NDUFB2
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial
Protein Summary
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. The protein encoded by this gene is a subunit of the multisubunit NADH:ubiquinone oxidoreductase (complex I). Mammalian complex I is composed of 45 different subunits. This protein has NADH dehydrogenase activity and oxidoreductase activity. It plays a important role in transfering electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Hydropathy analysis revealed that this subunit and 4 other subunits have an overall hydrophilic pattern, even though they are found within the hydrophobic protein (HP) fraction of complex I. [provided by RefSeq, Jul 2008]
- ENST00000247866
- ENSP00000247866
- ENSG00000090266
- ENST00000465506
- ENSP00000419357
- ENST00000476279
- ENSP00000419087
- AGGG
- CI-AGGG
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
kinase perturbation | 1 | ||
disease perturbation | 0.99 | ||
transcription factor perturbation | 0.97 | ||
virus perturbation | 0.85 | ||
cellular component | 0.81 | ||
Related Tools
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ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 16.46 (req: < 5)
Gene RIFs: 2 (req: <= 3)
Antibodies: 43 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 16.46 (req: >= 5)
Gene RIFs: 2 (req: > 3)
Antibodies: 43 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 3
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | NADH:ubiquinone oxidoreductase subunit B2 | VGNC:4441 | 463780 | |||||
Macaque | NADH:ubiquinone oxidoreductase subunit B2 | 693431 | ||||||
Mouse | MGI:1915448 | 68198 | ||||||
Rat | RGD:1308130 | 362344 | ||||||
Dog | NADH:ubiquinone oxidoreductase subunit B2 | VGNC:43701 | 100683846 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | NADH:ubiquinone oxidoreductase subunit B2 | |||||
Macaque | NADH:ubiquinone oxidoreductase subunit B2 | |||||
Mouse | ||||||
Rat | ||||||
Dog | NADH:ubiquinone oxidoreductase subunit B2 | |||||
Protein Structure (4 Structures, 1 AlphaFold Model)
Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB
1 – 4 of 4
PDB Structure Id | Ligand | Method | Resolution (Å) | Residues | Fraction of Total Protein | Pub Year | Title |
|---|
PDB Structure Id | Fraction of Total Protein | Resolution | Pub Year |
|---|
Pathways (17)
Reactome (5)
KEGG (8)
WikiPathways (4)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 5
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Complex I biogenesis | ||||
Reactome | Metabolism | ||||
Reactome | Respiratory electron transport | ||||
Reactome | Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. | ||||
Reactome | The citric acid (TCA) cycle and respiratory electron transport | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Complex I biogenesis | ||||
Metabolism | ||||
Respiratory electron transport | ||||
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. | ||||
The citric acid (TCA) cycle and respiratory electron transport | ||||
Gene Ontology Terms (5)
Functions (1)
Components (2)
Processes (2)
Items per page:
10
1 – 1 of 1
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Non-traceable Author Statement (NAS) | UniProtKB | |||
Protein-Protein Interactions (166)
1 – 10 of 166
NDUFA7
Family: Enzyme
Novelty: 0.16417588
p_int: 0.998088582
p_ni: 0.000001056
p_wrong: 0.001910362
Score: 0.998
Data Source: BioPlex,STRINGDB
NDUFV3
Family: Enzyme
Novelty: 0.15352039
p_int: 0.964484786
p_ni: 1.99e-7
p_wrong: 0.035515015
Score: 0.991
Data Source: BioPlex,STRINGDB
NDUFB10
Family: Enzyme
Novelty: 0.05791757
Score: 0.999
Data Source: STRINGDB
NDUFA6
Family: Enzyme
Novelty: 0.01236094
Score: 0.999
Data Source: STRINGDB
NDUFS5
Family: Enzyme
Novelty: 0.13274675
Score: 0.999
Data Source: STRINGDB
NDUFC1
Family: Enzyme
Novelty: 0.48303612
Score: 0.999
Data Source: STRINGDB
NDUFB5
Family: Enzyme
Novelty: 0.0257403
Score: 0.999
Data Source: STRINGDB
NDUFA2
Family: Enzyme
Novelty: 0.02698508
Score: 0.999
Data Source: STRINGDB
NDUFB6
Family: Enzyme
Novelty: 0.075245
Score: 0.999
Data Source: STRINGDB
NDUFB4
Family: Enzyme
Novelty: 0.02123344
Score: 0.999
Data Source: STRINGDB
Publication Statistics
PubMed Score 16.46
PubMed score by year
PubTator Score 37.77
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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