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Tclin
NDUFB2
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial

Protein Summary
Description
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. The protein encoded by this gene is a subunit of the multisubunit NADH:ubiquinone oxidoreductase (complex I). Mammalian complex I is composed of 45 different subunits. This protein has NADH dehydrogenase activity and oxidoreductase activity. It plays a important role in transfering electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Hydropathy analysis revealed that this subunit and 4 other subunits have an overall hydrophilic pattern, even though they are found within the hydrophobic protein (HP) fraction of complex I. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000247866
  • ENSP00000247866
  • ENSG00000090266
  • ENST00000465506
  • ENSP00000419357
  • ENST00000476279
  • ENSP00000419087

Symbol
  • AGGG
  • CI-AGGG
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
1
disease perturbation
0.99
transcription factor perturbation
0.97
virus perturbation
0.85
cellular component
0.81


Related Tools
GENEVA
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GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.46   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 43   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.46   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 43   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
metformin
chemical structure image
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
NADH:ubiquinone oxidoreductase subunit B2
VGNC:4441
463780
Macaque
NADH:ubiquinone oxidoreductase subunit B2
693431
Mouse
MGI:1915448
68198
Rat
RGD:1308130
362344
Dog
NADH:ubiquinone oxidoreductase subunit B2
VGNC:43701
100683846
Species
Name
OMA
EggNOG
Inparanoid
Chimp
NADH:ubiquinone oxidoreductase subunit B2
Macaque
NADH:ubiquinone oxidoreductase subunit B2
Mouse
Rat
Dog
NADH:ubiquinone oxidoreductase subunit B2
Protein Structure (4 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O95178-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (17)
Complex I biogenesis (R-HSA-6799198)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Complex I biogenesis
Reactome
Metabolism
Reactome
Respiratory electron transport
Reactome
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
Reactome
The citric acid (TCA) cycle and respiratory electron transport
Name
Explore in Pharos
Explore in Source
Complex I biogenesis
Metabolism
Respiratory electron transport
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
The citric acid (TCA) cycle and respiratory electron transport
Gene Ontology Terms (5)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Non-traceable Author Statement (NAS)
UniProtKB
Protein-Protein Interactions (166)
1 – 10 of 166
NDUFA7
Tclin
Family: Enzyme
Novelty: 0.16417588
p_int: 0.998088582
p_ni: 0.000001056
p_wrong: 0.001910362
Score: 0.998
Data Source: BioPlex,STRINGDB
NDUFV3
Tclin
Family: Enzyme
Novelty: 0.15352039
p_int: 0.964484786
p_ni: 1.99e-7
p_wrong: 0.035515015
Score: 0.991
Data Source: BioPlex,STRINGDB
NDUFB10
Tclin
Family: Enzyme
Novelty: 0.05791757
Score: 0.999
Data Source: STRINGDB
NDUFA6
Tclin
Family: Enzyme
Novelty: 0.01236094
Score: 0.999
Data Source: STRINGDB
NDUFS5
Tclin
Family: Enzyme
Novelty: 0.13274675
Score: 0.999
Data Source: STRINGDB
NDUFC1
Tclin
Family: Enzyme
Novelty: 0.48303612
Score: 0.999
Data Source: STRINGDB
NDUFB5
Tclin
Family: Enzyme
Novelty: 0.0257403
Score: 0.999
Data Source: STRINGDB
NDUFA2
Tclin
Family: Enzyme
Novelty: 0.02698508
Score: 0.999
Data Source: STRINGDB
NDUFB6
Tclin
Family: Enzyme
Novelty: 0.075245
Score: 0.999
Data Source: STRINGDB
NDUFB4
Tclin
Family: Enzyme
Novelty: 0.02123344
Score: 0.999
Data Source: STRINGDB
Publication Statistics
PubMed Score  16.46

PubMed score by year
PubTator Score  37.77

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer