Tdark CDRT1 CMT1A duplicated region transcript 1 protein

Protein Summary

Description

Members of the F-box protein family, such as FBXW10, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603034), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]

Uniprot Accession IDs

• O95170
• O43848
• O95611

Gene Name

• CDRT1

Ensembl ID

• ENST00000354433
• ENSP00000346416
• ENSG00000241322
• ENST00000395906
• ENSP00000379242

Symbol

• C17orf1
• C17orf1A
• HREP
• HREP
• SM25H2
• C170RF1
• C17ORF1
• FBXW10B
• C17ORF1A
• FBXW10P1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.85
ligand (protein) perturbation	0.83
tissue sample	0.57
small molecule perturbation	0.56
cell type or tissue	0.55

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.9   (req: < 5)

Gene RIFs: 0   (req: <= 3)

Antibodies: 3   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.9   (req: >= 5)

Gene RIFs: 0   (req: > 3)

Antibodies: 3   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0