summary
Description
Voltage-sensitive calcium channel that gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group. A particularity of this type of channel is an opening at quite negative potentials, and a voltage-dependent inactivation (PubMed:9670923, PubMed:9930755, PubMed:27149520). T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle (Probable). They may also be involved in the modulation of firing patterns of neurons (PubMed:15048902). In the adrenal zona glomerulosa, participates in the signaling pathway leading to aldosterone production in response to either AGT/angiotensin II, or hyperkalemia (PubMed:25907736, PubMed:27729216). This gene encodes a T-type member of the alpha-1 subunit family, a protein in the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000348261
  • ENSP00000334198
  • ENSG00000196557
  • ENST00000358590
  • ENSP00000351401
  • ENST00000565831
  • ENSP00000455840

Symbol
  • ECA6
  • EIG6
  • HALD4
  • Cav3.2
  • CACNA1HB
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.91
biological process
0.85
small molecule perturbation
0.68
PubMedID
0.67
transcription factor
0.64


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 341.74   (req: < 5)
Gene RIFs: 71   (req: <= 3)
Antibodies: 268   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 341.74   (req: >= 5)
Gene RIFs: 71   (req: > 3)
Antibodies: 268   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 390
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 7
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (118)
NCAM1
Tbio
Novelty:  0.00020994
Score:  0.904
Data Source:  Reactome,STRINGDB
CACNB4
Tbio
Family:  IC
Novelty:  0.01564026
Score:  0.895
Data Source:  STRINGDB
CACNG1
Tbio
Family:  IC
Novelty:  0.11899252
Score:  0.887
Data Source:  STRINGDB
CACNA2D1
Tclin
Family:  IC
Novelty:  0.01744541
Score:  0.885
Data Source:  STRINGDB
CACNB3
Tbio
Family:  IC
Novelty:  0.04007679
Score:  0.877
Data Source:  STRINGDB
CACNB2
Tbio
Family:  IC
Novelty:  0.01745218
Score:  0.867
Data Source:  STRINGDB
CACNA2D4
Tbio
Family:  IC
Novelty:  0.02238343
Score:  0.861
Data Source:  STRINGDB
CAV3
Tbio
Novelty:  0.00190092
Score:  0.842
Data Source:  STRINGDB
GNG2
Tbio
Novelty:  0.04807242
Score:  0.836
Data Source:  STRINGDB
CATSPERG
Tdark
Novelty:  0.73161601
Score:  0.833
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (13)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Developmental Biology
Reactome
NCAM signaling for neurite out-growth
Reactome
NCAM1 interactions
Name
Explore in Pharos
Explore in Source
Axon guidance
Developmental Biology
NCAM signaling for neurite out-growth
NCAM1 interactions
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (16)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
IGF-1 measurement
1
4
4
97.6
mathematical ability
4
4
4
90.4
self reported educational attainment
1
1
1
73.3
heel bone mineral density
2
2
2
72
neutrophil count
2
2
2
71.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
IGF-1 measurement
4
97.6
mathematical ability
4
90.4
self reported educational attainment
1
73.3
heel bone mineral density
2
72
neutrophil count
2
71.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
calcium voltage-gated channel subunit alpha1 H
VGNC:51205
453813
Mouse
MGI:1928842
58226
Rat
RGD:68943
114862
Dog
calcium voltage-gated channel subunit alpha1 H
VGNC:38638
403533
Horse
calcium voltage-gated channel subunit alpha1 H
VGNC:51118
100067492
Species
Name
OMA
EggNOG
Inparanoid
Chimp
calcium voltage-gated channel subunit alpha1 H
Mouse
Rat
Dog
calcium voltage-gated channel subunit alpha1 H
Horse
calcium voltage-gated channel subunit alpha1 H
Publication Statistics
PubMed Score 341.74
PubMed score by year
PubTator Score 131.44
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title